Last updated July 6, 2026
Key finding
Intensive glycemic control was associated with lower MACE in pooled study data.
This study examined the effects of intensive versus standard glycemic control on cardiovascular events in type 2 diabetes patients, finding no significant differences in certain outcomes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
Save research, organize studies, and quickly find important evidence again.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the effects of intensive versus standard glycemic control on cardiovascular events in type 2 diabetes patients, finding no significant differences in certain outcomes.
Understanding the varying effects of glycemic control on cardiovascular outcomes is crucial for tailoring diabetes management strategies. This study highlights the need for personalized treatment approaches, as intensive glycemic control may not benefit all patients equally, potentially guiding clinicians in making informed decisions about diabetes care.
Effectiveness of interventions was unclear in some cases. Results may not be generalizable to all populations. Subgroup analyses had varying outcomes, complicating interpretations.
Published in
Publication details and source links for this paper.
Justin AE, Kevin J, Gideon B, et al. Heterogeneous Treatment Effects of Intensive Glycemic Control on Major Adverse Cardiovascular Events in Type 2 Diabetes Patients. Cardiovascular Diabetology. 2022;21:58. doi:10.1186/s12933-022-01496-7
Intensive glycemic control was associated with a 4.2% decrease in composite cardiovascular events in pooled data.
No significant difference in composite cardiovascular events was noted in some subgroups.
All-cause mortality rates showed no significant difference between the two treatment groups.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Intensive glycemic control, Standard glycemic control and All-cause mortality, Composite cardiovascular events (CV death, MI, stroke, HF hospitalization).
This study contributes evidence to
Primary intervention
Intensive glycemic control
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
3
Evidence pairs
44
Related studies
Evidence topic
Contributes evidence
Save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.
Primary evidence
Evidence relationship
Related evidence
Evidence topic
Save evidence
Intervention
Save evidence
Core evidence
The primary outcomes reported in this study.
Intensive glycemic control → All-cause mortality
Intensive glycemic control → All-cause mortality
Intensive glycemic control → Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Intensive glycemic control → Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Standard glycemic control → Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Standard glycemic control → Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Glycemic Control Treatments and Cardiovascular Outcomes, Glycemic Control Treatments and Cardiovascular Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Cardiovascular Outcomes
Measures Cardiovascular Outcomes as a key outcome.
All studies on Glycemic Control Treatments
Contributes to Glycemic Control Treatments evidence base.
Jump to pre-filtered views in Evidence Explorer.
2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Glycemic Control Treatments may improve Cardiovascular Outcomes.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Composite cardiovascular events (CV death, MI, stroke, HF hospitalization)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Mixed | 1 study
All-cause mortality
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Focused on evidence, not advertising.
Your data is always protected.
New studies added every day.
