Last updated August 21, 2026
Key finding
Eighty-nine percent of participants completed the 12-week dietary intervention.
This pilot study evaluated the combination of dulaglutide and a low energy diet in individuals with type 2 diabetes and obesity, finding significant weight loss and HbA1c reduction.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This pilot study evaluated the combination of dulaglutide and a low energy diet in individuals with type 2 diabetes and obesity, finding significant weight loss and HbA1c reduction.
These findings suggest that combining dulaglutide with a low energy diet could be an effective strategy for managing obesity and glycemic control in individuals with type 2 diabetes. This approach may offer a new avenue for treatment, especially in populations struggling with weight management.
The study had a small sample size. Results may not be generalizable to all populations. Quality of life metrics showed no significant change.
Published in
Publication details and source links for this paper.
James ADS, Simon Y, Francois V, Carl P. Combination of dulaglutide and low energy diet in individuals with type 2 diabetes and obesity: a pilot study. BMJ Nutrition, Prevention & Health. 2023;6(2):341-346. doi:10.1136/bmjnph-2023-000733
Eighty-nine percent of participants completed the dietary intervention.
Participants achieved an average weight loss of 9.5 kg.
Mean reduction in HbA1c was 15.8 mmol/mol.
Quality of life metrics remained unchanged.
Evidence network
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This study contributes evidence to Combination of dulaglutide and low energy diet and Adverse events incidence, HbA1c, Proportion of participants completing the dietary intervention, and 2 more.
This study contributes evidence to
Primary intervention
Combination of dulaglutide and low energy diet
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
5
Evidence pairs
999
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Combination of dulaglutide and low energy diet → Adverse events incidence
Combination of dulaglutide and low energy diet → Adverse events incidence
Combination of dulaglutide and low energy diet → HbA1c
Combination of dulaglutide and low energy diet → HbA1c
Combination of dulaglutide and low energy diet → Proportion of participants completing the dietary intervention
Combination of dulaglutide and low energy diet → Proportion of participants completing the dietary intervention
Combination of dulaglutide and low energy diet → Quality of life
Combination of dulaglutide and low energy diet → Quality of life
Combination of dulaglutide and low energy diet → Weight change
Combination of dulaglutide and low energy diet → Weight change
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Combination of dulaglutide and low energy diet and Adverse events incidence, Combination of dulaglutide and low energy diet and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Adverse events incidence
Measures Adverse events incidence as a key outcome.
All studies on Combination of dulaglutide and low energy diet
Contributes to Combination of dulaglutide and low energy diet evidence base.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Combination of dulaglutide and low energy diet appears to lower HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Combination of dulaglutide and low energy diet appears to improve proportion of participants completing the dietary intervention.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Proportion of participants completing the dietary intervention
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Combination of dulaglutide and low energy diet appears to improve weight change.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Weight change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear reduction in adverse events incidence with Combination of dulaglutide and low energy diet.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adverse events incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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