Last updated August 29, 2026
Key finding
Medication adherence was significantly improved in the intervention group compared with the control group (t116 = 2.27; P = .02, 2-tailed).
This randomized controlled trial evaluated a highly tailored digital intervention aimed at improving medication adherence in patients with hypertension and type 2 diabetes. The intervention significantly enhanced medication adherence and satisfaction among participants.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This randomized controlled trial evaluated a highly tailored digital intervention aimed at improving medication adherence in patients with hypertension and type 2 diabetes. The intervention significantly enhanced medication adherence and satisfaction among participants.
Improving medication adherence is crucial for managing chronic diseases such as hypertension and type 2 diabetes, as it can lead to better health outcomes and reduced healthcare costs. This study highlights the potential of digital interventions to enhance patient engagement and adherence, which is vital for effective disease management.
Limited generalizability due to specific population characteristics Potential biases in self-reported adherence measures Short follow-up period may not capture long-term effects
Published in
Publication details and source links for this paper.
Elizabeth B, Bridget S, Elizeus R, et al. Efficacy of a Highly Tailored Digital Intervention to Support Medication Adherence in Patients with Hypertension and Type 2 Diabetes: A Randomized Controlled Trial. Journal of Medical Internet Research. 2020;22(5):e16629. doi:10.2196/16629
Medication adherence improved by 0.49 days (P = 0.02)
Percentage adherence increased by 4.74% (P = 0.05)
Repeat prescription adherence improved by 0.07 prescriptions (P = 0.02)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Highly tailored digital intervention and Adherence to aspirin, Engagement duration with the intervention, Erythrocyte sedimentation rate, and 5 more.
This study contributes evidence to
Primary intervention
Highly tailored digital intervention
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
8
Evidence pairs
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Related studies
Core evidence
The primary outcomes reported in this study.
Highly tailored digital intervention → Adherence to aspirin
Highly tailored digital intervention → Adherence to aspirin
Highly tailored digital intervention → Engagement duration with the intervention
Highly tailored digital intervention → Engagement duration with the intervention
Highly tailored digital intervention → Erythrocyte sedimentation rate
Highly tailored digital intervention → Erythrocyte sedimentation rate
Highly tailored digital intervention → Fidelity of mHealth intervention
Highly tailored digital intervention → Fidelity of mHealth intervention
Highly tailored digital intervention → Parent satisfaction score regarding diabetes intervention
Highly tailored digital intervention → Parent satisfaction score regarding diabetes intervention
Highly tailored digital intervention → Percentage of medication adherence in the last month
Highly tailored digital intervention → Percentage of medication adherence in the last month
Highly tailored digital intervention → Reduction in Hemoglobin A1C levels
Highly tailored digital intervention → Reduction in Hemoglobin A1C levels
Highly tailored digital intervention → Systolic blood pressure
Highly tailored digital intervention → Systolic blood pressure
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Highly tailored digital intervention and Treatment Adherence, Highly tailored digital intervention and Engagement duration with the intervention.
This study contributes to the evidence on the following intervention-outcome relationships.
Devices & Technology
Devices & Technology
Devices & Technology
Curated evidence collections and hubs this study is part of.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies measuring Engagement duration with the intervention
Measures Engagement duration with the intervention as a key outcome.
All studies on Highly tailored digital intervention
Contributes to Highly tailored digital intervention evidence base.
All studies measuring Treatment Adherence
Measures Treatment Adherence as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Highly tailored digital intervention appears to improve Adherence to aspirin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adherence to aspirin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Highly tailored digital intervention appears to improve Engagement duration with the intervention.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Engagement duration with the intervention
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Highly tailored digital intervention appears to improve Erythrocyte sedimentation rate.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Erythrocyte sedimentation rate
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Highly tailored digital intervention appears to improve Fidelity of mHealth intervention.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fidelity of mHealth intervention
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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