Last updated June 19, 2026
Key finding
Vitamin D supplementation significantly increased serum 25(OH)D levels.
This study examined the effects of vitamin D supplementation on oxidative stress, inflammation, and pregnancy outcomes in women with gestational diabetes mellitus, finding significant changes in several biomarkers.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
Save research, organize studies, and quickly find important evidence again.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the effects of vitamin D supplementation on oxidative stress, inflammation, and pregnancy outcomes in women with gestational diabetes mellitus, finding significant changes in several biomarkers.
The findings suggest that vitamin D supplementation may play a role in managing oxidative stress and inflammation in pregnant women with gestational diabetes. This could lead to improved maternal health and potentially better pregnancy outcomes, although the lower neonatal birth weight raises concerns that need further investigation.
The effectiveness of vitamin D supplementation remains unclear for some outcomes. The study may have limited generalizability due to specific population characteristics. No significant differences were found in fasting glucose changes.
Published in
Publication details and source links for this paper.
Yifan L, Liying L, Jiani Y, Qin Y. Effects of Vitamin D Supplementation on Oxidative Stress, Inflammation, and Pregnancy Outcomes in Women with Gestational Diabetes Mellitus. Endocrine Connections. 2026;15(2):e250932. doi:10.1530/EC-25-0932
Vitamin D supplementation significantly increased serum 25(OH)D levels by 6.38 ng/mL (p=0.021).
Calcium levels increased by 0.86 mg/dL (p=0.001) with vitamin D supplementation.
Vitamin D supplementation decreased MDA levels by 0.89 μmol/L (p=0.003) and hs-CRP levels by 1.28 mg/L (p=0.019).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Vitamin D supplementation and C-reactive protein, Calcium, Fasting Plasma Glucose (FPG), and 5 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
4
Related topics
8
Evidence pairs
675
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.
Primary evidence
Evidence topic
matched_intervention_and_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Vitamin D supplementation → C-reactive protein
Vitamin D supplementation → C-reactive protein
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Vitamin D supplementation → Incidence of macrosomia
Vitamin D supplementation → Incidence of macrosomia
Vitamin D supplementation → Malondialdehyde (MDA)
Vitamin D supplementation → Malondialdehyde (MDA)
Vitamin D supplementation → Neonatal birth weight
Vitamin D supplementation → Neonatal birth weight
Vitamin D supplementation → Oxidative stress markers (GSH)
Vitamin D supplementation → Oxidative stress markers (GSH)
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Vitamin D supplementation → Serum 25-hydroxyvitamin D
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Adipokine and Angiogenic Markers, Vitamin D supplementation and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring Neonatal birth weight
Measures Neonatal birth weight as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
6 results
3 results
6 results
6 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation appears to improve Serum 25-hydroxyvitamin D.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Serum 25-hydroxyvitamin D
EvidenceScore™ Strong | EvidenceScore™ 80.4 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Vitamin D supplementation for Fasting Plasma Glucose (FPG).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation may improve Malondialdehyde (MDA).
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Strong | EvidenceScore™ 77.4 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation may improve C-reactive protein.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Follow the topics this study contributes to.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Focused on evidence, not advertising.
Your data is always protected.
New studies added every day.
