Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Melatonin shows no effect on diabetes risk markers in night workers
Last updated August 16, 2026
Key finding
There was no significant difference in blood glucose levels between groups (p=0.36).
This study investigated the effects of melatonin on diabetes risk markers in night workers, finding no significant differences between melatonin and placebo groups.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of melatonin on diabetes risk markers in night workers, finding no significant differences between melatonin and placebo groups.
Clinical relevance
Understanding the impact of melatonin on diabetes risk markers is crucial for night workers, who may be at higher risk due to disrupted sleep patterns. This study's findings suggest that melatonin may not be an effective intervention for managing diabetes risk in this population, highlighting the need for alternative strategies.
Keep in mind
Limited sample size may affect the generalizability of results. Study population consisted solely of night workers, limiting applicability to other groups. No long-term follow-up to assess lasting effects of melatonin.
Published in
Journal Reference
Publication details and source links for this paper.
Carlos ARDS, Luciana FN, José C, Claudia RDCM, Elaine CM. Melatonin Administration and Diabetes Risk Markers in Night Workers: A Randomized Controlled Trial. Frontiers in Nutrition. 2024;11:1285398. doi:10.3389/fnut.2024.1285398
Main Effects
No significant difference in blood glucose levels between melatonin and placebo groups (p=0.36).
No significant difference in insulin levels between groups (p=0.67).
No significant difference in HbA1c levels between groups (p=0.79).
No significant difference in insulin resistance (HOMA-IR) between groups (p=0.50).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Melatonin and Blood glucose, HbA1c, Insulin, and 1 more.
This study contributes evidence to
Primary intervention
Melatonin
Primary outcomes
- Blood glucose
- HbA1c
- Insulin
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
4
Evidence pairs
4
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 64
2
Related topics
4
Evidence pairs
622
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 4 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Glycemic Control
matched_outcome
Related evidence
Evidence topic
HbA1c Reduction
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- 77
- Strong
- ImpactScore™
- 67
- Slightly Positive
- ConsistencyScore™
- 67
- generally_consistent
Supporting studies: Based on 3 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Melatonin did not significantly lower blood glucose levels (p=0.36).
- Insulin levels remained unchanged with melatonin compared to placebo (p=0.67).
- HbA1c levels showed no significant difference between groups (p=0.79).
Who this applies to
- Night workers potentially at risk for diabetes.
- Individuals seeking interventions for diabetes risk management.
Keep in Mind
- Results may not apply to populations outside of night workers.
- Short duration of the study limits understanding of long-term effects.
- Lack of significant findings suggests further research is needed.
Between the Lines
- Limited sample size may affect the generalizability of results.
- Study population consisted solely of night workers, limiting applicability to other groups.
- No long-term follow-up to assess lasting effects of melatonin.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Melatonin and HbA1c, Melatonin and Insulin Resistance.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Melatonin → HbA1c
Supplements
Evidence Intelligence™
- EvidenceScore™
- 77
- Strong
- ImpactScore™
- 67
- Slightly Positive
- ConsistencyScore™
- 67
- generally_consistent
Supporting studies: Based on 3 studies
View evidenceSupplements
Melatonin → Insulin Resistance
Supplements
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 2 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
3 studies
outcome_hubMeasures HbA1c as a key outcome.
Melatonin Evidence Hub
All studies on Melatonin
3 studies
intervention_hubContributes to Melatonin evidence base.
Insulin Resistance Evidence Hub
All studies measuring Insulin Resistance
2 studies
outcome_hubMeasures Insulin Resistance as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Melatonin and HbA1c
Intervention: MelatoninOutcome: HbA1c
3 results
All studies on Melatonin and Insulin resistance
Intervention: MelatoninOutcome: Insulin resistance
2 results
All studies on Melatonin
Intervention: Melatonin
3 results
All studies measuring HbA1c
Outcome: HbA1c
3 results
All studies measuring Insulin resistance
Outcome: Insulin resistance
2 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Melatonin improve HbA1c?
Strong Evidence
Melatonin may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 77.4 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Melatonin improve insulin resistance?
Moderate Evidence
Current evidence does not show a clear benefit of Melatonin for Insulin resistance.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Insulin resistance
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Melatonin improve blood glucose?
Emerging Evidence
Current evidence does not show a clear benefit of Melatonin for Blood glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Melatonin improve insulin?
Emerging Evidence
Current evidence does not show a clear benefit of Melatonin for Insulin.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Insulin
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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