Resumen de Investigación
Synbiotics improve health in elderly with diabetes
Moderate confidence
Low bias
Última actualización 15 de junio de 2026Conclusión Clave:
This study evaluated the effects of a multi-species synbiotic preparation on metabolic profiles in elderly patients with type 2 diabetes and high cardiovascular risk, finding significant reductions in weight, cholesterol, and glucose levels.
Estudio de un Vistazo
Participantes
Intervención
Synbiotic supplement containing multi-species probiotic and fructooligosaccharide
Resultados
Weight change, Body mass index (BMI) change, Body fat mass (BFM) change, Low-density lipoprotein cholesterol (LDL-C) change, Total cholesterol change, Vascular cell adhesion molecule 1 (VCAM-1) change, Fasting blood sugar (FBS), Homeostatic model assessment for insulin resistance (HOMA-IR) change
Financiamiento
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Efectos Principales
Weight decreased by -1.16 kg (p=0.001)
Total cholesterol decreased by -11.78 mg/dl (p=0.012)
Fasting plasma glucose decreased by -22.83 mg/dl (p=0.001)
Resumen de Evidencia
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Synchronous online type 1 diabetes psychoeducational program for school staff (Behavioral & Lifestyle) |  Body fat mass (BFM) change (Weight & Anthropometrics) | Decrease | Strong |
Synchronous online type 1 diabetes psychoeducational program for school staff (Behavioral & Lifestyle) | Body Mass Index (BMI) change (Weight & Anthropometrics) | Decrease | Strong |
Synchronous online type 1 diabetes psychoeducational program for school staff (Behavioral & Lifestyle) |  Fasting blood sugar (FBS) (Glycemic Control) | Decrease | Strong |
Synchronous online type 1 diabetes psychoeducational program for school staff (Behavioral & Lifestyle) |  Homeostatic model assessment for insulin resistance (HOMA-IR) change (Clinical Outcomes) | Decrease | Strong |
Synchronous online type 1 diabetes psychoeducational program for school staff (Behavioral & Lifestyle) |  LDL cholesterol (Metabolic Health) | Decrease | Strong |
Synchronous online type 1 diabetes psychoeducational program for school staff (Behavioral & Lifestyle) | Total cholesterol (Metabolic Health) | Decrease | Strong |
Synchronous online type 1 diabetes psychoeducational program for school staff (Behavioral & Lifestyle) | Vascular cell adhesion molecule 1 (VCAM-1) change (Clinical Outcomes) | Decrease | Strong |
Synchronous online type 1 diabetes psychoeducational program for school staff (Behavioral & Lifestyle) | Weight change (Weight & Anthropometrics) | Decrease | Strong |
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La Evidencia Sugiere
- Weight decreased by -1.16 kg, indicating effective weight management.
- Fasting plasma glucose decreased by -22.83 mg/dl, suggesting improved glycemic control.
- Total cholesterol decreased by -11.78 mg/dl, indicating cardiovascular risk reduction.
A quién se aplica
- Elderly patients aged 65 years and older
- Individuals diagnosed with type 2 diabetes
- Patients identified with high cardiovascular risk
Tener en Cuenta
- The study's findings are specific to elderly patients with diabetes.
- Further research is needed to confirm long-term benefits.
- Results may vary based on individual health conditions and lifestyle factors.
Entre Líneas
- Limited to a specific age group (≥65 years)
- Results may not be generalizable to younger populations
- Potential for unmeasured confounding factors
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Referencia de la Revista
Neda D, Elnaz N, Naser A, Shahrzad Y, Fariba E, Maryam H. A multi-species synbiotic preparation benefits elderly patients with T2DM and high cardiovascular risk. Nutrition & Diabetes. 2025. doi:10.1038/s41387-025-00408-4
Connected Evidence
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Relaciones de evidencia relacionadas
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Preguntas que esta evidencia ayuda a responder
Key clinical and research questions this study contributes to.
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