Research Summary
Analyzed using Evidence Intelligence™

Personalized diet improves glycemic control in type 2 diabetes

Last updated August 22, 2026

Key finding

Average PPGR decreased by 19.8 ± 16.3 mg/dl × h, p < 0.001.

This study evaluated the effects of a personalized postprandial-targeting diet on glycemic control in newly diagnosed type 2 diabetes patients, finding significant reductions in glucose levels.

Quick read

Study at a glance

The essential study design details in one scan.

EvidenceScore™

Moderate

Study type

RCTs

Follow-up

Long-Term (1–5 y)

Risk of bias

Some Concerns

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Plain-language summary

What this paper says

A plain-language read of the study’s main message and where it applies.

Study focus

This study evaluated the effects of a personalized postprandial-targeting diet on glycemic control in newly diagnosed type 2 diabetes patients, finding significant reductions in glucose levels.

Clinical relevance

Improving glycemic control is crucial for managing type 2 diabetes and preventing complications. This study suggests that personalized dietary interventions can effectively lower blood sugar levels, providing a potential strategy for clinicians to enhance patient outcomes in diabetes management.

Keep in mind

Limited generalizability due to specific population characteristics. Potential biases in self-reported dietary adherence. Short duration of the study may not capture long-term effects.

Published in

Journal Reference

Publication details and source links for this paper.

Michal R, Orly B, Anastasia G, et al. Clinical effects of a personalized postprandial-targeting diet on glycemic control in newly diagnosed type 2 diabetes. BMC Medicine. 2022;20:56. doi:10.1186/s12916-022-02254-y

Main Effects

Average postprandial glucose response decreased by 19.8 mg/dl × h, p < 0.001.

Mean glucose decreased by 7.8 mg/dl, p < 0.001.

HbA1c decreased by 0.39%, p < 0.001.

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Mediterranean diet, Microbiome-guided personalized nutrition and Blood glucose, Diabetes remission, Fasting Plasma Glucose (FPG), and 5 more.

Primary intervention

Mediterranean diet

Primary outcomes

  • Blood glucose
  • Diabetes remission
  • Fasting Plasma Glucose (FPG)

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

16
Evidence pairs
16
Relationships
4
Evidence topics
contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 68

4

Related topics

16

Evidence pairs

1485

Related studies

High relevance in at least one topic

Why it is useful

  • Contributes to 16 evidence relationships
  • Includes primary outcome data
  • Linked to 4 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Add related evidence to your Evidence Tracker

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Primary evidence

Evidence topic

Dietary Patterns

matched_intervention_and_outcome

Related evidence

Evidence topic

Cardiometabolic Risk

Save evidence

Core evidence

Study findings

The primary outcomes reported in this study.

Blood glucose

Mediterranean diet → Blood glucose

Mediterranean diet → Blood glucose

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Diabetes remission

Mediterranean diet → Diabetes remission

Mediterranean diet → Diabetes remission

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Fasting Plasma Glucose (FPG)

Mediterranean diet → Fasting Plasma Glucose (FPG)

Mediterranean diet → Fasting Plasma Glucose (FPG)

Evidence Intelligence™
EvidenceScore™
Strong
Score 79 · Based on 4 studies
ImpactScore™
75
Positive
ConsistencyScore™
35
mixed
Supporting studies: Based on 4 studies
Add to Evidence Tracker

Fructosamine

Mediterranean diet → Fructosamine

Mediterranean diet → Fructosamine

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Glucose iAUC (OGTT)

Mediterranean diet → Glucose iAUC (OGTT)

Mediterranean diet → Glucose iAUC (OGTT)

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

HbA1c

Mediterranean diet → HbA1c

Mediterranean diet → HbA1c

Evidence Intelligence™
EvidenceScore™
85
Strong
ImpactScore™
71
Positive
ConsistencyScore™
57
generally_consistent
Supporting studies: Based on 7 studies
Add to Evidence Tracker

Mean glucose levels measured during the intervention

Mediterranean diet → Mean glucose levels measured during the intervention

Mediterranean diet → Mean glucose levels measured during the intervention

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Triglycerides

Mediterranean diet → Triglycerides

Mediterranean diet → Triglycerides

Evidence Intelligence™
EvidenceScore™
Moderate
Score 69 · Based on 2 studies
ImpactScore™
75
Positive
ConsistencyScore™
35
mixed
Supporting studies: Based on 2 studies
Add to Evidence Tracker

