Research Summary
Analyzed using Evidence Intelligence™

Increased fish intake does not harm glucose metabolism

Last updated July 18, 2026

Key finding

Fasting plasma CMPF concentration was significantly increased after a 12-week consumption of fatty fish three times per week.

This study investigated the impact of fatty fish consumption on plasma CMPF concentration and glucose metabolism in individuals with impaired glucose metabolism. Results indicated that increased fish consumption did not correlate with impaired glucose metabolism.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study investigated the impact of fatty fish consumption on plasma CMPF concentration and glucose metabolism in individuals with impaired glucose metabolism. Results indicated that increased fish consumption did not correlate with impaired glucose metabolism.

Clinical relevance

Understanding the relationship between dietary habits and metabolic health is crucial, especially for individuals with impaired glucose metabolism. The findings indicate that increasing fish intake may be beneficial without adverse effects on glucose control, potentially guiding dietary recommendations for managing metabolic health.

Keep in mind

Effectiveness of interventions remains unclear due to limited data. The study may not be generalizable to all populations with glucose metabolism issues. Sample size and participant diversity were not specified.

Published in

Journal Reference

Publication details and source links for this paper.

Maria AL, Kati H, Marjukka K, et al. Plasma CMPF Concentration and Glucose Metabolism in Persons with Impaired Glucose Metabolism. PLOS ONE. 2015;10(4):e0124379. doi:10.1371/journal.pone.0124379

Main Effects

Fasting plasma CMPF concentration significantly increased by 1 μM after 12 weeks of consuming fatty fish three times per week.

Increases in plasma CMPF concentrations were not associated with impaired glucose metabolism.

2-hour insulin concentration during OGTT showed a decrease of -12.3 mU/L with a p-value of 0.038.

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Habitual intake of fish, Three meals of fatty fish per week and Fasting plasma CMPF concentration, Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration.

Primary intervention

Habitual intake of fish

Primary outcomes

  • Fasting plasma CMPF concentration
  • Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

3
Evidence pairs
3
Relationships
0
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 50

0

Related topics

3

Evidence pairs

0

Related studies

Why it is useful

  • Contributes to 3 evidence relationships
  • Includes primary outcome data
  • Linked to 0 direct semantic evidence topics

Core evidence

Study findings

The primary outcomes reported in this study.

Fasting plasma CMPF concentration

Habitual intake of fish → Fasting plasma CMPF concentration

Habitual intake of fish → Fasting plasma CMPF concentration

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration

Three meals of fatty fish per week → Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration

Three meals of fatty fish per week → Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Fasting plasma CMPF concentration

Three meals of fatty fish per week → Fasting plasma CMPF concentration

Three meals of fatty fish per week → Fasting plasma CMPF concentration

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Evidence Library

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evidence suggest

Evidence Suggest

  • Fatty fish consumption raised plasma CMPF by 1 μM.
  • No association found between increased CMPF and impaired glucose metabolism.
  • Insulin levels decreased by -12.3 mU/L, indicating potential metabolic benefits.
who this applies

Who this applies to

  • Individuals with impaired glucose metabolism.
  • Adults looking to improve dietary habits related to fish intake.
keep in mind

Keep in Mind

  • The study's findings may not apply to populations outside the specific participant group.
  • Further research is needed to confirm long-term effects of fish consumption on glucose metabolism.
  • The effectiveness of dietary interventions was not definitively established.
between the lines

Between the Lines

  • Effectiveness of interventions remains unclear due to limited data.
  • The study may not be generalizable to all populations with glucose metabolism issues.
  • Sample size and participant diversity were not specified.

Evidence Library

Build your evidence library

Save research, organize studies, and quickly find important evidence again.

Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Habitual intake of fish and Fasting plasma CMPF concentration, Three meals of fatty fish per week and Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Included in these evidence collections

Curated evidence collections and hubs this study is part of.

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Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Three meals of fatty fish per week improve fasting plasma cmpf concentration?

Emerging Evidence

Three meals of fatty fish per week appears to improve Fasting plasma CMPF concentration.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Fasting plasma CMPF concentration

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Consistency cannot yet be determined.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026

Does Habitual intake of fish improve fasting plasma cmpf concentration?

Emerging Evidence

Current evidence does not show a clear benefit of Habitual intake of fish for Fasting plasma CMPF concentration.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Fasting plasma CMPF concentration

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Consistency cannot yet be determined.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026

Does Three meals of fatty fish per week improve decreased 2-hour insulin concentration in ogtt associated with elevated plasma cmpf concentration?

Emerging Evidence

Current evidence does not show a clear benefit of Three meals of fatty fish per week for Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Consistency cannot yet be determined.
  • Population details are unavailable.
1 supporting studyUpdated: Jul 2026
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