Last updated July 11, 2026
Key finding
Fasting blood glucose levels were significantly reduced in the T2DM-RD-L group compared to the T2DM-C group (P < 0.05).
This study investigated the effects of Lactobacillus johnsonii supplementation on blood glucose control in individuals with Type 2 Diabetes and circadian rhythm disruption, finding significant improvements in several metabolic parameters.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of Lactobacillus johnsonii supplementation on blood glucose control in individuals with Type 2 Diabetes and circadian rhythm disruption, finding significant improvements in several metabolic parameters.
These findings are significant as they suggest that Lactobacillus johnsonii could be a beneficial adjunct therapy for managing blood glucose and lipid levels in patients with Type 2 Diabetes, particularly those experiencing circadian rhythm disruptions. Improved metabolic control can lead to better overall health outcomes and reduce the risk of diabetes-related complications.
Non-randomized design may introduce bias. Limited generalizability due to specific population characteristics. Potential confounding factors not controlled for.
Published in
Publication details and source links for this paper.
Yang Y, Wang Z, Shen H, et al. Lactobacillus johnsonii Improves Blood Glucose Control in Type 2 Diabetes with Circadian Rhythm Disruption. Scientific Reports. 2026;16:16220. doi:10.1038/s41598-025-94359-6
Fasting plasma glucose levels decreased by 2.5 mmol/L (P < 0.05).
Postprandial blood glucose levels were significantly reduced.
Total cholesterol levels decreased significantly (P < 0.05).
High-density lipoprotein levels increased by 0.3 mmol/L (P < 0.05).
Evidence network
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This study contributes evidence to Lactobacillus johnsonii supplementation and Fasting Plasma Glucose (FPG), Glucose iAUC (OGTT), High-density lipoprotein, and 2 more.
This study contributes evidence to
Primary intervention
Lactobacillus johnsonii supplementation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
5
Evidence pairs
245
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Lactobacillus johnsonii supplementation → Fasting Plasma Glucose (FPG)
Lactobacillus johnsonii supplementation → Fasting Plasma Glucose (FPG)
Lactobacillus johnsonii supplementation → Glucose iAUC (OGTT)
Lactobacillus johnsonii supplementation → Glucose iAUC (OGTT)
Lactobacillus johnsonii supplementation → High-density lipoprotein
Lactobacillus johnsonii supplementation → High-density lipoprotein
Lactobacillus johnsonii supplementation → Low-density lipoprotein
Lactobacillus johnsonii supplementation → Low-density lipoprotein
Lactobacillus johnsonii supplementation → Total cholesterol
Lactobacillus johnsonii supplementation → Total cholesterol
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lactobacillus johnsonii supplementation and Fasting Glucose, Lactobacillus johnsonii supplementation and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Lactobacillus johnsonii supplementation
Contributes to Lactobacillus johnsonii supplementation evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Lactobacillus johnsonii supplementation appears to improve Fasting Plasma Glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lactobacillus johnsonii supplementation appears to improve Glucose iAUC (OGTT).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Glucose iAUC (OGTT)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lactobacillus johnsonii supplementation appears to improve High-density lipoprotein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
High-density lipoprotein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Lactobacillus johnsonii supplementation appears to improve Low-density lipoprotein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Low-density lipoprotein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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