Last updated August 21, 2026
Key finding
Patients with low baseline plasma levels of miR-let7b-3p showed a high probability of T2DM remission after the consumption of a low-fat diet.
This study investigated the role of miRNAs in selecting dietary therapies for achieving T2DM remission in patients with coronary heart disease.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the role of miRNAs in selecting dietary therapies for achieving T2DM remission in patients with coronary heart disease.
Understanding how specific miRNA levels influence dietary therapy success can help clinicians tailor interventions for patients with T2DM and coronary heart disease. This personalized approach may enhance remission rates and improve overall patient health, leading to more effective management of diabetes and related cardiovascular risks.
Unclear effectiveness of both dietary interventions due to lack of specific effect sizes. Limited generalizability due to the specific population studied. Potential confounding factors not measured in the study.
Published in
Publication details and source links for this paper.
Juan FA, Antonio C, Cristina V, et al. MiRNAs as a Tool for Selecting Dietary Therapy to Achieve T2DM Remission in Patients with Coronary Heart Disease. Nutrition & Diabetes. 2025;15:7. doi:10.1038/s41387-025-00362-1
Patients with low miR-let7b-3p levels had a high probability of T2DM remission on a low-fat diet.
Patients with high levels of miR-141-5p, miR-182, and miR-192 showed a high probability of T2DM remission on a Mediterranean diet.
No significant differences were found in miRNA levels for non-responders.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Low-fat diet, Mediterranean diet and Baseline Plasma Levels of miR-let7b-3p, T2DM remission after dietary intervention, Baseline plasma levels of miR-192, and 2 more.
This study contributes evidence to
Primary intervention
Low-fat diet
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
6
Evidence pairs
21
Related studies
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Low-fat diet → Baseline Plasma Levels of miR-let7b-3p
Low-fat diet → Baseline Plasma Levels of miR-let7b-3p
Low-fat diet → T2DM remission after dietary intervention
Low-fat diet → T2DM remission after dietary intervention
Mediterranean diet → Baseline plasma levels of miR-192
Mediterranean diet → Baseline plasma levels of miR-192
Mediterranean diet → Plasma arginine levels
Mediterranean diet → Plasma arginine levels
Mediterranean diet → Plasma levels of miR-182
Mediterranean diet → Plasma levels of miR-182
Mediterranean diet → T2DM remission after dietary intervention
Mediterranean diet → T2DM remission after dietary intervention
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Low-fat Diets and Baseline Plasma Levels of miR-let7b-3p, Low-fat Diets and T2DM remission after dietary intervention.
This study contributes to the evidence on the following intervention-outcome relationships.
Diet and Nutrition
Diet and Nutrition
Curated evidence collections and hubs this study is part of.
All studies measuring Baseline Plasma Levels of miR-let7b-3p
Measures Baseline Plasma Levels of miR-let7b-3p as a key outcome.
All studies on Low-fat Diets
Contributes to Low-fat Diets evidence base.
All studies measuring T2DM remission after dietary intervention
Measures T2DM remission after dietary intervention as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Low-fat diet appears to improve t2dm remission after dietary intervention.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
T2DM remission after dietary intervention
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Mediterranean diet appears to improve t2dm remission after dietary intervention.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
T2DM remission after dietary intervention
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Low-fat diet for baseline plasma levels of mir-let7b-3p.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Baseline Plasma Levels of miR-let7b-3p
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Mediterranean diet for baseline plasma levels of mir-192.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Baseline plasma levels of miR-192
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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