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Research Summary
Analyzed using Evidence Intelligence™

Metformin reduces fetal weight in women with gestational diabetes

Powered by the Dediabetes Evidence Intelligence™ framework

Last updated September 9, 2026

Key finding

P-selectin levels were significantly higher in the metformin group (68.9 ± 14.4 vs 60.6 ± 11.3; P-value = 0.006)

This study investigated the effects of metformin on platelet dysfunction in women with gestational diabetes mellitus, finding significant differences in P-selectin levels and birth weight.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study investigated the effects of metformin on platelet dysfunction in women with gestational diabetes mellitus, finding significant differences in P-selectin levels and birth weight.

Clinical relevance

These findings suggest that metformin may influence platelet function and fetal growth in women with gestational diabetes, which could have important implications for maternal and neonatal health. Understanding these effects is crucial for optimizing treatment strategies and improving outcomes for both mothers and their infants.

Keep in mind

Unclear effectiveness of metformin on other measured outcomes. Limited generalizability due to specific population focus. Potential confounding factors not controlled for in the study.

Published in

Journal Reference

Publication details and source links for this paper.

Panisa H, Rattanaporn S, Thidarat J, et al. The Effect of Metformin on Platelet Dysfunction in Women with Gestational Diabetes Mellitus: A Randomized Controlled Trial. Endocrine Connections. 2022;11(4):e220110. doi:10.1530/EC-22-0110

View DOIView on PubMedView on PMC

Main Effects

P-selectin levels were significantly higher in the metformin group (68.9 ± 14.4 vs 60.6 ± 11.3; P-value = 0.006)

Birth weight was significantly lower in the metformin group (3018 ± 364 g vs 3204 ± 393 g; P-value = 0.037)

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Metformin and Birth weight z score, P-selectin, Urinary 8-isoprostane levels.

This study contributes evidence to

Intervention

Metformin

Outcome

Birth weight z score

Evidence topic

Metformin

Primary intervention

Metformin

Primary outcomes

  • Birth weight z score
  • P-selectin
  • Urinary 8-isoprostane levels

Evidence topics

Metformin

Primary intervention

Metformin

Primary outcomes

Birth weight z scoreP-selectinUrinary 8-isoprostane levels

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

3
Evidence pairs
3
Relationships
1
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 59

1

Related topics

3

Evidence pairs

38

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 3 evidence relationships
  • Includes primary outcome data
  • Linked to 1 direct semantic evidence topic

Topic contributions

Evidence topic

Contributes evidence

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Primary evidence

Evidence topic

Metformin

matched_intervention

Core evidence

Study findings

The primary outcomes reported in this study.

Birth weight z score

Metformin → Birth weight z score

Metformin → Birth weight z score

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
25
Negative
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

P-selectin

Metformin → P-selectin

Metformin → P-selectin

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Urinary 8-isoprostane levels

Metformin → Urinary 8-isoprostane levels

Metformin → Urinary 8-isoprostane levels

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Evidence Library

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evidence suggest

Evidence Suggest

  • Metformin increased P-selectin levels by 8.3 ng/mL (P-value = 0.006).
  • Birth weight decreased by 186 g in the metformin group (P-value = 0.037).
  • No significant change in 8-isoprostane levels (P-value = 0.379).
who this applies

Who this applies to

  • Women diagnosed with gestational diabetes mellitus.
  • Pregnant individuals at risk for platelet dysfunction.
keep in mind

Keep in Mind

  • Results may not apply to women outside the study population.
  • Further research is needed to explore long-term effects.
  • The study did not assess all potential confounding variables.
between the lines

Between the Lines

  • Unclear effectiveness of metformin on other measured outcomes.
  • Limited generalizability due to specific population focus.
  • Potential confounding factors not controlled for in the study.

Evidence Library

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

Powered by the Dediabetes Evidence Intelligence™ framework

This study contributes to evidence on Metformin Therapies and Birth weight z score, Metformin Therapies and P-selectin.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Metformin improve p-selectin?

Emerging Evidence

Current evidence does not show a clear benefit of Metformin for p-selectin.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    P-selectin

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence

Does Metformin improve urinary 8-isoprostane levels?

Emerging Evidence

Current evidence does not show a clear benefit of Metformin for urinary 8-isoprostane levels.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Urinary 8-isoprostane levels

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence

Does Metformin improve birth weight z score?

Emerging Evidence

Metformin may worsen birth weight z score or be associated with harm.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Birth weight z score

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | moderate negative | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
1 supporting study
View Full Evidence
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Next steps

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Evidence topics

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Metformin Evidence Hub

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All studies on Metformin and Birth weight z scoreAll studies on Metformin and P-selectinAll studies on Metformin and Urinary 8-isoprostane levels

Related research

Read related research summaries.

Dietary Modulation of Gut Microbiota in PrediabetesVildagliptin and Metformin Improve Glycemic Control in Type 2 DiabetesEarly use of effective therapies may improve diabetes outcomesMetformin improves glycemic control in adolescents with type 1 diabetesPremeal metformin improves postmeal glucose control in diabetes.

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