Dediabetes Logo
Questions
Published answers connected to evidence
Clinical Reference
Detailed intervention and outcome dossiers
Latest Research
Newest studies
About
How deDiabetes works
Settings
Login / Sign-up

Inflammatory and Vascular Markers in Diabetes Evidence

View Evidence Brief

Evidence on improving inflammatory and vascular markers

Evidence related to inflammatory, oxidative stress, endothelial, and vascular biomarkers measured in diabetes studies.

Build your Evidence Workspace

Save evidence about the topics you care about.

81
Studies
100
Evidence Pairs
Extensive Research
Evidence Base: 71/100

Evidence guide

What does the evidence say?

Does Vitamin D supplementation lower Inflammatory and Vascular Markers?

Vitamin D supplementation may lower Inflammatory and Vascular Markers.

View answer

Does Semaglutide lower C-reactive protein?

Semaglutide may lower C-reactive protein.

View answer

Does Exercise therapy lower Inflammatory and Vascular Markers?

Exercise therapy may lower Inflammatory and Vascular Markers.

View answer
Evidence Intelligence™

Evidence Summary

A structured summary of where the evidence is strongest, mixed, or still emerging.

Executive Summary

Inflammatory and Vascular Markers evidence appears to center on Curcumin supplementation.

Among 81 indexed studies and 63 interventions, the strongest signals are summarized from the available evidence. Exercise therapy has been studied often, while Curcumin supplementation appears to have stronger current evidence signals.

  • Evidence is consistently positive across multiple studies.
  • Some evidence is positive, but results are not consistent across all studies.
  • Early findings are encouraging, but stronger trials are needed.
Caution

This summary reflects the currently indexed evidence and should not be interpreted as treatment advice.

Key Finding

Evidence is consistently positive across multiple studies.

Interventions with strongest consistent evidence

Strongest consistent evidence

Why it matters

Consistent positive findings are easier to interpret than isolated or mixed results.

Interpretation

Curcumin supplementation appears to have a consistent beneficial signal in the indexed evidence.

View supporting studies
Evidence basis: 14 evidence pairs - 18 studies

Why this appears here

Strong evidenceConsistent resultsPositive effect signalMultiple RCTsGenerally consistentModerate evidence
Curcumin supplementation
3 studies
EvidenceScore™
79/100
ConsistencyScore™
100/100
Exercise therapy
5 studies
EvidenceScore™
79/100
ConsistencyScore™
56/100

Evidence Snapshot

81
Studies
63
Interventions
12
Outcomes
6
Strong evidence signals
1
Mixed evidence areas

Key Findings

Key patterns and insights identified across the research landscape

Moderate positive signal

Non-surgical periodontal treatment may improve C-reactive protein

Non-surgical periodontal treatment → C-reactive protein

Across 5 studies, Non-surgical periodontal treatment shows a moderate positive signal for C-reactive protein.

5 studies
EvidenceScore™: 81.13846153846154/100
View supporting studies
Strong positive signal

Exercise therapy shows strong evidence for improving Interleukin-6 (IL-6)

Exercise therapy → Interleukin-6 (IL-6)

Across 4 studies, Exercise therapy shows a consistent strong positive signal for Interleukin-6 (IL-6).

4 studies
EvidenceScore™: 79/100
View supporting studies
Moderate positive signal

Low-carbohydrate diet may improve Interleukin-6 (IL-6)

Low-carbohydrate diet → Interleukin-6 (IL-6)

Across 3 studies, Low-carbohydrate diet shows a moderate positive signal for Interleukin-6 (IL-6).

3 studies
EvidenceScore™: 79/100
View supporting studies
Strong positive signal

Curcumin supplementation shows strong evidence for improving Malondialdehyde (MDA)

Curcumin supplementation → Malondialdehyde (MDA)

Across 3 studies, Curcumin supplementation shows a consistent strong positive signal for Malondialdehyde (MDA).

