NoneNo Change
2-hour plasma glucose
Curcumin plus fish oil → 2-hour plasma glucose
Curcumin plus fish oil → 2-hour plasma glucose
Evidence profile
NoneNo ChangeGlycemic Control
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Research Summary
Analyzed using Evidence Intelligence™
Dietary supplements may lower diabetes risk in prediabetes
Key finding
The intervention groups significantly lowered the progression of type 2 diabetes among prediabetes individuals.
This study investigated the effects of dietary supplements on the risk of developing diabetes in individuals with prediabetes, finding that certain interventions reduced progression to overt diabetes.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Some Concerns bias
Last updated July 2, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Placebo, Curcumin plus fish oil and vitamin D, Curcumin plus fish oil
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Progression to overt diabetes
Evidence
Moderate confidence
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the effects of dietary supplements on the risk of developing diabetes in individuals with prediabetes, finding that certain interventions reduced progression to overt diabetes.
Clinical relevance
These findings are significant as they suggest that dietary interventions can play a role in diabetes prevention. With the increasing prevalence of prediabetes, identifying effective strategies to halt its progression is crucial for public health. This study highlights the potential of specific dietary supplements in managing diabetes risk, which could inform clinical practices and dietary recommendations.
Keep in mind
The study did not demonstrate significant effects on various metabolic parameters. The sample size and demographic characteristics may limit generalizability. The long-term effects of the interventions were not assessed.
Published in
Journal Reference
Publication details and source links for this paper.
Preeyapat C, Tiersidh N, Korbtham S, Sathit N. The Effect of Dietary Supplements on Diabetic Risk in Prediabetes: A Randomized Controlled Trial. Journal of the Endocrine Society. 2022;6(Suppl 1):A269-A269. doi:10.1210/jendso/bvac150.554
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Main Effects
The intervention groups significantly lowered the progression to overt diabetes among prediabetes individuals.
No significant effects were found on fasting plasma glucose levels.
No significant effects were observed on body weight changes.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Curcumin plus fish oil, Curcumin plus fish oil and vitamin D and 2-hour plasma glucose, BMI, Body weight, and 4 more.
This study contributes evidence to
Primary intervention
Curcumin plus fish oil
Primary outcomes
- 2-hour plasma glucose
- BMI
- Body weight
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
14
Evidence pairs
14
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
14
Evidence pairs
358
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 14 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
NoneNo Change
BMI
Curcumin plus fish oil → BMI
Curcumin plus fish oil → BMI
Evidence profile
NoneNo ChangeWeight & Anthropometrics
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NoneNo Change
Body weight
Curcumin plus fish oil → Body weight
Curcumin plus fish oil → Body weight
Evidence profile
NoneNo ChangeWeight & Anthropometrics
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NoneNo Change
Fasting Plasma Glucose (FPG)
Curcumin plus fish oil → Fasting Plasma Glucose (FPG)
Curcumin plus fish oil → Fasting Plasma Glucose (FPG)
Evidence profile
NoneNo ChangeGlycemic Control
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NoneNo Change
HbA1c
Curcumin plus fish oil → HbA1c
Curcumin plus fish oil → HbA1c
Evidence profile
NoneNo ChangeGlycemic Control
Unlock full evidence details
NoneNo Change
lipid profiles
Curcumin plus fish oil → lipid profiles
Curcumin plus fish oil → lipid profiles
Evidence profile
NoneNo ChangeMetabolic Health
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StrongDecrease
Progression to overt diabetes
Curcumin plus fish oil → Progression to overt diabetes
Curcumin plus fish oil → Progression to overt diabetes
Evidence profile
StrongDecreaseClinical Outcomes
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NoneNo Change
2-hour plasma glucose
Curcumin plus fish oil and vitamin D → 2-hour plasma glucose
Curcumin plus fish oil and vitamin D → 2-hour plasma glucose
Evidence profile
NoneNo ChangeGlycemic Control
Unlock full evidence details
NoneNo Change
BMI
Curcumin plus fish oil and vitamin D → BMI
Curcumin plus fish oil and vitamin D → BMI
