Last updated July 6, 2026
Key finding
MDA decreased significantly (p < 0.001)
This study investigated the effects of Vitamin C supplementation on oxidative stress markers in patients with type 2 diabetes, finding significant reductions in malondialdehyde and advanced glycation end products.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of Vitamin C supplementation on oxidative stress markers in patients with type 2 diabetes, finding significant reductions in malondialdehyde and advanced glycation end products.
Oxidative stress is linked to the complications of diabetes, and reducing its markers may help improve health outcomes for patients. The significant reductions in malondialdehyde and advanced glycation end products suggest that Vitamin C could be a valuable addition to diabetes management strategies.
The study did not assess long-term effects of Vitamin C supplementation. Sample size and demographic details were not specified, limiting generalizability. Other potential confounding factors were not controlled for.
Published in
Publication details and source links for this paper.
Soghra R, Firouzeh H, Reza K, et al. Vitamin C supplementation may reduce oxidative stress markers in patients with type 2 diabetes. Food Science & Nutrition. 2023;11(10):5967-5977. doi:10.1002/fsn3.3530
Malondialdehyde decreased significantly by -0.38 µmol/L (p < 0.001)
Advanced glycation end products decreased significantly by -5.16 % (p = 0.002)
No significant changes were observed for advanced oxidation protein products (p = 0.234)
Evidence network
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This study contributes evidence to Vitamin D supplementation and Advanced glycation end products (AGEs), Advanced oxidation protein products (AOPP), C-reactive protein, and 4 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
7
Evidence pairs
69
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Vitamin D supplementation → Advanced glycation end products (AGEs)
Vitamin D supplementation → Advanced glycation end products (AGEs)
Vitamin D supplementation → Advanced oxidation protein products (AOPP)
Vitamin D supplementation → Advanced oxidation protein products (AOPP)
Vitamin D supplementation → C-reactive protein
Vitamin D supplementation → C-reactive protein
Vitamin D supplementation → LDL cholesterol
Vitamin D supplementation → LDL cholesterol
Vitamin D supplementation → Malondialdehyde (MDA)
Vitamin D supplementation → Malondialdehyde (MDA)
Vitamin D supplementation → Plasma antioxidant capacity (FRAP)
Vitamin D supplementation → Plasma antioxidant capacity (FRAP)
Vitamin D supplementation → Tumor Necrosis Factor-alpha (TNF-α)
Vitamin D supplementation → Tumor Necrosis Factor-alpha (TNF-α)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Oxidative Stress Markers, Vitamin D supplementation and Inflammatory Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Oxidative Stress Markers
Measures Oxidative Stress Markers as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
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3 results
2 results
3 results
3 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation may improve Malondialdehyde (MDA).
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Strong | EvidenceScore™ 77.4 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation may improve C-reactive protein.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Current evidence does not show a clear benefit of Vitamin D supplementation for LDL cholesterol.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve Advanced glycation end products (AGEs).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Advanced glycation end products (AGEs)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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