3 studies
EvidenceScore™: 79/100
View supporting studies
Moderate positive signal

Exercise therapy may improve Tumor Necrosis Factor-alpha (TNF-α)

Exercise therapy → Tumor Necrosis Factor-alpha (TNF-α)

Across 3 studies, Exercise therapy shows a moderate positive signal for Tumor Necrosis Factor-alpha (TNF-α).

3 studies
EvidenceScore™: 79/100
View supporting studies

Supporting Evidence

Mixed or conflicting evidence

Some evidence is positive, but results are not consistent across all studies.

Areas where results are mixed

Why it matters

Mixed results suggest effects may depend on population, comparator, duration, or study design.

Interpretation

Exercise therapy is mixed in the currently indexed evidence.

Caution

Some supporting studies reported neutral, negative, or mixed findings.

Top entities

Exercise therapy
Non-surgical periodontal treatment
Exercise therapy
5 studies
EvidenceScore™
79/100
ConsistencyScore™
56/100

Why this appears here

Mixed Or Conflicting ResultsPositive Signal PresentNeutral Results PresentNegative Results Present
Evidence basis: 14 evidence pairs - 21 studies
View supporting studies
Promising but understudied

Early findings are encouraging, but stronger trials are needed.

Promising areas needing more evidence

Why it matters

Promising signals can guide further review, but they should not be treated as settled evidence.

Interpretation

Curcumin supplementation may have a beneficial signal, but the evidence base is still developing.

Caution

Current support is limited by study volume, RCT depth, or evidence strength.

Top entities

Curcumin supplementation
Low-carbohydrate diet
Curcumin supplementation
3 studies
EvidenceScore™
79/100
ConsistencyScore™
100/100

Why this appears here

Positive effect signalLimited study volume
Evidence basis: 11 evidence pairs - 16 studies
View supporting studies

Explore the Evidence

The sections below provide the complete evidence questions, supporting relationships, and underlying studies behind the summary above.

Questions Answered by the Evidence

Which interventions have evidence for inflammatory and vascular markers?

Vitamin D supplementation, Semaglutide, and Exercise therapy are among the most studied approaches for inflammatory and vascular markers.

Emerging Evidence · Consistency cannot yet be determined from the available evidence. · 81 studies · 80 RCTs

View top evidence signals ↓
  1. Non-surgical periodontal treatment · Strong · 5 studies
  2. Exercise therapy · Strong · 5 studies
  3. Curcumin supplementation · Strong · 3 studies

Vitamin D supplementation vs Semaglutide for inflammatory and vascular markers?

Vitamin D supplementation and Semaglutide have available evidence for inflammatory and vascular markers, but the comparison requires review of the underlying studies.

Strong Evidence · Results are generally consistent across studies. · 7 studies · 7 RCTs

View top evidence signals ↓
  1. Vitamin D supplementation · Strong · 4 studies
  2. Semaglutide · Strong · 3 studies
Browse all questions about Inflammatory and Vascular Markers

Overall Evidence Signals

Among 81 indexed studies and 63 interventions, the strongest signals are summarized from the available evidence. Exercise therapy has been studied often, while Curcumin supplementation appears to have stronger current evidence signals.

  • Evidence is consistently positive across multiple studies.
  • Some evidence is positive, but results are not consistent across all studies.
  • Early findings are encouraging, but stronger trials are needed.

Evidence Relationships

Explore the intervention-outcome relationships with the strongest supporting evidence for Inflammatory and Vascular Markers.

8 strong relationships, ranked by available evidence

Select any relationship to review its supporting studies.

Supporting Research

Selected studies that best represent the evidence behind this topic.

Click any study to view the full research summary, or click interventions and outcomes to filter Evidence Explorer.

Evidence Tracker

Track Inflammatory and Vascular Markers in Diabetes Evidence evidence

Save this evidence topic and revisit it as new studies are added.