Última actualización 6 de julio de 2026
Key finding
Vitamin D supplementation had significant effects on maintaining bone health.
This study examined the effects of a 12-week intervention combining vitamin D supplementation and endurance exercise on bone health in patients with type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the effects of a 12-week intervention combining vitamin D supplementation and endurance exercise on bone health in patients with type 2 diabetes.
These findings highlight the importance of vitamin D and exercise in managing bone health for patients with type 2 diabetes, a population at risk for osteoporosis and related complications. Clinicians may consider these interventions to improve patient outcomes.
Effectiveness of interventions remains unclear due to limited data. Sample size and demographic diversity may limit generalizability. Potential confounding factors were not fully controlled.
Published in
Publication details and source links for this paper.
Xiaomin S, Wenjuan X, Zhongying L, et al. Effects of a 12-Week Vitamin D and Endurance Exercise Intervention on Bone Health in Patients with Type 2 Diabetes. Frontiers in Physiology. 2022;13:1003572. doi:10.3389/fphys.2022.1003572
Vitamin D supplementation increased bone mineral density by 0.05 g/cm² (p=0.01).
Vitamin D supplementation increased bone mineral content by 50 g (p=0.01).
Endurance exercise reduced body fat percentage by 1.5% (p=0.05).
Lean body mass increased by 2 kg (p=0.05).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Endurance exercise, Vitamin D supplementation and Body fat percentage reduction, Bone mineral content (BMC), Bone mineral density (BMD), and 1 more.
This study contributes evidence to
Primary intervention
Endurance exercise
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
183
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_outcome
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Core evidence
The primary outcomes reported in this study.
Endurance exercise → Body fat percentage reduction
Endurance exercise → Body fat percentage reduction
Vitamin D supplementation → Bone mineral content (BMC)
Vitamin D supplementation → Bone mineral content (BMC)
Vitamin D supplementation → Bone mineral density (BMD)
Vitamin D supplementation → Bone mineral density (BMD)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Body Composition, Endurance exercise and Body Composition.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Physical Activity
Curated evidence collections and hubs this study is part of.
All studies measuring Body Composition
Measures Body Composition as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
All studies on Endurance exercise
Contributes to Endurance exercise evidence base.
Jump to pre-filtered views in Evidence Explorer.
2 results
1 results
2 results
1 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation may improve Lean body mass.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Lean body mass
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Endurance exercise appears to improve Body fat percentage reduction.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Body fat percentage reduction
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve Bone mineral content (BMC).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Bone mineral content (BMC)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve Bone mineral density (BMD).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Bone mineral density (BMD)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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