NoneNo Change
GLP-1
Mulberry leaf extract (MLE) blend → GLP-1
Mulberry leaf extract (MLE) blend → GLP-1
Evidence profile
NoneNo ChangeMetabolic Health
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Research Summary
Analyzed using Evidence Intelligence™
Natural blend improves glucose response in type 2 diabetes.
Key finding
MLE significantly reduced glucose iAUC at 1 hour by -20% (p < 0.0001).
A blend of mulberry leaf extract, fiber, vitamin D, and chromium in adults with type 2 diabetes.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Extended (5–20+ y)
High bias
Last updated July 8, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Mulberry leaf extract (MLE) blend
Study type
RCTs
Follow-up
Extended (5–20+ y)
Primary outcome
Postprandial glucose iAUC at 1 hour
Comparator
Control blend without MLE
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
A blend of mulberry leaf extract, fiber, vitamin D, and chromium in adults with type 2 diabetes.
Clinical relevance
This study evaluated A blend of mulberry leaf extract, fiber, vitamin D, and chromium in adults with type 2 diabetes.
Keep in mind
Limitations were not clearly described in the extracted text.
Published in
Journal Reference
Publication details and source links for this paper.
Mafauzy M, Roberto LZ, Kalpana B, et al. A randomized controlled exploratory crossover study evaluating a novel natural food adjuvant in individuals with type 2 diabetes. Diabetes Therapy. 2023;14(4):749-766. doi:10.1007/s13300-023-01379-4
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Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Mulberry leaf extract (MLE) blend and GLP-1, Glucose iAUC (OGTT), Incremental area under the curve for postprandial glucose at 2 hours, and 2 more.
This study contributes evidence to
Primary intervention
Mulberry leaf extract (MLE) blend
Primary outcomes
- GLP-1
- Glucose iAUC (OGTT)
- Incremental area under the curve for postprandial glucose at 2 hours
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
5
Evidence pairs
5
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 59
1
Related topics
5
Evidence pairs
109
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 5 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
StrongDecrease
Glucose iAUC (OGTT)
Mulberry leaf extract (MLE) blend → Glucose iAUC (OGTT)
Mulberry leaf extract (MLE) blend → Glucose iAUC (OGTT)
Evidence profile
StrongDecreaseGlycemic Control
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StrongDecrease
Incremental area under the curve for postprandial glucose at 2 hours
Mulberry leaf extract (MLE) blend → Incremental area under the curve for postprandial glucose at 2 hours
Mulberry leaf extract (MLE) blend → Incremental area under the curve for postprandial glucose at 2 hours
Evidence profile
StrongDecreaseGlycemic Control
Unlock full evidence details
StrongDecrease
Postprandial GIP incremental area under the curve (iAUC)
Mulberry leaf extract (MLE) blend → Postprandial GIP incremental area under the curve (iAUC)
Mulberry leaf extract (MLE) blend → Postprandial GIP incremental area under the curve (iAUC)
Evidence profile
StrongDecreaseGlycemic Control
Unlock full evidence details
StrongDecrease
Postprandial insulin AUC
Mulberry leaf extract (MLE) blend → Postprandial insulin AUC
Mulberry leaf extract (MLE) blend → Postprandial insulin AUC
Evidence profile
StrongDecreaseGlycemic Control
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Mulberry leaf extract (MLE) blend and Postprandial and OGTT Glucose, Mulberry leaf extract (MLE) blend and Postprandial GIP incremental area under the curve (iAUC).
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Mulberry leaf extract (MLE) blend Evidence Hub
All studies on Mulberry leaf extract (MLE) blend
1 studies
intervention_hubContributes to Mulberry leaf extract (MLE) blend evidence base.
Postprandial and OGTT Glucose Evidence Hub
All studies measuring Postprandial and OGTT Glucose
1 studies
outcome_hubMeasures Postprandial and OGTT Glucose as a key outcome.
Postprandial GIP incremental area under the curve (iAUC) Evidence Hub
All studies measuring Postprandial GIP incremental area under the curve (iAUC)
1 studies
outcome_hubMeasures Postprandial GIP incremental area under the curve (iAUC) as a key outcome.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Mulberry leaf extract (MLE) blend and Glucose iAUC (OGTT)
Intervention: Mulberry leaf extract (MLE) blendOutcome: Glucose iAUC (OGTT)
1 results
All studies on Mulberry leaf extract (MLE) blend and Postprandial GIP incremental area under the curve (iAUC)
Intervention: Mulberry leaf extract (MLE) blendOutcome: Postprandial GIP incremental area under the curve (iAUC)
1 results
All studies on Mulberry leaf extract (MLE) blend
Intervention: Mulberry leaf extract (MLE) blend
1 results
All studies measuring Glucose iAUC (OGTT)
Outcome: Glucose iAUC (OGTT)
1 results
All studies measuring Postprandial GIP incremental area under the curve (iAUC)
Outcome: Postprandial GIP incremental area under the curve (iAUC)
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Mulberry leaf extract (MLE) blend improve glucose iauc (ogtt)?
Emerging Evidence
Mulberry leaf extract (MLE) blend appears to improve Glucose iAUC (OGTT).
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Glucose iAUC (OGTT)
EvidenceScore™ Emerging | EvidenceScore™ 51.8 | strong positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Mulberry leaf extract (MLE) blend improve incremental area under the curve for postprandial glucose at 2 hours?
Emerging Evidence
Mulberry leaf extract (MLE) blend appears to improve Incremental area under the curve for postprandial glucose at 2 hours.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Incremental area under the curve for postprandial glucose at 2 hours
EvidenceScore™ Emerging | EvidenceScore™ 51.8 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Mulberry leaf extract (MLE) blend improve postprandial gip incremental area under the curve (iauc)?
Emerging Evidence
Mulberry leaf extract (MLE) blend appears to improve Postprandial GIP incremental area under the curve (iAUC).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Postprandial GIP incremental area under the curve (iAUC)
EvidenceScore™ Emerging | EvidenceScore™ 51.8 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Mulberry leaf extract (MLE) blend improve postprandial insulin auc?
Emerging Evidence
Mulberry leaf extract (MLE) blend appears to improve Postprandial insulin AUC.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Postprandial insulin AUC
EvidenceScore™ Emerging | EvidenceScore™ 51.8 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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Explore in archive
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All studies on Mulberry leaf extract (MLE) blend and Glucose iAUC (OGTT)All studies on Mulberry leaf extract (MLE) blend and Incremental area under the curve for postprandial glucose at 2 hoursAll studies on Mulberry leaf extract (MLE) blend and Postprandial GIP incremental area under the curve (iAUC)All studies on Mulberry leaf extract (MLE) blend and Postprandial insulin AUC
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