Last updated June 17, 2026
Key finding
SEM reduced FPG.
This study evaluated the effects of semaglutide combined with insulin therapy on glycemic control and renal function in elderly patients with type 2 diabetes, finding significant improvements in several metabolic parameters.
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EvidenceScore™
Moderate
Study type
RCTs
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study evaluated the effects of semaglutide combined with insulin therapy on glycemic control and renal function in elderly patients with type 2 diabetes, finding significant improvements in several metabolic parameters.
This study highlights the potential of combining semaglutide with insulin therapy to enhance glycemic control and renal health in elderly patients, a demographic often at higher risk for diabetes complications. Improved management of blood sugar and kidney function can lead to better overall health outcomes and quality of life for these patients.
Limited sample size may affect generalizability. Short duration of follow-up may not capture long-term effects. Unmeasured confounders could influence outcomes.
Published in
Publication details and source links for this paper.
Lan Y, Ying Y, Suraiya S. Semaglutide Combined with Insulin Therapy Improves Glycemic Control and Renal Function in Elderly Patients with Type 2 Diabetes. International Journal of Endocrinology. 2026;2026:1543983. doi:10.1155/ije/1543983
Fasting Plasma Glucose decreased by 2.31 mmol/L (p=0.001)
HbA1c decreased by 1.66% (p=0.001)
24-Hour Urinary Protein decreased significantly (p=0.001)
Evidence network
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This study contributes evidence to Insulin therapy and 24-Hour Urinary Protein (24hUpr), Adverse events incidence, Endothelin-1 (ET-1), and 9 more.
This study contributes evidence to
Primary intervention
Insulin therapy
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
5
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12
Evidence pairs
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Insulin therapy → 24-Hour Urinary Protein (24hUpr)
Insulin therapy → 24-Hour Urinary Protein (24hUpr)
Insulin therapy → Adverse events incidence
Insulin therapy → Adverse events incidence
Insulin therapy → Estimated glomerular filtration rate
Insulin therapy → Estimated glomerular filtration rate
Insulin therapy → Fasting Plasma Glucose (FPG)
Insulin therapy → Fasting Plasma Glucose (FPG)
Insulin therapy → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Insulin therapy → Homeostatic Model Assessment of Beta-cell function (HOMA-β)
Insulin therapy → Urinary albumin-to-creatinine ratio
Insulin therapy → Urinary albumin-to-creatinine ratio
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Insulin Therapies and HbA1c, Insulin Therapies and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Insulin Therapies
Contributes to Insulin Therapies evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
Latest published studies
Published within the last 2 years.
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4 results
3 results
4 results
4 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Insulin Therapies may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 9 supporting studies with consistent results and a positive effect signal.
Limitations
Insulin Therapies appears to improve Insulin Resistance.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Insulin resistance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 7 supporting studies with consistent results and a positive effect signal.
Limitations
Insulin Therapies appears to improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 5 supporting studies with consistent results and a positive effect signal.
Limitations
Insulin Therapies appears to improve Postprandial and OGTT Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Glucose iAUC (OGTT)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
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