Última actualización 8 de julio de 2026
Key finding
Following SRP and Vitamin D supplementation there was a measurably critical reduction in every one of the periodontal clinical indicators in both groups.
This study investigated the effects of Vitamin D3 supplementation alongside scaling and root planing in patients with Type 2 Diabetes Mellitus and periodontitis, finding significant improvements in periodontal health indicators.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of Vitamin D3 supplementation alongside scaling and root planing in patients with Type 2 Diabetes Mellitus and periodontitis, finding significant improvements in periodontal health indicators.
Improving periodontal health in patients with diabetes is crucial as it can influence overall health outcomes. This study suggests that adding Vitamin D3 supplementation to standard dental treatments could provide additional benefits, potentially reducing complications associated with both diabetes and periodontal disease.
Unclear effectiveness of Vitamin D3 supplementation Limited generalizability due to specific population characteristics Potential confounding factors not controlled for
Published in
Publication details and source links for this paper.
G R, Nubesh SK, Ramesh K, Indrajit K, Syed SHQ, Pavithra RS. Vitamin D3 Supplementation as an Adjunct to Scaling and Root Planing in Patients with Type 2 Diabetes Mellitus and Periodontitis. Journal of Pharmacy & Bioallied Sciences. 2023;15(Suppl 1):S346-S349. doi:10.4103/jpbs.jpbs_543_22
Plaque Index decreased by 11.6 units (p=0.001)
Gingival Bleeding Index decreased by 10 units (p=0.001)
Probing Pocket Depth decreased by 2.5 mm (p=0.001)
Clinical Attachment Level increased by 2 mm (p=0.001)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Vitamin D supplementation and Clinical attachment level, Fasting Plasma Glucose (FPG), Periodontal probing depth, and 3 more.
This study contributes evidence to
Primary intervention
Vitamin D supplementation
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
6
Evidence pairs
1311
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Evidencia principal
Tema de evidencia
matched_intervention_and_outcome
Evidencia relacionada
Tema de evidencia
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Core evidence
The primary outcomes reported in this study.
Vitamin D supplementation → Clinical attachment level
Vitamin D supplementation → Clinical attachment level
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Vitamin D supplementation → Fasting Plasma Glucose (FPG)
Vitamin D supplementation → Periodontal probing depth
Vitamin D supplementation → Periodontal probing depth
Vitamin D supplementation → Plaque Index (PI)
Vitamin D supplementation → Plaque Index (PI)
Vitamin D supplementation → Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
Vitamin D supplementation → Reduction in Gingival Bleeding Index following SRP and Vitamin D supplementation
Vitamin D supplementation → Serum concentration of vitamin D
Vitamin D supplementation → Serum concentration of vitamin D
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Vitamin D supplementation and Serum concentration of vitamin D, Vitamin D supplementation and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Serum concentration of vitamin D
Measures Serum concentration of vitamin D as a key outcome.
All studies on Vitamin D supplementation
Contributes to Vitamin D supplementation evidence base.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
Jump to pre-filtered views in Evidence Explorer.
4 results
3 results
4 results
4 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Vitamin D supplementation appears to improve serum concentration of vitamin d.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Serum concentration of vitamin D
EvidenceScore™ Strong | EvidenceScore™ 79.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Vitamin D supplementation for fasting plasma glucose (FPG).
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Strong | EvidenceScore™ 79.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve periodontal probing depth.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Periodontal probing depth
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Vitamin D supplementation appears to improve plaque index (PI).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Plaque Index (PI)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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