NoneNo Change
Blood parameters
Vitamin D supplementation → Blood parameters
Vitamin D supplementation → Blood parameters
Evidence profile
NoneNo ChangeMetabolic Health
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Research Summary
Analyzed using Evidence Intelligence™
Sarcomeal Supplement Improves Muscle Mass in Diabetic Patients
Key finding
Significant improvements were observed in lean mass (1.70 [0.749, 2.665] kg; P < 0.01)
This study evaluated the efficacy of Sarcomeal supplement and vitamin D3 on muscle parameters in diabetic sarcopenia patients, revealing significant improvements in lean body mass and lean mass index.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Some Concerns bias
Last updated July 8, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Sarcomeal sachet plus vitamin D3
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Skeletal muscle mass index
Comparator
Standard care recommendations
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study evaluated the efficacy of Sarcomeal supplement and vitamin D3 on muscle parameters in diabetic sarcopenia patients, revealing significant improvements in lean body mass and lean mass index.
Clinical relevance
These findings suggest that Sarcomeal supplementation, along with vitamin D3, could be an effective strategy to combat muscle loss in diabetic sarcopenia patients. Maintaining lean body mass is crucial for overall health and functional ability in this population, potentially improving quality of life and reducing healthcare costs associated with sarcopenia.
Keep in mind
Differences in skeletal muscle mass index and handgrip strength were not statistically significant. The study did not assess long-term effects beyond the intervention period. Side effects reported may limit the generalizability of findings.
Published in
Journal Reference
Publication details and source links for this paper.
Ramin AD, Narges ZB, Ramin H, Gita S. Efficacy of Sarcomeal Supplement and Vitamin D3 on Muscle Parameters in Diabetic Sarcopenia Patients. Aging Clinical and Experimental Research. 2025;37(1):81. doi:10.1007/s40520-025-02969-x
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Main Effects
Lean body mass increased by 1.7 kg in the intervention group (p=0.01).
Lean mass index improved by 0.62 kg/m² in the intervention group (p=0.01).
Weight was maintained in the intervention group, contrasting with a weight loss of 1.87 kg in the control group (p=0.01).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Vitamin D supplementation and Blood parameters, Gastrointestinal disorders incidence, Handgrip Strength, and 2 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
- Blood parameters
- Gastrointestinal disorders incidence
- Handgrip Strength
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
5
Evidence pairs
5
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 63
1
Related topics
5
Evidence pairs
88
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 5 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
Core evidence
Study findings
The primary outcomes reported in this study.
NoneNo Change
Gastrointestinal disorders incidence
Vitamin D supplementation → Gastrointestinal disorders incidence
Vitamin D supplementation → Gastrointestinal disorders incidence
Evidence profile
NoneNo ChangeSafety
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NoneNo Change
Handgrip Strength
Vitamin D supplementation → Handgrip Strength
Vitamin D supplementation → Handgrip Strength
Evidence profile
NoneNo ChangeMetabolic Health
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NoneNo Change
Lean body mass
Vitamin D supplementation → Lean body mass
Vitamin D supplementation → Lean body mass
Evidence profile
NoneNo ChangeWeight & Anthropometrics
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StrongNo Change
Weight change
Vitamin D supplementation → Weight change
Vitamin D supplementation → Weight change
Evidence profile
StrongNo ChangeWeight & Anthropometrics
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Create a free account to access effectiveness ratings, evidence strength and depth scores, consistency analysis, and direct links to all supporting studies.
Evidence Suggest
- Lean body mass improved significantly by 1.7 kg with Sarcomeal and vitamin D3.
- Lean mass index increased by 0.62 kg/m², indicating enhanced muscle quality.
- Control group experienced significant weight loss, highlighting the intervention's stabilizing effect.
Who this applies to
- Adults diagnosed with diabetic sarcopenia.
- Patients experiencing muscle loss due to diabetes.
- Individuals seeking nutritional interventions for muscle health.
Keep in Mind
- Results may not be applicable to non-diabetic populations.
- The study's short duration limits understanding of long-term benefits.
- Reported side effects could affect adherence to the intervention.
Between the Lines
- Differences in skeletal muscle mass index and handgrip strength were not statistically significant.
- The study did not assess long-term effects beyond the intervention period.
- Side effects reported may limit the generalizability of findings.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Body Weight, Vitamin D supplementation and Body Composition.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Composition Evidence Hub
All studies measuring Body Composition
2 studies
outcome_hubMeasures Body Composition as a key outcome.
Body Weight Evidence Hub
All studies measuring Body Weight
1 studies
outcome_hubMeasures Body Weight as a key outcome.
Vitamin D supplementation Evidence Hub
All studies on Vitamin D supplementation
1 studies
intervention_hubContributes to Vitamin D supplementation evidence base.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Vitamin D supplementation and Weight change
Intervention: Vitamin D supplementationOutcome: Weight change
1 results
All studies on Vitamin D supplementation and Lean body mass
Intervention: Vitamin D supplementationOutcome: Lean body mass
2 results
All studies on Vitamin D supplementation
Intervention: Vitamin D supplementation
1 results
All studies measuring Weight change
Outcome: Weight change
1 results
All studies measuring Lean body mass
Outcome: Lean body mass
2 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Vitamin D supplementation improve weight change?
Emerging Evidence
Vitamin D supplementation appears to improve Weight change.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Weight change
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Vitamin D supplementation affect lean body mass?
Emerging Evidence
Vitamin D supplementation may improve Lean body mass.
ConsensusScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Lean body mass
EvidenceScore™ Emerging | EvidenceScore™ 47.1 | moderate positive | ConsensusScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve blood parameters?
Limited Evidence
Current evidence does not show a clear benefit of Vitamin D supplementation for Blood parameters.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Blood parameters
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Vitamin D supplementation improve gastrointestinal disorders incidence?
Limited Evidence
Current evidence does not show a clear benefit of Vitamin D supplementation for Gastrointestinal disorders incidence.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Gastrointestinal disorders incidence
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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