Last updated July 18, 2026
Key finding
Vmax increased by 14% during hyperglycemia (p < 0.001).
This study investigated the effects of short-term hyperglycemia from insulin discontinuation on myocardial contractile function in type 2 diabetic patients, finding significant improvements in several cardiac metrics.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of short-term hyperglycemia from insulin discontinuation on myocardial contractile function in type 2 diabetic patients, finding significant improvements in several cardiac metrics.
These findings are clinically significant as they challenge the traditional view that hyperglycemia is solely detrimental. Understanding the potential short-term benefits of hyperglycemia could influence treatment strategies for type 2 diabetes, particularly in managing insulin therapy. This could lead to improved cardiac outcomes in patients who experience fluctuations in blood sugar levels.
The study's sample size and demographic diversity were not specified, limiting generalizability. The effects of longer-term hyperglycemia were not assessed, leaving questions about sustained impact. Potential confounding factors related to patient health status were not fully addressed.
Published in
Publication details and source links for this paper.
Roni N, Helene N, Ulla K, et al. Short-term hyperglycemia by insulin discontinuation increases myocardial contractile function in type 2 diabetic patients. PLoS ONE. 2013;8(1):e53247. doi:10.1371/journal.pone.0053247
Maximal global systolic tissue velocity (Vmax) increased by 14% during hyperglycemia (p < 0.001).
Maximal mitral annulus velocity (S'max) increased by 10% during hyperglycemia (p < 0.001).
6-minute hall walk distance improved by 7% during hyperglycemia (p = 0.02).
Evidence network
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This study contributes evidence to Hyperglycemia induced by insulin discontinuation and 6-minute walk distance, Catecholamine Levels in Normo- and Hyperglycemia, Global longitudinal strain, and 5 more.
This study contributes evidence to
Primary intervention
Hyperglycemia induced by insulin discontinuation
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
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Evidence network role
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1
Related topics
8
Evidence pairs
47
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Hyperglycemia induced by insulin discontinuation → 6-minute walk distance
Hyperglycemia induced by insulin discontinuation → 6-minute walk distance
Hyperglycemia induced by insulin discontinuation → Catecholamine Levels in Normo- and Hyperglycemia
Hyperglycemia induced by insulin discontinuation → Catecholamine Levels in Normo- and Hyperglycemia
Hyperglycemia induced by insulin discontinuation → Global longitudinal strain
Hyperglycemia induced by insulin discontinuation → Global longitudinal strain
Hyperglycemia induced by insulin discontinuation → Left ventricular ejection fraction (LVEF)
Hyperglycemia induced by insulin discontinuation → Left ventricular ejection fraction (LVEF)
Hyperglycemia induced by insulin discontinuation → Maximal global systolic tissue velocity (Vmax) during hyperglycemia
Hyperglycemia induced by insulin discontinuation → Maximal global systolic tissue velocity (Vmax) during hyperglycemia
Hyperglycemia induced by insulin discontinuation → Maximal mitral annulus velocity (S'max) during hyperglycemia
Hyperglycemia induced by insulin discontinuation → Maximal mitral annulus velocity (S'max) during hyperglycemia
Hyperglycemia induced by insulin discontinuation → Peak exercise capacity
Hyperglycemia induced by insulin discontinuation → Peak exercise capacity
Hyperglycemia induced by insulin discontinuation → Strain rate
Hyperglycemia induced by insulin discontinuation → Strain rate
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Hyperglycemia induced by insulin discontinuation and Cardiovascular Outcomes, Hyperglycemia induced by insulin discontinuation and Catecholamine Levels in Normo- and Hyperglycemia.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring Cardiovascular Outcomes
Measures Cardiovascular Outcomes as a key outcome.
All studies measuring Catecholamine Levels in Normo- and Hyperglycemia
Measures Catecholamine Levels in Normo- and Hyperglycemia as a key outcome.
All studies on Hyperglycemia induced by insulin discontinuation
Contributes to Hyperglycemia induced by insulin discontinuation evidence base.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Hyperglycemia induced by insulin discontinuation appears to improve 6-minute walk distance.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
6-minute walk distance
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Hyperglycemia induced by insulin discontinuation appears to improve Global longitudinal strain.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Global longitudinal strain
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Hyperglycemia induced by insulin discontinuation appears to improve Maximal global systolic tissue velocity (Vmax) during hyperglycemia.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Maximal global systolic tissue velocity (Vmax) during hyperglycemia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Hyperglycemia induced by insulin discontinuation appears to improve Maximal mitral annulus velocity (S'max) during hyperglycemia.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Maximal mitral annulus velocity (S'max) during hyperglycemia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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