Last updated July 8, 2026
Key finding
Significant improvements were observed in lean mass (1.70 [0.749, 2.665] kg; P < 0.01)
This study evaluated the efficacy of Sarcomeal supplement and vitamin D3 on muscle parameters in diabetic sarcopenia patients, revealing significant improvements in lean body mass and lean mass index.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the efficacy of Sarcomeal supplement and vitamin D3 on muscle parameters in diabetic sarcopenia patients, revealing significant improvements in lean body mass and lean mass index.
These findings suggest that Sarcomeal supplementation, along with vitamin D3, could be an effective strategy to combat muscle loss in diabetic sarcopenia patients. Maintaining lean body mass is crucial for overall health and functional ability in this population, potentially improving quality of life and reducing healthcare costs associated with sarcopenia.
Differences in skeletal muscle mass index and handgrip strength were not statistically significant. The study did not assess long-term effects beyond the intervention period. Side effects reported may limit the generalizability of findings.
Published in
Publication details and source links for this paper.
Ramin AD, Narges ZB, Ramin H, Gita S. Efficacy of Sarcomeal Supplement and Vitamin D3 on Muscle Parameters in Diabetic Sarcopenia Patients. Aging Clinical and Experimental Research. 2025;37(1):81. doi:10.1007/s40520-025-02969-x
Lean body mass increased by 1.7 kg in the intervention group (p=0.01).
Lean mass index improved by 0.62 kg/m² in the intervention group (p=0.01).
Weight was maintained in the intervention group, contrasting with a weight loss of 1.87 kg in the control group (p=0.01).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Vitamin D supplementation and Blood parameters, Gastrointestinal disorders incidence, Handgrip Strength, and 2 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
5
Evidence pairs
399
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Vitamin D supplementation → Blood parameters
Vitamin D supplementation → Blood parameters
Vitamin D supplementation → Gastrointestinal disorders incidence
Vitamin D supplementation → Gastrointestinal disorders incidence
Vitamin D supplementation → Handgrip Strength
Vitamin D supplementation → Handgrip Strength
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Body Composition, Vitamin D supplementation and Blood parameters.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Supplements
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Body Composition
Measures Body Composition as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
All studies measuring Blood parameters
Measures Blood parameters as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
Latest published studies
Published within the last 2 years.
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2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation may improve Lean body mass.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Lean body mass
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Vitamin D supplementation appears to improve Weight change.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Weight change
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Vitamin D supplementation for Blood parameters.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Blood parameters
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Vitamin D supplementation for Gastrointestinal disorders incidence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Gastrointestinal disorders incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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