Última actualización 3 de julio de 2026
Key finding
HbA1c decreased significantly in the probiotic group (p=0.004).
This study investigated the effects of multispecies probiotic supplementation on glycemic control in individuals with type 2 diabetes over 24 weeks, finding significant reductions in HbA1c and increases in HDL-c.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This study investigated the effects of multispecies probiotic supplementation on glycemic control in individuals with type 2 diabetes over 24 weeks, finding significant reductions in HbA1c and increases in HDL-c.
These findings are clinically significant as they suggest that probiotic supplementation could be a beneficial adjunct therapy for managing glycemic control and improving lipid profiles in patients with type 2 diabetes. This could lead to better overall health outcomes and reduced risk of diabetes-related complications.
The study had a relatively small sample size, which may limit generalizability. The duration of the study was only 24 weeks, which may not capture long-term effects. Some outcomes showed trends but were not statistically significant, indicating uncertainty.
Published in
Publication details and source links for this paper.
Venkata C, Janardanan K, Kakithakara VL, Mohan R, Jayaprakash T, Grigorios P. The Impact of Multistrain Probiotic Supplementation on Glycemic Control in Type 2 Diabetes Mellitus: A 24-Week Randomized Controlled Trial. Life. 2024;14(11):1484. doi:10.3390/life14111484
HbA1c decreased significantly in the probiotic group (p=0.004)
HDL-c increased significantly in the probiotic group (p<0.001)
Total cholesterol showed no significant change (p=0.556)
Triglycerides showed no significant change (p=0.233)
Evidence network
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This study contributes evidence to Multispecies probiotic supplementation and Blood glucose, HDL cholesterol, HbA1c, and 4 more.
This study contributes evidence to
Primary intervention
Multispecies probiotic supplementation
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
7
Evidence pairs
335
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Core evidence
The primary outcomes reported in this study.
Multispecies probiotic supplementation → Blood glucose
Multispecies probiotic supplementation → Blood glucose
Multispecies probiotic supplementation → HDL cholesterol
Multispecies probiotic supplementation → HDL cholesterol
Multispecies probiotic supplementation → LDL cholesterol
Multispecies probiotic supplementation → LDL cholesterol
Multispecies probiotic supplementation → Postprandial blood glucose
Multispecies probiotic supplementation → Postprandial blood glucose
Multispecies probiotic supplementation → Total cholesterol
Multispecies probiotic supplementation → Total cholesterol
Multispecies probiotic supplementation → Triglycerides
Multispecies probiotic supplementation → Triglycerides
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12 tracked topics
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12 tracked topics
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48 studies
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and HbA1c, Probiotics and Synbiotics and Adipokine and Angiogenic Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
Latest published studies
Published within the last 2 years.
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3 results
2 results
3 results
3 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 11 supporting studies with generally consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 12 supporting studies with consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Total cholesterol
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 10 supporting studies with generally consistent results and a positive effect signal.
Limitations
Current evidence does not show a clear benefit of Probiotics and Synbiotics for Postprandial and OGTT Glucose.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Postprandial blood glucose
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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