Last updated July 18, 2026
Key finding
FPG decreased compared to placebo (-0.24±0.50 vs +0.12±0.59 mmol/L, respectively, p = 0.02)
This study examined the effects of a dietary supplement containing cinnamon, chromium, and carnosine on fasting plasma glucose in prediabetic individuals, finding a significant reduction in fasting plasma glucose levels compared to placebo.
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study examined the effects of a dietary supplement containing cinnamon, chromium, and carnosine on fasting plasma glucose in prediabetic individuals, finding a significant reduction in fasting plasma glucose levels compared to placebo.
These findings are clinically significant as they suggest that dietary supplementation may be a viable strategy for managing fasting plasma glucose levels in prediabetic individuals, potentially reducing the risk of progression to type 2 diabetes. Understanding the impact of such supplements can help healthcare providers offer more comprehensive dietary recommendations to patients at risk.
The study did not report on long-term effects of the dietary supplement. Sample size and demographic characteristics may limit generalizability. No significant changes in HbA1c raise questions about clinical relevance.
Published in
Publication details and source links for this paper.
Yuejun L, Aurélie C, Camille V, et al. Effects of a Dietary Supplement Containing Cinnamon, Chromium, and Carnosine on Fasting Plasma Glucose in Prediabetic Subjects. PLOS ONE. 2015;10(9):e0138646. doi:10.1371/journal.pone.0138646
Fasting plasma glucose decreased by -0.24 mmol/L in the supplement group compared to placebo (p = 0.02).
Fat-free mass (%) increased with the dietary supplement compared to placebo (p = 0.02).
No significant changes were observed in HbA1c levels.
Evidence network
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This study contributes evidence to Dietary supplement containing cinnamon, chromium and carnosine and Fasting Plasma Glucose (FPG), HbA1c, Lean body mass.
This study contributes evidence to
Primary intervention
Dietary supplement containing cinnamon, chromium and carnosine
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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Evidence pairs
732
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
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Core evidence
The primary outcomes reported in this study.
Dietary supplement containing cinnamon, chromium and carnosine → Fasting Plasma Glucose (FPG)
Dietary supplement containing cinnamon, chromium and carnosine → Fasting Plasma Glucose (FPG)
Dietary supplement containing cinnamon, chromium and carnosine → HbA1c
Dietary supplement containing cinnamon, chromium and carnosine → HbA1c
Dietary supplement containing cinnamon, chromium and carnosine → Lean body mass
Dietary supplement containing cinnamon, chromium and carnosine → Lean body mass
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Dietary supplement containing cinnamon, chromium and carnosine and Fasting Glucose, Dietary supplement containing cinnamon, chromium and carnosine and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies on Dietary supplement containing cinnamon, chromium and carnosine
Contributes to Dietary supplement containing cinnamon, chromium and carnosine evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Dietary supplement containing cinnamon, chromium and carnosine appears to improve Fasting Plasma Glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Dietary supplement containing cinnamon, chromium and carnosine appears to improve Lean body mass.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Lean body mass
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Dietary supplement containing cinnamon, chromium and carnosine for HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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