Last updated September 10, 2026
Key finding
URLi significantly attenuated the reduction in glucose level compared with lispro during the 50% BRR (−26.8 ± 37 vs. −39.0 ± 39 mg/dL; P < 0.05).
Comparison of ultra-rapid lispro versus lispro during exercise with basal rate reductions in adults with type 1 diabetes.
Quick read
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EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
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Study focus
Comparison of ultra-rapid lispro versus lispro during exercise with basal rate reductions in adults with type 1 diabetes.
This study evaluated Comparison of ultra-rapid lispro versus lispro during exercise with basal rate reductions in adults with type 1 diabetes.
Limitations were not clearly described in the extracted text.
Published in
Publication details and source links for this paper.
Jennifer KL, Alexander A, Lauren VT, et al. Using Ultra-Rapid Lispro in Conventional CSII Pump Therapy Provides More Effective Basal Rate Reductions Prior to Exercise Compared with Lispro. Diabetes Care. 2026;49(7):1185-1193. doi:10.2337/dc25-2294
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Insulin Lispro, Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction and AUC during hypoglycemia (<70 mg/dL), glucose during exercise (100% BRR), glucose during exercise (50% BRR).
This study contributes evidence to
Primary intervention
Insulin Lispro
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
0
Related topics
6
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Insulin Lispro → AUC during hypoglycemia (<70 mg/dL)
Insulin Lispro → AUC during hypoglycemia (<70 mg/dL)
Insulin Lispro → glucose during exercise (100% BRR)
Insulin Lispro → glucose during exercise (100% BRR)
Insulin Lispro → glucose during exercise (50% BRR)
Insulin Lispro → glucose during exercise (50% BRR)
Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction → AUC during hypoglycemia (<70 mg/dL)
Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction → AUC during hypoglycemia (<70 mg/dL)
Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction → glucose during exercise (100% BRR)
Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction → glucose during exercise (100% BRR)
Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction → glucose during exercise (50% BRR)
Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction → glucose during exercise (50% BRR)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
Generated from the study's connected evidence using Evidence Intelligence™.
Insulin Lispro appears to improve glucose during exercise (100% brr).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
glucose during exercise (100% BRR)
EvidenceScore™ Unknown | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Insulin Lispro appears to improve glucose during exercise (50% brr).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
glucose during exercise (50% BRR)
EvidenceScore™ Unknown | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction appears to improve glucose during exercise (100% brr).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
glucose during exercise (100% BRR)
EvidenceScore™ Unknown | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Ultra-rapid lispro (URLi) - 50% Basal Rate Reduction appears to improve glucose during exercise (50% brr).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
glucose during exercise (50% BRR)
EvidenceScore™ Unknown | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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