Last updated August 22, 2026
Key finding
Testosterone treatment improved subjective social status.
This study evaluated the effects of testosterone treatment on quality of life in men at high risk for type 2 diabetes, finding improvements in subjective social status and sense of coherence.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
This study evaluated the effects of testosterone treatment on quality of life in men at high risk for type 2 diabetes, finding improvements in subjective social status and sense of coherence.
Understanding the impact of testosterone treatment on quality of life is crucial for clinicians managing men at risk for type 2 diabetes. Improvements in social status and coherence could lead to better mental health outcomes, potentially influencing treatment decisions and patient adherence.
Effectiveness of interventions remains unclear. Limited generalizability due to specific population characteristics. Potential confounding factors not controlled for in the study.
Published in
Publication details and source links for this paper.
Mathis G, Kristy PR, Mark D, et al. Testosterone Treatment and Quality of Life in Men at High Risk for Type 2 Diabetes. The Journal of Clinical Endocrinology and Metabolism. 2024;109(8):2019-2028. doi:10.1210/clinem/dgae085
Testosterone treatment improved subjective social status.
Testosterone treatment improved sense of coherence.
No significant differences in health-related quality of life measures between treatment arms.
Larger decreases in body weight were linked to improved mental quality of life.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Testosterone therapy and Improvement in Sense of Coherence, Improvement in subjective social status.
This study contributes evidence to
Primary intervention
Testosterone therapy
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
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0
Related topics
2
Evidence pairs
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Related studies
Core evidence
The primary outcomes reported in this study.
Testosterone therapy → Improvement in Sense of Coherence
Testosterone therapy → Improvement in Sense of Coherence
Testosterone therapy → Improvement in subjective social status
Testosterone therapy → Improvement in subjective social status
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Testosterone therapy and Improvement in Sense of Coherence, Testosterone therapy and Improvement in subjective social status.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Improvement in Sense of Coherence
Measures Improvement in Sense of Coherence as a key outcome.
All studies measuring Improvement in subjective social status
Measures Improvement in subjective social status as a key outcome.
All studies on Testosterone therapy
Contributes to Testosterone therapy evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Testosterone therapy appears to improve improvement in sense of coherence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Improvement in Sense of Coherence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Testosterone therapy appears to improve improvement in subjective social status.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Improvement in subjective social status
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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