Evidence Intelligence™
- EvidenceScore™
- 76
- Strong
- ImpactScore™
- 74
- Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 4 studies
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Switching to tirzepatide improves glycemic control and weight in type 2 diabetes
Last updated August 16, 2026
Key finding
HbA1c decreased by 1.44% (SE 0.07) for tirzepatide.
This study analyzed the effects of switching from dulaglutide to tirzepatide in adults with type 2 diabetes, showing greater reductions in HbA1c and body weight with tirzepatide.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
High Risk
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study analyzed the effects of switching from dulaglutide to tirzepatide in adults with type 2 diabetes, showing greater reductions in HbA1c and body weight with tirzepatide.
Clinical relevance
These findings are significant for clinicians managing type 2 diabetes, as they suggest that tirzepatide may offer superior glycemic control and weight management compared to dulaglutide. However, the increased gastrointestinal side effects must be considered when making treatment decisions.
Keep in mind
The study did not assess long-term effects beyond the trial duration. Sample size and demographic diversity may limit generalizability. Potential confounding factors were not fully controlled.
Published in
Journal Reference
Publication details and source links for this paper.
Rafael V, Ludger R, Palash S, Elisa GV, K KC, Anita YK. Switching from dulaglutide to tirzepatide in adults with type 2 diabetes: a subgroup analysis of SURPASS-SWITCH. BMJ Open Diabetes Research & Care. 2026;14(2):e005711. doi:10.1136/bmjdrc-2025-005711
Main Effects
Tirzepatide reduced HbA1c by 1.44% (SE 0.07) compared to 0.67% (SE 0.08) for dulaglutide.
Body weight decreased by 10.5 kg (SE 0.5) with tirzepatide versus 3.6 kg (SE 0.5) with dulaglutide.
Nausea incidence was 25.2% in the tirzepatide group compared to 18.9% in the dulaglutide group.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Dulaglutide, Tirzepatide and Body weight, Gastrointestinal disorders incidence, HbA1c, and 1 more.
This study contributes evidence to
Primary intervention
Dulaglutide
Primary outcomes
- Body weight
- Gastrointestinal disorders incidence
- HbA1c
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
8
Evidence pairs
8
Relationships
3
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 72
3
Related topics
8
Evidence pairs
1079
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 8 evidence relationships
- Includes primary outcome data
- Linked to 3 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
GLP-1 Receptor Agonists and HbA1c
Related evidence
Evidence relationship
GLP-1 Receptor Agonists and Body Weight
Save evidence
Evidence relationship
GLP-1 Receptor Agonists and Gastrointestinal Adverse Events
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Gastrointestinal disorders incidence
Dulaglutide → Gastrointestinal disorders incidence
Dulaglutide → Gastrointestinal disorders incidence
Evidence Intelligence™
- EvidenceScore™
- 76
- Strong
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 4 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 90
- Very Positive
- ConsistencyScore™
- 80
- consistent
Supporting studies: Based on 5 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 13 studies
Add to Evidence TrackerGastrointestinal disorders incidence
Tirzepatide → Gastrointestinal disorders incidence
Tirzepatide → Gastrointestinal disorders incidence
Evidence Intelligence™
- EvidenceScore™
- 77
- Strong
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 4 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 96
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 14 studies
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Tirzepatide led to a 1.44% decrease in HbA1c, significantly more than dulaglutide's 0.67%.
- Body weight decreased by 10.5 kg with tirzepatide compared to 3.6 kg with dulaglutide.
- Higher nausea rates were reported with tirzepatide (25.2%) compared to dulaglutide (18.9%).
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Patients currently using dulaglutide for diabetes management.
Keep in Mind
- Results may not apply to populations outside the study's demographic.
- Further research is needed to evaluate long-term safety and efficacy.
- Increased gastrointestinal side effects with tirzepatide should be monitored.
Between the Lines
- The study did not assess long-term effects beyond the trial duration.
- Sample size and demographic diversity may limit generalizability.
- Potential confounding factors were not fully controlled.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on GLP-1 Receptor Agonists and HbA1c, GLP-1 Receptor Agonists and HbA1c.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Medications
GLP-1 Receptor Agonists → HbA1c
Medications
Evidence Intelligence™
- EvidenceScore™
- 84
- Strong
- ImpactScore™
- 90
- Very Positive
- ConsistencyScore™
- 80
- consistent
Supporting studies: Based on 5 studies
View evidenceMedications
GLP-1 Receptor Agonists → HbA1c
Medications
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 96
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 14 studies
View evidenceMedications
GLP-1 Receptor Agonists → Body Weight
Medications
Evidence Intelligence™
- EvidenceScore™
- 83
- Strong
- ImpactScore™
- 92
- Very Positive
- ConsistencyScore™
- 100
- consistent
Supporting studies: Based on 13 studies
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Weight Evidence Hub
All studies measuring Body Weight
13 studies
outcome_hubMeasures Body Weight as a key outcome.
GLP-1 Receptor Agonists Evidence Hub
All studies on GLP-1 Receptor Agonists
5 studies
intervention_hubContributes to GLP-1 Receptor Agonists evidence base.
HbA1c Evidence Hub
All studies measuring HbA1c
5 studies
outcome_hubMeasures HbA1c as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Dulaglutide and HbA1c
Intervention: DulaglutideOutcome: HbA1c
5 results
All studies on Tirzepatide and HbA1c
Intervention: TirzepatideOutcome: HbA1c
14 results
All studies on Dulaglutide
Intervention: Dulaglutide
5 results
All studies on Tirzepatide
Intervention: Tirzepatide
14 results
All studies measuring HbA1c
Outcome: HbA1c
5 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Do GLP-1 Receptor Agonists lower HbA1c?
Strong Evidence
GLP-1 Receptor Agonists appear to lower HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 83.5 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 45 supporting studies with consistent results and a positive effect signal.
Do GLP-1 Receptor Agonists affect body weight?
Strong Evidence
GLP-1 Receptor Agonists may affect body weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Strong | EvidenceScore™ 82.9 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 43 supporting studies with consistent results and a positive effect signal.
Do GLP-1 Receptor Agonists affect gastrointestinal adverse events?
Strong Evidence
Current evidence does not show a clear effect of GLP-1 Receptor Agonists on gastrointestinal adverse events.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Gastrointestinal disorders incidence
EvidenceScore™ Strong | EvidenceScore™ 77.3 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 12 supporting studies and existing graph evidence signals.
Do GLP-1 Receptor Agonists affect hypoglycemia?
Strong Evidence
GLP-1 Receptor Agonists may affect hypoglycemia.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Severe hypoglycemia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 14 supporting studies with consistent results and a positive effect signal.
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Evidence topics
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Related research
Read related research summaries.
Tirzepatide may prevent type 2 diabetes in adults with obesity and prediabetesTirzepatide improves glycemic control in early-onset type 2 diabetesTirzepatide improves weight loss and cardiometabolic healthTirzepatide improves cardiometabolic health in obesity.Tirzepatide enhances insulin sensitivity in type 2 diabetes
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