Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Quercetin supplementation improves health outcomes in type 2 diabetes patients
Last updated September 3, 2026
Key finding
HbA1c decreased by 4.0% compared to 0.1% in the control group (p = 0.011).
This randomized controlled trial evaluated the effects of quercetin on patients with type 2 diabetes receiving non-insulin medications, finding significant improvements in several health outcomes.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This randomized controlled trial evaluated the effects of quercetin on patients with type 2 diabetes receiving non-insulin medications, finding significant improvements in several health outcomes.
Clinical relevance
These findings suggest that quercetin could be a valuable addition to the treatment regimen for patients with type 2 diabetes, potentially enhancing their overall health and well-being. Given the chronic nature of diabetes and its associated complications, effective adjunct therapies like quercetin could help improve patient outcomes and quality of life.
Keep in mind
The study's sample size may limit the generalizability of the findings. Only short-term effects were assessed; long-term benefits of quercetin remain unclear. The study did not include a diverse population, which may affect applicability to broader groups.
Published in
Journal Reference
Publication details and source links for this paper.
Aikaterini EM, Manolis L, Maria T, et al. The Clinical Usefulness of Quercetin in Patients with Type 2 Diabetes Mellitus Receiving Non-Insulin Medications: A Randomized Controlled Trial. Journal of Clinical Medicine. 2024;13(12):3504. doi:10.3390/jcm13123504
Main Effects
HbA1c decreased by 4.0% in the quercetin group compared to 0.1% in the control group (p = 0.011).
FEV1 increased by 5.6% in the quercetin group compared to a decrease of 1.5% in the control group (p = 0.002).
Systolic blood pressure decreased by 5.0% in the quercetin group compared to a decrease of 0.2% in the control group (p = 0.029).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Quercetin and Anxiety levels (SAST-10), Forced expiratory volume in the first second (FEV1), HbA1c, and 3 more.
This study contributes evidence to
Primary intervention
Quercetin
Primary outcomes
- Anxiety levels (SAST-10)
- Forced expiratory volume in the first second (FEV1)
- HbA1c
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
3
Related topics
6
Evidence pairs
738
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Blood Pressure
matched_outcome
Related evidence
Evidence topic
HbA1c Reduction
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Forced expiratory volume in the first second (FEV1)
Quercetin → Forced expiratory volume in the first second (FEV1)
Quercetin → Forced expiratory volume in the first second (FEV1)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Evidence Suggest
- Quercetin significantly reduced HbA1c by 4.0% (p = 0.011).
- Participants experienced an 11.6% increase in night-time sleep (p < 0.001).
- Anxiety levels decreased by 26.2% in the quercetin group (p < 0.001).
Who this applies to
- Adults diagnosed with type 2 diabetes mellitus.
- Patients currently receiving non-insulin diabetes medications.
Keep in Mind
- The findings are based on a specific population and may not apply to all diabetes patients.
- Further research is needed to confirm long-term effects and safety of quercetin.
- The study did not assess potential interactions with other diabetes medications.
Between the Lines
- The study's sample size may limit the generalizability of the findings.
- Only short-term effects were assessed; long-term benefits of quercetin remain unclear.
- The study did not include a diverse population, which may affect applicability to broader groups.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Quercetin and Anxiety levels (SAST-10), Quercetin and Forced expiratory volume in the first second (FEV1).
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Quercetin → Anxiety levels (SAST-10)
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Quercetin → Quality of Life Outcomes
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Anxiety levels (SAST-10) Evidence Hub
All studies measuring Anxiety levels (SAST-10)
1 studies
outcome_hubMeasures Anxiety levels (SAST-10) as a key outcome.
Forced expiratory volume in the first second (FEV1) Evidence Hub
All studies measuring Forced expiratory volume in the first second (FEV1)
1 studies
outcome_hubMeasures Forced expiratory volume in the first second (FEV1) as a key outcome.
Quality of Life Outcomes Evidence Hub
All studies measuring Quality of Life Outcomes
1 studies
outcome_hubMeasures Quality of Life Outcomes as a key outcome.
Quercetin Evidence Hub
All studies on Quercetin
1 studies
intervention_hubContributes to Quercetin evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Quercetin and Anxiety levels (SAST-10)
Intervention: QuercetinOutcome: Anxiety levels (SAST-10)
1 results
All studies on Quercetin and Forced expiratory volume in the first second (FEV1)
Intervention: QuercetinOutcome: Forced expiratory volume in the first second (FEV1)
1 results
All studies on Quercetin
Intervention: Quercetin
1 results
All studies measuring Anxiety levels (SAST-10)
Outcome: Anxiety levels (SAST-10)
1 results
All studies measuring Forced expiratory volume in the first second (FEV1)
Outcome: Forced expiratory volume in the first second (FEV1)
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Quercetin improve anxiety levels (SAST-10)?
Emerging Evidence
Quercetin appears to improve anxiety levels (SAST-10).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Anxiety levels (SAST-10)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Quercetin improve forced expiratory volume in the first second (FEV1)?
Emerging Evidence
Quercetin appears to improve forced expiratory volume in the first second (FEV1).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Forced expiratory volume in the first second (FEV1)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Quercetin lower HbA1c?
Emerging Evidence
Quercetin appears to lower HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Quercetin improve night-time sleep?
Emerging Evidence
Quercetin appears to improve night-time sleep.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Night-time sleep
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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