Evidence profile
NoneNo ChangeWeight & Anthropometrics
Unlock full evidence details
NoneNo Change
Body weight
Curcumin plus fish oil and vitamin D → Body weight
Curcumin plus fish oil and vitamin D → Body weight
Evidence profile
NoneNo ChangeWeight & Anthropometrics
Unlock full evidence details
NoneNo Change
Fasting Plasma Glucose (FPG)
Curcumin plus fish oil and vitamin D → Fasting Plasma Glucose (FPG)
Curcumin plus fish oil and vitamin D → Fasting Plasma Glucose (FPG)
Evidence profile
NoneNo ChangeGlycemic Control
Unlock full evidence details
NoneNo Change
HbA1c
Curcumin plus fish oil and vitamin D → HbA1c
Curcumin plus fish oil and vitamin D → HbA1c
Evidence profile
NoneNo ChangeGlycemic Control
Unlock full evidence details
NoneNo Change
lipid profiles
Curcumin plus fish oil and vitamin D → lipid profiles
Curcumin plus fish oil and vitamin D → lipid profiles
Evidence profile
NoneNo ChangeMetabolic Health
Unlock full evidence details
StrongDecrease
Progression to overt diabetes
Curcumin plus fish oil and vitamin D → Progression to overt diabetes
Curcumin plus fish oil and vitamin D → Progression to overt diabetes
Evidence profile
StrongDecreaseClinical Outcomes
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Evidence Suggest
- Interventions significantly reduced the progression to diabetes by -0.77 events (p=0.046).
- No significant changes in fasting plasma glucose or body weight were observed.
- Similar results were noted across multiple metabolic outcomes.
Who this applies to
- Adults diagnosed with prediabetes.
- Individuals at risk of developing type 2 diabetes.
Keep in Mind
- Results may not apply to populations outside the study sample.
- The study focused on short-term outcomes; long-term effects remain unclear.
- Further research is needed to confirm these findings and explore additional interventions.
Between the Lines
- The study did not demonstrate significant effects on various metabolic parameters.
- The sample size and demographic characteristics may limit generalizability.
- The long-term effects of the interventions were not assessed.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Diabetes Incidence and Prevention, Curcumin Supplements and Diabetes Incidence and Prevention.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Curcumin Supplements Evidence Hub
All studies on Curcumin Supplements
1 studies
intervention_hubContributes to Curcumin Supplements evidence base.
Diabetes Incidence and Prevention Evidence Hub
All studies measuring Diabetes Incidence and Prevention
1 studies
outcome_hubMeasures Diabetes Incidence and Prevention as a key outcome.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Curcumin plus fish oil and Progression to overt diabetes
Intervention: Curcumin plus fish oilOutcome: Progression to overt diabetes
1 results
All studies on Curcumin plus fish oil and vitamin D and Progression to overt diabetes
Intervention: Curcumin plus fish oil and vitamin DOutcome: Progression to overt diabetes
1 results
All studies on Curcumin plus fish oil
Intervention: Curcumin plus fish oil
1 results
All studies on Curcumin plus fish oil and vitamin D
Intervention: Curcumin plus fish oil and vitamin D
1 results
All studies measuring Progression to overt diabetes
Outcome: Progression to overt diabetes
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Curcumin Supplements improve diabetes incidence and prevention?
Emerging Evidence
Curcumin Supplements appears to improve Diabetes Incidence and Prevention.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Progression to overt diabetes
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Curcumin Supplements affect body mass index?
Emerging Evidence
Current evidence does not show a clear benefit of Curcumin Supplements for Body Mass Index.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
- Only a small number of supporting studies are available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Curcumin Supplements improve HbA1c?
Limited Evidence
Current evidence does not show a clear benefit of Curcumin Supplements for HbA1c.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
- Only a small number of supporting studies are available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Curcumin Supplements improve fasting glucose?
Limited Evidence
Current evidence does not show a clear benefit of Curcumin Supplements for Fasting Glucose.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Fasting Plasma Glucose (FPG)
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies and existing graph evidence signals.
Limitations
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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