Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
PRIME2 intervention improves weight loss in Latinx adults with prediabetes
Last updated September 3, 2026
Key finding
PRIME2 participants demonstrated significantly greater 3-month weight loss relative to usual care (−3.7 lbs, p = 0.02).
The PRIME2 trial evaluated a behavioral intervention for Latinx adults with prediabetes, finding significant weight loss compared to usual care.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
The PRIME2 trial evaluated a behavioral intervention for Latinx adults with prediabetes, finding significant weight loss compared to usual care.
Clinical relevance
Weight management is crucial for individuals with prediabetes, as it can prevent the progression to type 2 diabetes. The significant weight loss observed in participants receiving the PRIME2 intervention suggests that this approach could be an effective strategy for improving health outcomes in this high-risk population.
Keep in mind
The study had a small sample size, limiting generalizability. No long-term follow-up data were collected to assess sustained effects. The trial did not measure other potential confounding factors.
Published in
Journal Reference
Publication details and source links for this paper.
Maria CV, Joshua BK, Azucena L, Arturo C, Dyanna LG, Matthew JO. Pilot randomized controlled trial of the Promotora Intervention for Metabolic and Mental Health (PRIME2) among Latinx adults with prediabetes. Scientific Reports. 2024;14:31988. doi:10.1038/s41598-024-83482-5
Main Effects
PRIME2 participants demonstrated significantly greater 3-month weight loss relative to usual care (−3.7 lbs, p = 0.02).
No significant differences in perceived stress were observed between the two groups.
There were no significant differences in Hemoglobin A1C levels, blood pressure, or Beck depression scores.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to PRIME2 intervention and Body weight, Depression score, Diastolic blood pressure, and 3 more.
This study contributes evidence to
Primary intervention
PRIME2 intervention
Primary outcomes
- Body weight
- Depression score
- Diastolic blood pressure
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
4
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
4
Related topics
6
Evidence pairs
994
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 4 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Blood Pressure
matched_outcome
Related evidence
Evidence topic
Mental Health
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerDiastolic blood pressure
PRIME2 intervention → Diastolic blood pressure
PRIME2 intervention → Diastolic blood pressure
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerReduction in Hemoglobin A1C levels
PRIME2 intervention → Reduction in Hemoglobin A1C levels
PRIME2 intervention → Reduction in Hemoglobin A1C levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerSystolic blood pressure
PRIME2 intervention → Systolic blood pressure
PRIME2 intervention → Systolic blood pressure
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
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Evidence Suggest
- PRIME2 intervention participants lost an average of 3.7 lbs over 3 months.
- No significant changes in blood pressure or depression scores were found.
- Perceived stress levels were similar across both intervention and control groups.
Who this applies to
- Latinx adults aged 18-65 with prediabetes.
- Individuals seeking behavioral interventions for weight management.
Keep in Mind
- Results may not be applicable to non-Latinx populations.
- The study focused on short-term outcomes; long-term effects are unknown.
- Further research is needed to explore additional health benefits.
Between the Lines
- The study had a small sample size, limiting generalizability.
- No long-term follow-up data were collected to assess sustained effects.
- The trial did not measure other potential confounding factors.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on PRIME2 intervention and Body Weight, PRIME2 intervention and Mental Health.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
PRIME2 intervention → Body Weight
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceBehavioral & Lifestyle
PRIME2 intervention → Mental Health
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceBehavioral & Lifestyle
PRIME2 intervention → Blood Pressure
Behavioral & Lifestyle
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Blood Pressure Evidence Hub
All studies measuring Blood Pressure
1 studies
outcome_hubMeasures Blood Pressure as a key outcome.
Body Weight Evidence Hub
All studies measuring Body Weight
1 studies
outcome_hubMeasures Body Weight as a key outcome.
Mental Health Evidence Hub
All studies measuring Mental Health
1 studies
outcome_hubMeasures Mental Health as a key outcome.
PRIME2 intervention Evidence Hub
All studies on PRIME2 intervention
1 studies
intervention_hubContributes to PRIME2 intervention evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on PRIME2 intervention and Body weight
Intervention: PRIME2 interventionOutcome: Body weight
1 results
All studies on PRIME2 intervention and Depression score
Intervention: PRIME2 interventionOutcome: Depression score
1 results
All studies on PRIME2 intervention
Intervention: PRIME2 intervention
1 results
All studies measuring Body weight
Outcome: Body weight
1 results
All studies measuring Depression score
Outcome: Depression score
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does PRIME2 intervention affect body weight?
Emerging Evidence
PRIME2 intervention appears to affect body weight.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does PRIME2 intervention improve depression score?
Emerging Evidence
Current evidence does not show a clear benefit of PRIME2 intervention for depression score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Depression score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does PRIME2 intervention improve diastolic blood pressure?
Emerging Evidence
Current evidence does not show a clear benefit of PRIME2 intervention for diastolic blood pressure.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Diastolic blood pressure
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
What evidence is available on PRIME2 intervention and reduction in hemoglobin a1c levels?
Emerging Evidence
Current evidence does not show a clear reduction in reduction in hemoglobin a1c levels with PRIME2 intervention.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Reduction in Hemoglobin A1C levels
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
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