Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Glycocalyx supplementation improves microvascular health in type 2 diabetes
Last updated September 10, 2026
Key finding
The major treatment effect on microvascular health was worsening for RBC-velocity independent PBR dynamic, especially at follow-up.
This study evaluated dietary interventions to improve microvascular function in South-Asian patients with type 2 diabetes, finding mixed results.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated dietary interventions to improve microvascular function in South-Asian patients with type 2 diabetes, finding mixed results.
Clinical relevance
Improving microvascular function is crucial for managing complications in diabetes. This study highlights the potential of dietary interventions, particularly glycocalyx supplementation, to enhance vascular health in a population at high risk for diabetes-related complications.
Keep in mind
Unclear effectiveness of interventions. Limited generalizability due to specific population. Lack of long-term follow-up data.
Published in
Journal Reference
Publication details and source links for this paper.
Anouk IMVDV, Daphne HTI, Prataap KCS, et al. Dietary interventions to stabilize microvascular function in South-Asian patients with type 2 diabetes. Nutrition & Diabetes. 2024;14:17. doi:10.1038/s41387-024-00275-5
Main Effects
Glycocalyx supplementation improved PBR dynamic.
Glycocalyx supplementation reduced urinary MCP-1 presence.
Fasting mimicking diet showed temporary improvements in BMI and HbA1c.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Fasting mimicking diet (FMD, Prolon), Glycocalyx mimetic supplementation (Endocalyx) and BMI, HbA1c, Red blood cell velocity independent PBR dynamic, and 3 more.
This study contributes evidence to
Primary intervention
Fasting mimicking diet (FMD, Prolon)
Primary outcomes
- BMI
- HbA1c
- Red blood cell velocity independent PBR dynamic
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 64
2
Related topics
6
Evidence pairs
876
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
HbA1c Reduction
matched_outcome
Related evidence
Evidence topic
Weight Loss
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerRed blood cell velocity independent PBR dynamic
Fasting mimicking diet (FMD, Prolon) → Red blood cell velocity independent PBR dynamic
Fasting mimicking diet (FMD, Prolon) → Red blood cell velocity independent PBR dynamic
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerMicrovascular Health Score (MVHS) dynamic
Glycocalyx mimetic supplementation (Endocalyx) → Microvascular Health Score (MVHS) dynamic
Glycocalyx mimetic supplementation (Endocalyx) → Microvascular Health Score (MVHS) dynamic
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerReduction in Perfused Boundary Region (PBR) at 12 months
Glycocalyx mimetic supplementation (Endocalyx) → Reduction in Perfused Boundary Region (PBR) at 12 months
Glycocalyx mimetic supplementation (Endocalyx) → Reduction in Perfused Boundary Region (PBR) at 12 months
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerUrinary MCP-1 presence
Glycocalyx mimetic supplementation (Endocalyx) → Urinary MCP-1 presence
Glycocalyx mimetic supplementation (Endocalyx) → Urinary MCP-1 presence
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Glycocalyx supplementation improved microvascular health measures.
- Fasting mimicking diet had only short-term effects on BMI and HbA1c.
- Urinary MCP-1 presence was reduced with glycocalyx supplementation.
Who this applies to
- South-Asian adults with type 2 diabetes.
- Patients at risk for microvascular complications.
Keep in Mind
- Results may not apply to non-South-Asian populations.
- Short follow-up limits understanding of long-term effects.
- Further research is needed to clarify effectiveness.
Between the Lines
- Unclear effectiveness of interventions.
- Limited generalizability due to specific population.
- Lack of long-term follow-up data.
Evidence Library
Build your evidence library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Fasting mimicking diet (FMD, Prolon) and Body Mass Index, Fasting mimicking diet (FMD, Prolon) and HbA1c.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Fasting mimicking diet (FMD, Prolon) → Body Mass Index
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceDiet and Nutrition
Fasting mimicking diet (FMD, Prolon) → HbA1c
Diet and Nutrition
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
1 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Fasting mimicking diet (FMD, Prolon) Evidence Hub
All studies on Fasting mimicking diet (FMD, Prolon)
1 studies
intervention_hubContributes to Fasting mimicking diet (FMD, Prolon) evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
1 studies
outcome_hubMeasures HbA1c as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Fasting mimicking diet (FMD, Prolon) and BMI
Intervention: Fasting mimicking diet (FMD, Prolon)Outcome: BMI
1 results
All studies on Fasting mimicking diet (FMD, Prolon) and HbA1c
Intervention: Fasting mimicking diet (FMD, Prolon)Outcome: HbA1c
1 results
All studies on Fasting mimicking diet (FMD, Prolon)
Intervention: Fasting mimicking diet (FMD, Prolon)
1 results
All studies measuring BMI
Outcome: BMI
1 results
All studies measuring HbA1c
Outcome: HbA1c
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Glycocalyx mimetic supplementation (Endocalyx) improve microvascular health score (MVHS) dynamic?
Emerging Evidence
Glycocalyx mimetic supplementation (Endocalyx) appears to improve microvascular health score (MVHS) dynamic.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Microvascular Health Score (MVHS) dynamic
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
What evidence is available on Glycocalyx mimetic supplementation (Endocalyx) and reduction in perfused boundary region (PBR) at 12 months?
Emerging Evidence
Glycocalyx mimetic supplementation (Endocalyx) appears to reduce reduction in perfused boundary region (PBR) at 12 months.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Reduction in Perfused Boundary Region (PBR) at 12 months
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Glycocalyx mimetic supplementation (Endocalyx) improve urinary mcp-1 presence?
Emerging Evidence
Glycocalyx mimetic supplementation (Endocalyx) appears to improve urinary mcp-1 presence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Urinary MCP-1 presence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Fasting mimicking diet (FMD, Prolon) affect BMI?
Emerging Evidence
Current evidence does not show a clear effect of Fasting mimicking diet (FMD, Prolon) on BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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Evidence topics
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All studies on Fasting mimicking diet (FMD, Prolon) and Red blood cell velocity independent PBR dynamicAll studies on Glycocalyx mimetic supplementation (Endocalyx) and Microvascular Health Score (MVHS) dynamicAll studies on Glycocalyx mimetic supplementation (Endocalyx) and Reduction in Perfused Boundary Region (PBR) at 12 monthsAll studies on Glycocalyx mimetic supplementation (Endocalyx) and Urinary MCP-1 presence
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