Key finding
GSH levels increased from 2.72 ± 0.84 to 5.76 ± 3.19 μmol/ml after vitamin D supplementation.
This study investigated the effects of vitamin D supplementation on inflammatory factors in patients with type 2 diabetes, finding significant reductions in certain inflammatory markers.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Quick read
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Vitamin D supplementation, Regular treatment
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Serum GSH
Comparator
Standard treatment group
Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the effects of vitamin D supplementation on inflammatory factors in patients with type 2 diabetes, finding significant reductions in certain inflammatory markers.
Reducing inflammation is crucial for managing type 2 diabetes, as it can lead to better health outcomes and potentially lower the risk of complications. This study highlights the importance of vitamin D supplementation as a simple and potentially effective intervention for improving inflammatory profiles in diabetic patients.
Effectiveness of interventions remains unclear due to lack of p-values. The study may have limited generalizability due to specific population characteristics. Sample size and duration may affect the robustness of the findings.
Published in
Publication details and source links for this paper.
Jie‐Chao G, Yue‐Guan W, Wei‐Gang H, et al. Vitamin D Supplementation Reduces Inflammatory Factors in Patients with Type 2 Diabetes. Journal of Clinical Laboratory Analysis. 2022;36(5):e24430. doi:10.1002/jcla.24430
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Serum GSH levels increased by 3.04 μmol/ml after vitamin D supplementation.
Serum MCP-1 levels decreased by 25.69 pg/ml following vitamin D supplementation.
Serum IL-8 levels decreased by 22.16 pg/ml after vitamin D supplementation.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Standard type 2 diabetes medication treatment, unspecified, Vitamin D supplementation and Serum GSH levels in control group, Serum IL-8 levels in control group, Serum MCP-1 levels in control group, and 3 more.
This study contributes evidence to
Primary intervention
Standard type 2 diabetes medication treatment, unspecified
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
6
Evidence pairs
0
Related studies
Core evidence
The primary outcomes reported in this study.
Standard type 2 diabetes medication treatment, unspecified → Serum GSH levels in control group
Standard type 2 diabetes medication treatment, unspecified → Serum GSH levels in control group
Evidence profile
Standard type 2 diabetes medication treatment, unspecified → Serum IL-8 levels in control group
Standard type 2 diabetes medication treatment, unspecified → Serum IL-8 levels in control group
Evidence profile
Standard type 2 diabetes medication treatment, unspecified → Serum MCP-1 levels in control group
Standard type 2 diabetes medication treatment, unspecified → Serum MCP-1 levels in control group
Evidence profile
Vitamin D supplementation → Glutathione (GSH)
Vitamin D supplementation → Glutathione (GSH)
Evidence profile
Vitamin D supplementation → Serum IL-8
Vitamin D supplementation → Serum IL-8
Evidence profile
Vitamin D supplementation → Serum MCP-1
Vitamin D supplementation → Serum MCP-1
Evidence profile
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Glutathione (GSH), Vitamin D supplementation and Serum IL-8.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring Glutathione (GSH)
Measures Glutathione (GSH) as a key outcome.
All studies measuring Serum IL-8
Measures Serum IL-8 as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
Jump to pre-filtered views in the evidence archive.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation appears to improve Glutathione (GSH).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Glutathione (GSH)
EvidenceScore™ Emerging | EvidenceScore™ 53.0 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve Serum IL-8.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum IL-8
EvidenceScore™ Emerging | EvidenceScore™ 53.0 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve Serum MCP-1.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum MCP-1
EvidenceScore™ Emerging | EvidenceScore™ 53.0 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Standard type 2 diabetes medication treatment, unspecified for Serum GSH levels in control group.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Serum GSH levels in control group
EvidenceScore™ Limited | EvidenceScore™ 35.5 | neutral | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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