Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Family-Based Intervention May Reduce T2DM Risk Factors in Women with GDM
Last updated September 9, 2026
Key finding
Analyses of secondary and tertiary outcomes indicated significantly lower 2-hour insulin (−94.3 pmmol/L; 95% CI −167.9 to −20.6) levels in the intervention group.
This study evaluated a family-based health promotion intervention aimed at reducing T2DM risk factors among women with recent GDM. It found significant reductions in 2-hour insulin levels, triglycerides, and odds of elevated fasting plasma glucose.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated a family-based health promotion intervention aimed at reducing T2DM risk factors among women with recent GDM. It found significant reductions in 2-hour insulin levels, triglycerides, and odds of elevated fasting plasma glucose.
Clinical relevance
These findings highlight the potential of family-based interventions in managing diabetes risk factors among women with a history of gestational diabetes. By effectively lowering insulin and triglyceride levels, such programs may help prevent the onset of type 2 diabetes, which is crucial for improving long-term health outcomes in this population.
Keep in mind
The study's effectiveness remains unclear for some outcomes. Results may not be generalizable beyond the study population. Sample size and follow-up duration may limit the findings.
Published in
Journal Reference
Publication details and source links for this paper.
Karoline KN, Inger KD, Dorte MJ, et al. Effectiveness of a Family-Based Health Promotion Intervention on T2DM Risk Factors Among Women with Recent GDM. The Journal of Clinical Endocrinology and Metabolism. 2025;110(8):e2456-e2470. doi:10.1210/clinem/dgae856
Main Effects
The intervention did not significantly lower BMI (−0.44 kg/m²; 95% CI −0.98 to 0.11).
Quality of life (SF12 MCS) did not improve (0.06; 95% CI −2.15 to 2.27).
2-hour insulin levels significantly decreased (−94.3 pmmol/L; 95% CI −167.9 to −20.6).
Triglycerides significantly decreased (−0.18 mmol/L; 95% CI −0.30 to −0.05).
Odds of fasting plasma glucose ≥6.1 mmol/L were reduced (odds ratio 0.33; 95% CI 0.12 to 0.91).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Family-based health promotion intervention and BMI, Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration, Fasting blood sugar (FBS), and 2 more.
This study contributes evidence to
Primary intervention
Family-based health promotion intervention
Primary outcomes
- BMI
- Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
- Fasting blood sugar (FBS)
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
5
Evidence pairs
5
Relationships
4
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
4
Related topics
5
Evidence pairs
1255
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 5 evidence relationships
- Includes primary outcome data
- Linked to 4 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Fasting Blood Glucose
matched_outcome
Related evidence
Evidence topic
Glycemic Control
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
Family-based health promotion intervention → Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
Family-based health promotion intervention → Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerFasting blood sugar (FBS)
Family-based health promotion intervention → Fasting blood sugar (FBS)
Family-based health promotion intervention → Fasting blood sugar (FBS)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerQuality of life
Family-based health promotion intervention → Quality of life
Family-based health promotion intervention → Quality of life
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerTriglycerides
Family-based health promotion intervention → Triglycerides
Family-based health promotion intervention → Triglycerides
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- The intervention significantly reduced 2-hour insulin levels by 94.3 pmmol/L.
- Triglycerides decreased by 0.18 mmol/L in the intervention group.
- Odds of elevated fasting plasma glucose were reduced by 67%.
Who this applies to
- Women with recent gestational diabetes mellitus (GDM).
- Individuals at risk for developing type 2 diabetes.
Keep in Mind
- The intervention did not significantly impact BMI or quality of life.
- Results may not apply to women outside the study's demographic.
- Long-term effects of the intervention were not assessed.
Between the Lines
- The study's effectiveness remains unclear for some outcomes.
- Results may not be generalizable beyond the study population.
- Sample size and follow-up duration may limit the findings.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Family-based health promotion intervention and Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration, Family-based health promotion intervention and Body Mass Index.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Family-based health promotion intervention → Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceBehavioral & Lifestyle
Family-based health promotion intervention → Body Mass Index
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceBehavioral & Lifestyle
Family-based health promotion intervention → Quality of Life Outcomes
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
1 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration Evidence Hub
All studies measuring Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
1 studies
outcome_hubMeasures Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration as a key outcome.
Family-based health promotion intervention Evidence Hub
All studies on Family-based health promotion intervention
1 studies
intervention_hubContributes to Family-based health promotion intervention evidence base.
Quality of Life Outcomes Evidence Hub
All studies measuring Quality of Life Outcomes
1 studies
outcome_hubMeasures Quality of Life Outcomes as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
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All studies on Family-based health promotion intervention and Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
Intervention: Family-based health promotion interventionOutcome: Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
1 results
All studies on Family-based health promotion intervention and BMI
Intervention: Family-based health promotion interventionOutcome: BMI
1 results
All studies on Family-based health promotion intervention
Intervention: Family-based health promotion intervention
1 results
All studies measuring Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
Outcome: Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
1 results
All studies measuring BMI
Outcome: BMI
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Family-based health promotion intervention improve decreased 2-hour insulin concentration in ogtt associated with elevated plasma cmpf concentration?
Emerging Evidence
Family-based health promotion intervention appears to improve decreased 2-hour insulin concentration in ogtt associated with elevated plasma cmpf concentration.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentration
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Family-based health promotion intervention improve fasting blood sugar (FBS)?
Emerging Evidence
Family-based health promotion intervention appears to improve fasting blood sugar (FBS).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Family-based health promotion intervention improve triglycerides?
Emerging Evidence
Family-based health promotion intervention appears to improve triglycerides.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Triglycerides
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Family-based health promotion intervention affect BMI?
Emerging Evidence
Current evidence does not show a clear effect of Family-based health promotion intervention on BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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All studies on Family-based health promotion intervention and BMIAll studies on Family-based health promotion intervention and Quality of lifeAll studies on Family-based health promotion intervention and Decreased 2-hour insulin concentration in OGTT associated with elevated plasma CMPF concentrationAll studies on Family-based health promotion intervention and Fasting blood sugar (FBS)
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