Last updated August 25, 2026
Key finding
Fasting blood glucose decreased significantly from baseline.
This study evaluated the impact of structured exercise interventions on biochemical markers in sedentary prediabetic patients, finding significant reductions in fasting plasma glucose and HbA1c levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the impact of structured exercise interventions on biochemical markers in sedentary prediabetic patients, finding significant reductions in fasting plasma glucose and HbA1c levels.
These findings are clinically significant as they suggest that structured exercise interventions can be an effective strategy for managing prediabetes and potentially preventing the progression to type 2 diabetes. By improving key biochemical markers, such interventions may help reduce the risk of developing diabetes-related complications, thus enhancing patient outcomes and quality of life.
Limited sample size may affect generalizability. Short duration of the study may not capture long-term effects. Potential biases in self-reported exercise adherence.
Published in
Publication details and source links for this paper.
Sana H, Syed SUR, Saima R, et al. Impact of Structured Exercise Manual Interventions on Biochemical Markers in Sedentary Prediabetic Patients: A Randomized Controlled Trial. Medicina. 2025;61(2):190. doi:10.3390/medicina61020190
Fasting Plasma Glucose decreased by -12.82 mg/dL (p=0.001)
HbA1c decreased by -0.67% (p=0.001)
Triglycerides decreased by -0.25 mmol/L (p=0.001)
LDL cholesterol decreased by -19.31 mg/dL (p=0.001)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Control Group Usual Activity, Structured exercise manual with diet and education guidance, Unsupervised exercise manual intervention and Fasting Plasma Glucose (FPG), HDL cholesterol, HOMA-B, and 3 more.
This study contributes evidence to
Primary intervention
Control Group Usual Activity
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
18
Evidence pairs
777
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Control Group Usual Activity → Fasting Plasma Glucose (FPG)
Control Group Usual Activity → Fasting Plasma Glucose (FPG)
Control Group Usual Activity → HDL cholesterol
Control Group Usual Activity → HDL cholesterol
Control Group Usual Activity → LDL cholesterol
Control Group Usual Activity → LDL cholesterol
Control Group Usual Activity → Triglycerides
Control Group Usual Activity → Triglycerides
Structured exercise manual with diet and education guidance → Fasting Plasma Glucose (FPG)
Structured exercise manual with diet and education guidance → Fasting Plasma Glucose (FPG)
Structured exercise manual with diet and education guidance → HbA1c
Structured exercise manual with diet and education guidance → HbA1c
Structured exercise manual with diet and education guidance → HDL cholesterol
Structured exercise manual with diet and education guidance → HDL cholesterol
Structured exercise manual with diet and education guidance → HOMA-B
Structured exercise manual with diet and education guidance → HOMA-B
Structured exercise manual with diet and education guidance → LDL cholesterol
Structured exercise manual with diet and education guidance → LDL cholesterol
Structured exercise manual with diet and education guidance → Triglycerides
Structured exercise manual with diet and education guidance → Triglycerides
Unsupervised exercise manual intervention → Fasting Plasma Glucose (FPG)
Unsupervised exercise manual intervention → Fasting Plasma Glucose (FPG)
Unsupervised exercise manual intervention → HbA1c
Unsupervised exercise manual intervention → HbA1c
Unsupervised exercise manual intervention → HDL cholesterol
Unsupervised exercise manual intervention → HDL cholesterol
Unsupervised exercise manual intervention → HOMA-B
Unsupervised exercise manual intervention → HOMA-B
Unsupervised exercise manual intervention → LDL cholesterol
Unsupervised exercise manual intervention → LDL cholesterol
Unsupervised exercise manual intervention → Triglycerides
Unsupervised exercise manual intervention → Triglycerides
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Control Group Usual Activity and Fasting Glucose, Control Group Usual Activity and HbA1c.
This study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Physical Activity
Physical Activity
Curated evidence collections and hubs this study is part of.
All studies on Control Group Usual Activity
Contributes to Control Group Usual Activity evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Control Group Usual Activity for Fasting Plasma Glucose (FPG).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Structured exercise manual with diet and education guidance appears to improve Fasting Plasma Glucose (FPG).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Structured exercise manual with diet and education guidance appears to improve HDL cholesterol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Structured exercise manual with diet and education guidance appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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