StrongDecrease
HbA1c
Digital-based lifestyle intervention → HbA1c
Digital-based lifestyle intervention → HbA1c
Evidence profile
StrongDecreaseGlycemic Control
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Research Summary
Analyzed using Evidence Intelligence™
Mebix App Improves Glycemic Control in Type 2 Diabetes
Key finding
Participants using mebix achieved a statistically significant reduction in HbA1c levels by 0.82 percentage points.
This study evaluated the app-based intervention Mebix for individuals with Type 2 diabetes, finding significant improvements in HbA1c levels, weight loss, and diabetes-related distress compared to a placebo app.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Some Concerns bias
Last updated July 8, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Mebix (app-based intervention), Placebo app
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
HbA1c
Comparator
Control Group (Placebo App)
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study evaluated the app-based intervention Mebix for individuals with Type 2 diabetes, finding significant improvements in HbA1c levels, weight loss, and diabetes-related distress compared to a placebo app.
Clinical relevance
These findings are clinically significant as they suggest that digital health interventions like Mebix can effectively support diabetes management, potentially leading to better health outcomes and improved quality of life for individuals with Type 2 diabetes.
Keep in mind
The study's sample size and demographic characteristics may limit generalizability. Potential biases in self-reported measures could affect outcome accuracy. The long-term effects of the intervention were not assessed.
Published in
Journal Reference
Publication details and source links for this paper.
Lena R, Maxi PB, Peter EHS. Evaluation of the App-Based Intervention Mebix for People with Type 2 Diabetes: A Randomized Controlled Trial. Frontiers in Digital Health. 2025;7:1644612. doi:10.3389/fdgth.2025.1644612
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Main Effects
Mebix users achieved a significant reduction in HbA1c levels by 0.82 percentage points (p=0.003).
Participants using Mebix experienced a weight loss of 1.6 kg (p=0.012).
Mebix users reported a decrease in diabetes-related distress by 8.38 points (p=0.001).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Digital-based lifestyle intervention and HbA1c, Stress, Weight change.
This study contributes evidence to
Primary intervention
Digital-based lifestyle intervention
Primary outcomes
- HbA1c
- Stress
- Weight change
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
3
Evidence pairs
3
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 69
3
Related topics
3
Evidence pairs
316
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 3 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
StrongDecrease
Stress
Digital-based lifestyle intervention → Stress
Digital-based lifestyle intervention → Stress
Evidence profile
StrongDecreasePatient-Reported
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StrongDecrease
Weight change
Digital-based lifestyle intervention → Weight change
Digital-based lifestyle intervention → Weight change
Evidence profile
StrongDecreaseWeight & Anthropometrics
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Evidence Suggest
- Mebix led to a significant HbA1c reduction of 0.82 percentage points.
- Users lost an average of 1.6 kg compared to the placebo group.
- Diabetes-related distress decreased by 8.38 points in the Mebix group.
Who this applies to
- Adults diagnosed with Type 2 diabetes.
- Individuals seeking digital health solutions for diabetes management.
Keep in Mind
- Results may not apply to populations outside the study's demographic.
- Further research is needed to confirm long-term effectiveness.
- The study did not include a diverse range of participants.
Between the Lines
- The study's sample size and demographic characteristics may limit generalizability.
- Potential biases in self-reported measures could affect outcome accuracy.
- The long-term effects of the intervention were not assessed.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Digital-based lifestyle intervention and HbA1c, Digital-based lifestyle intervention and Body Weight.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Weight Evidence Hub
All studies measuring Body Weight
2 studies
outcome_hubMeasures Body Weight as a key outcome.
Digital-based lifestyle intervention Evidence Hub
All studies on Digital-based lifestyle intervention
2 studies
intervention_hubContributes to Digital-based lifestyle intervention evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
2 studies
outcome_hubMeasures HbA1c as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Digital-based lifestyle intervention and HbA1c
Intervention: Digital-based lifestyle interventionOutcome: HbA1c
2 results
All studies on Digital-based lifestyle intervention and Weight change
Intervention: Digital-based lifestyle interventionOutcome: Weight change
2 results
All studies on Digital-based lifestyle intervention
Intervention: Digital-based lifestyle intervention
2 results
All studies measuring HbA1c
Outcome: HbA1c
2 results
All studies measuring Weight change
Outcome: Weight change
2 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Digital-based lifestyle intervention improve HbA1c?
Emerging Evidence
Digital-based lifestyle intervention appears to improve HbA1c.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 56.5 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Digital-based lifestyle intervention improve weight change?
Emerging Evidence
Digital-based lifestyle intervention appears to improve Weight change.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Weight change
EvidenceScore™ Emerging | EvidenceScore™ 56.5 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Digital-based lifestyle intervention improve stress?
Emerging Evidence
Digital-based lifestyle intervention appears to improve Stress.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Stress
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
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