Blood glucose

Microbiome-guided personalized nutrition → Blood glucose

Microbiome-guided personalized nutrition → Blood glucose

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Diabetes remission

Microbiome-guided personalized nutrition → Diabetes remission

Microbiome-guided personalized nutrition → Diabetes remission

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
50
Neutral
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Fasting Plasma Glucose (FPG)

Microbiome-guided personalized nutrition → Fasting Plasma Glucose (FPG)

Microbiome-guided personalized nutrition → Fasting Plasma Glucose (FPG)

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Fructosamine

Microbiome-guided personalized nutrition → Fructosamine

Microbiome-guided personalized nutrition → Fructosamine

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Glucose iAUC (OGTT)

Microbiome-guided personalized nutrition → Glucose iAUC (OGTT)

Microbiome-guided personalized nutrition → Glucose iAUC (OGTT)

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

HbA1c

Microbiome-guided personalized nutrition → HbA1c

Microbiome-guided personalized nutrition → HbA1c

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Mean glucose levels measured during the intervention

Microbiome-guided personalized nutrition → Mean glucose levels measured during the intervention

Microbiome-guided personalized nutrition → Mean glucose levels measured during the intervention

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Triglycerides

Microbiome-guided personalized nutrition → Triglycerides

Microbiome-guided personalized nutrition → Triglycerides

Evidence Intelligence™
EvidenceScore™
Emerging
Score 59 · Based on 1 study
ImpactScore™
100
Very Positive
ConsistencyScore™
unclear
Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence Tracker

Evidence Library

Build your evidence library

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evidence suggest

Evidence Suggest

  • Personalized diet reduced average postprandial glucose response significantly.
  • Mean glucose levels decreased notably, indicating better control.
  • HbA1c levels showed significant reduction, reflecting improved long-term glucose management.
who this applies

Who this applies to

  • Adults with newly diagnosed type 2 diabetes.
  • Individuals seeking dietary interventions for glycemic control.
keep in mind

Keep in Mind

  • Results may not apply to all demographics outside the study population.
  • Further research is needed to confirm long-term effectiveness.
  • Dietary adherence may vary among individuals, affecting outcomes.
between the lines

Between the Lines

  • Limited generalizability due to specific population characteristics.
  • Potential biases in self-reported dietary adherence.
  • Short duration of the study may not capture long-term effects.

Evidence Library

Build your evidence library

Save research, organize studies, and quickly find important evidence again.

Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Mediterranean diet and HbA1c, Mediterranean diet and Fasting Glucose.

Related evidence relationships

Explore in Evidence Explorer

This study contributes to the evidence on the following intervention-outcome relationships.

Questions answered by this study

Generated from the study's connected evidence using Evidence Intelligence™.

Does Mediterranean diet improve HbA1c?

Strong Evidence

Mediterranean diet may improve HbA1c.

ConsistencyScore™: Results are generally consistent across studies.

Ranked evidence signals

  1. 1

    HbA1c

    EvidenceScore™ Strong | EvidenceScore™ 84.9 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Aug 2026

Does Mediterranean diet improve fasting plasma glucose (fpg)?

Strong Evidence

Mediterranean diet may improve Fasting Plasma Glucose (FPG).

ConsistencyScore™: Results are mixed and should be interpreted cautiously.

Evidence caveat: The available evidence reports mixed findings.

Ranked evidence signals

  1. 1

    Fasting Plasma Glucose (FPG)

    EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Mixed | 1 study

Why this answer: This answer is cautious because the available studies report mixed findings.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Aug 2026

Does Mediterranean diet improve triglycerides?

Moderate Evidence

Mediterranean diet may improve Triglycerides.

ConsistencyScore™: Results are mixed and should be interpreted cautiously.

Evidence caveat: The available evidence reports mixed findings.

Ranked evidence signals

  1. 1

    Triglycerides

    EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study

Why this answer: This answer is cautious because the available studies report mixed findings.

Limitations

  • Only one supporting study is available.
  • Population details are unavailable.
1 supporting studyUpdated: Aug 2026

Does Mediterranean diet improve blood glucose?

Emerging Evidence

Mediterranean diet appears to improve Blood glucose.

ConsistencyScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

  1. 1

    Blood glucose

    EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

  • Only one supporting study is available.
  • Consistency cannot yet be determined.
  • Population details are unavailable.
1 supporting studyUpdated: Aug 2026
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