Sulfonylureas

View Evidence Brief

Evidence on outcomes studied for Sulfonylureas

Evidence related to Sulfonylureas.

Build your Evidence Workspace

Save evidence about the topics you care about.

Studies

Evidence Pairs

Moderate Evidence

Evidence Strength: 61/100

Evidence Intelligence™

Evidence Summary

A structured summary of where the evidence is strongest, mixed, or still emerging.

Executive Summary

Sulfonylureas evidence appears to center on HbA1c.

Among 11 indexed studies and 3 interventions, the strongest signals are summarized from the available evidence. HbA1c appears to be one of the clearer current evidence signals.

Evidence is consistently positive across multiple studies.
Some evidence is positive, but results are not consistent across all studies.
Early findings are encouraging, but stronger trials are needed.

Caution

This summary reflects the currently indexed evidence and should not be interpreted as treatment advice.

Key Finding

Evidence is consistently positive across multiple studies.

Interventions with strongest consistent evidence

Strongest consistent evidence

Why it matters

Consistent positive findings are easier to interpret than isolated or mixed results.

Interpretation

HbA1c appears to have a consistent beneficial signal in the indexed evidence.

View supporting studies

Evidence basis: 3 evidence pairs - 9 studies

Why this appears here

Strong evidenceConsistent resultsPositive effect signalMultiple RCTs

HbA1c

9 studies

EvidenceScore™

84/100

ConsistencyScore™

63/100

Evidence Snapshot

Studies

Interventions

Outcomes

Strong evidence signals

Mixed evidence areas

Key Findings

Key patterns and insights identified across the research landscape

Moderate positive signal

HbA1c

Across 5 studies, Glimepiride shows a consistent moderate positive signal for HbA1c.

5 studies

EvidenceScore™: 84.18461538461538/100

View supporting studies

Moderate positive signal

HbA1c

Across 3 studies, Gliclazide sustained release shows a moderate positive signal for HbA1c.

3 studies

EvidenceScore™: 79/100

View supporting studies

Moderate positive signal

Body weight

Across 2 studies, Gliclazide sustained release shows a moderate positive signal for Body weight.

2 studies

EvidenceScore™: 69/100

View supporting studies

Evidence signal

Body weight

Across 2 studies, Glimepiride shows a evidence signal for Body weight.

2 studies

EvidenceScore™: 69/100

View supporting studies

Neutral signal

Achievement of HbA1c ≤ 6.5%

Across 1 study, Glibenclamide shows a neutral signal for Achievement of HbA1c ≤ 6.5%.

1 studies

EvidenceScore™: 59/100

View supporting studies

Supporting Evidence

Mixed or conflicting evidence

Some evidence is positive, but results are not consistent across all studies.

Areas where results are mixed

Why it matters

Mixed results suggest effects may depend on population, comparator, duration, or study design.

Interpretation

HbA1c is mixed in the currently indexed evidence.

Caution

Some supporting studies reported neutral, negative, or mixed findings.

Top entities

HbA1c

Body weight

HbA1c

9 studies

EvidenceScore™

84/100

ConsistencyScore™

63/100

Why this appears here

Mixed Or Conflicting ResultsPositive Signal PresentNeutral Results PresentNegative Results Present

Evidence basis: 11 evidence pairs - 10 studies

View supporting studies

Promising but understudied

Early findings are encouraging, but stronger trials are needed.

Promising areas needing more evidence

Why it matters

Promising signals can guide further review, but they should not be treated as settled evidence.

Interpretation

Body weight may have a beneficial signal, but the evidence base is still developing.

Caution

Current support is limited by study volume, RCT depth, or evidence strength.

Top entities

Body weight

cholesterol esters

Body weight

4 studies

EvidenceScore™

69/100

ConsistencyScore™

39/100

Why this appears here

Positive effect signalLimited study volumeFew randomized trialsEmerging Or Limited Strength

Evidence basis: 7 evidence pairs - 7 studies

View supporting studies

Explore the Evidence

The sections below provide the complete evidence questions, supporting relationships, and underlying studies behind the summary above.

Questions Answered by the Evidence

What outcomes has Sulfonylureas been studied for?

HbA1c, Body weight, and Fasting Plasma Glucose (FPG) are among the most studied areas in relation to Sulfonylureas.

Emerging Evidence · Consistency cannot yet be determined from the available evidence. · 11 studies · 11 RCTs

View top evidence signals ↓

HbA1c · Strong · 9 studies
Body weight · Moderate · 4 studies
HDL cholesterol · Emerging · 2 studies

Do Sulfonylureas lower HbA1c?

Sulfonylureas may lower HbA1c.

Strong Evidence · Results are consistent across studies. · 9 studies · 9 RCTs

View top evidence signals ↓

HbA1c · Strong · 9 studies

Do Sulfonylureas affect body weight?

Sulfonylureas may affect body weight.

Moderate Evidence · Results are mixed and should be interpreted cautiously. · 4 studies · 4 RCTs

The evidence includes both beneficial and harmful or worsening results.

View top evidence signals ↓

Body weight · Moderate · 4 studies

Which outcomes have the strongest evidence for Sulfonylureas?

HbA1c, Body weight, and Fasting Plasma Glucose (FPG) have the strongest available evidence signals for Sulfonylureas.

Emerging Evidence · Consistency cannot yet be determined from the available evidence. · 10 studies · 10 RCTs

View top evidence signals ↓

HbA1c · Strong · 9 studies
Body weight · Moderate · 4 studies
HDL cholesterol · Emerging · 2 studies

Where does Sulfonylureas need more research?

Fasting Plasma Glucose (FPG), HDL cholesterol, and LDL cholesterol need more research in relation to Sulfonylureas.

Emerging Evidence · Consistency cannot yet be determined from the available evidence. · 4 studies · 4 RCTs

View top evidence signals ↓

HDL cholesterol · Emerging · 2 studies
LDL cholesterol · Emerging · 2 studies
Fasting Plasma Glucose (FPG) · Emerging · 2 studies

Browse all questions about Sulfonylureas

Overall Evidence Signals

Among 11 indexed studies and 3 interventions, the strongest signals are summarized from the available evidence. HbA1c appears to be one of the clearer current evidence signals.