Last updated July 18, 2026
Key finding
BMI decreased by 1.45 kg/m² (P = 0.005)
This study evaluated the effects of symbiotic capsules on glycaemic control and lipid profiles in patients with type 2 diabetes. The results indicated significant improvements in BMI, waist circumference, HDL, and fasting blood sugar levels.
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study evaluated the effects of symbiotic capsules on glycaemic control and lipid profiles in patients with type 2 diabetes. The results indicated significant improvements in BMI, waist circumference, HDL, and fasting blood sugar levels.
These findings are significant for managing type 2 diabetes, as improvements in BMI and waist circumference can reduce the risk of complications associated with diabetes. Enhanced lipid profiles and lower fasting blood sugar levels may contribute to better overall health outcomes for patients.
No significant change in glycated hemoglobin levels in the symbiotic group (P = 0.09) Limited generalizability due to specific population characteristics Short duration of the study may not capture long-term effects
Published in
Publication details and source links for this paper.
Sarah HAZ, Ban ASA, Zahraa HAZ, Khalid SF. Effects of Symbiotics on Glycaemic Control and Lipid Profiles in Patients with Type 2 Diabetes: A Double-Blind, Placebo-Controlled Trial. BMC Nutrition. 2024;10:165. doi:10.1186/s40795-024-00976-1
BMI decreased by 1.45 kg/m² (P = 0.005)
Waist circumference decreased by 1.76 cm (P = 0.023)
HDL increased by 3.74 mg/dL (P = 0.04)
Fasting blood sugar decreased by 15.34 mg/dL (P = 0.02)
Evidence network
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This study contributes evidence to Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide and BMI, Fasting blood sugar (FBS), HDL cholesterol, and 2 more.
This study contributes evidence to
Primary intervention
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
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Evidence network role
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Contributes evidence
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Primary evidence
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matched_outcome
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Core evidence
The primary outcomes reported in this study.
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → BMI
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → BMI
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → Fasting blood sugar (FBS)
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → Fasting blood sugar (FBS)
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → HbA1c
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → HbA1c
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → HDL cholesterol
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → HDL cholesterol
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → Waist circumference
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide → Waist circumference
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide and Body Mass Index, Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Body Mass Index
Measures Body Mass Index as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide
Contributes to Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide evidence base.
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1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide appears to improve BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide appears to improve Fasting blood sugar (FBS).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide appears to improve HDL cholesterol.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Symbiotic capsules containing 200 million colony-forming units plus fructo-oligosaccharide appears to improve Waist circumference.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Waist circumference
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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