Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 69
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
Add to Evidence TrackerResumen de Investigación
Analyzed using Evidence Intelligence™
Vitamin D may not delay diabetes in women with prediabetes
Última actualización 6 de julio de 2026
Key finding
There was no statistical significance in the incidence of diabetes in the control group as compared to the intervention group at the end of 2 years (P = 0.701).
This randomized controlled trial investigated the effects of vitamin D supplementation on women with prediabetes, finding no significant impact on diabetes incidence or related metabolic markers.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This randomized controlled trial investigated the effects of vitamin D supplementation on women with prediabetes, finding no significant impact on diabetes incidence or related metabolic markers.
Clinical relevance
These findings are important for clinicians and patients as they suggest that vitamin D supplementation may not be an effective strategy for preventing type 2 diabetes in women with prediabetes. Understanding the limitations of vitamin D in this context can help guide treatment decisions and patient education.
Keep in mind
The study may have limited generalizability due to the specific population studied. The duration of the study may not have been sufficient to observe long-term effects. Potential unmeasured confounding factors could have influenced the results.
Published in
Referencia de la Revista
Publication details and source links for this paper.
Puneet M, Shashi K, Anoop M, et al. Vitamin D Supplementation in Women with Prediabetes: A Randomized Controlled Trial. Journal of Family Medicine and Primary Care. 2021;10(8):3122-3129. doi:10.4103/jfmpc.jfmpc_311_21
Efectos Principales
No significant difference in the incidence of type 2 diabetes between the vitamin D and placebo groups (P = 0.701).
No statistically significant effect of vitamin D supplementation on serum HbA1c levels.
No statistically significant effect of vitamin D supplementation on serum cholesterol levels.
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Vitamin D supplementation and HbA1c, LDL cholesterol, type 2 diabetes mellitus.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
- HbA1c
- LDL cholesterol
- type 2 diabetes mellitus
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
3
Evidence pairs
3
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 65
2
Related topics
3
Evidence pairs
676
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 3 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
Supplements and Nutraceuticals
matched_intervention_and_outcome
Evidencia relacionada
Tema de evidencia
HbA1c Reduction
Guardar evidencia
Core evidence
Study findings
The primary outcomes reported in this study.
LDL cholesterol
Vitamin D supplementation → LDL cholesterol
Vitamin D supplementation → LDL cholesterol
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence Trackertype 2 diabetes mellitus
Vitamin D supplementation → type 2 diabetes mellitus
Vitamin D supplementation → type 2 diabetes mellitus
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
Add to Evidence TrackerEvidence Library
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La Evidencia Sugiere
- Vitamin D supplementation did not significantly lower diabetes incidence over two years.
- No impact on HbA1c levels was observed with vitamin D supplementation.
- Cholesterol levels remained unchanged despite vitamin D intake.
A quién se aplica
- Women diagnosed with prediabetes.
- Individuals at risk for developing type 2 diabetes.
Tener en Cuenta
- The findings may not apply to men or other age groups.
- Results are specific to the supplementation dosage and duration used in the study.
- Further research is needed to explore other potential benefits of vitamin D supplementation.
Entre Líneas
- The study may have limited generalizability due to the specific population studied.
- The duration of the study may not have been sufficient to observe long-term effects.
- Potential unmeasured confounding factors could have influenced the results.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and HbA1c, Vitamin D supplementation and Diabetes Incidence and Prevention.
Relaciones de evidencia relacionadas
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Vitamin D supplementation → HbA1c
Supplements
Evidence Intelligence™
- EvidenceScore™
- 82
- Strong
- ImpactScore™
- 69
- Positive
- ConsistencyScore™
- 60
- generally_consistent
Estudios de apoyo: Basado en 5 estudios
View evidenceSupplements
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
View evidenceSupplements
Evidence Intelligence™
- EvidenceScore™
- Moderate
- Score 69 · Based on 2 studies
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- 100
- consistent
Estudios de apoyo: Basado en 2 estudios
View evidenceIncluido en estas colecciones de evidencia
Curated evidence collections and hubs this study is part of.
HbA1c Evidence Hub
All studies measuring HbA1c
5 studies
outcome_hubMeasures HbA1c as a key outcome.
Vitamin D supplementation Evidence Hub
All studies on Vitamin D supplementation
5 studies
intervention_hubContributes to Vitamin D supplementation evidence base.
Adipokine and Angiogenic Markers Evidence Hub
All studies measuring Adipokine and Angiogenic Markers
2 studies
outcome_hubMeasures Adipokine and Angiogenic Markers as a key outcome.
Diabetes Incidence and Prevention Evidence Hub
All studies measuring Diabetes Incidence and Prevention
2 studies
outcome_hubMeasures Diabetes Incidence and Prevention as a key outcome.
Explora más en Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Vitamin D supplementation and HbA1c
Intervention: Vitamin D supplementationOutcome: HbA1c
5 results
All studies on Vitamin D supplementation and type 2 diabetes mellitus
Intervention: Vitamin D supplementationOutcome: type 2 diabetes mellitus
2 results
All studies on Vitamin D supplementation
Intervention: Vitamin D supplementation
5 results
All studies measuring HbA1c
Outcome: HbA1c
5 results
All studies measuring type 2 diabetes mellitus
Outcome: type 2 diabetes mellitus
2 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Vitamin D supplementation improve HbA1c?
Strong Evidence
Vitamin D supplementation may improve HbA1c.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
- 1
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 81.9 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve ldl cholesterol?
Moderate Evidence
Current evidence does not show a clear benefit of Vitamin D supplementation for LDL cholesterol.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
LDL cholesterol
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Does Vitamin D supplementation improve type 2 diabetes mellitus?
Moderate Evidence
Current evidence does not show a clear benefit of Vitamin D supplementation for type 2 diabetes mellitus.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
type 2 diabetes mellitus
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Population details are unavailable.
Next steps
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Evidence topics
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