Last updated August 29, 2026
Key finding
Participants with preimplantation HbA1c >7% achieved clinically meaningful and statistically significant mean reductions in HbA1c of 0.5% (P = 0.031).
This study investigated the long-term effects of 10 kHz spinal cord stimulation on glycemic control and weight in patients with painful diabetic neuropathy, finding significant improvements in HbA1c and body weight.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
High Risk
Save research, organize studies, and quickly find important evidence again.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the long-term effects of 10 kHz spinal cord stimulation on glycemic control and weight in patients with painful diabetic neuropathy, finding significant improvements in HbA1c and body weight.
These findings are clinically significant as they suggest that 10 kHz spinal cord stimulation could be an effective treatment option for patients with painful diabetic neuropathy, addressing both pain management and metabolic control. Improved glycemic control can reduce the risk of diabetes-related complications, while weight loss can enhance overall health and quality of life.
Limited generalizability due to specific population characteristics. Potential for unmeasured confounders affecting outcomes. Short follow-up duration may not capture long-term effects.
Published in
Publication details and source links for this paper.
David CK, Brian LL, Michael JJ, et al. Long-term Effects of 10 kHz Spinal Cord Stimulation on Glycemic Control and Weight in Patients with Painful Diabetic Neuropathy. Journal of Pain Research. 2024;17:3063-3074. doi:10.2147/JPR.S463383
Participants with HbA1c >7% achieved a mean reduction of 0.5% (P = 0.031).
Participants with HbA1c >8% achieved a mean reduction of 1.1% (P = 0.004).
A significant mean weight loss of 3.1 kg was observed (P = 0.003).
Mean VAS score for lower limb pain decreased from 7.5 cm to 1.5 cm (P < 0.001).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to 10 kHz Spinal Cord Stimulation (SCS) and Body weight, HbA1c, Mean Reduction in Pain Interference with Sleep, and 1 more.
This study contributes evidence to
Primary intervention
10 kHz Spinal Cord Stimulation (SCS)
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
2
Related topics
4
Evidence pairs
747
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.
Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
10 kHz Spinal Cord Stimulation (SCS) → Body weight
10 kHz Spinal Cord Stimulation (SCS) → Body weight
10 kHz Spinal Cord Stimulation (SCS) → Mean Reduction in Pain Interference with Sleep
10 kHz Spinal Cord Stimulation (SCS) → Mean Reduction in Pain Interference with Sleep
10 kHz Spinal Cord Stimulation (SCS) → Pain Intensity Score
10 kHz Spinal Cord Stimulation (SCS) → Pain Intensity Score
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on 10 kHz Spinal Cord Stimulation (SCS) and Pain Intensity Score, 10 kHz Spinal Cord Stimulation (SCS) and Body Weight.
This study contributes to the evidence on the following intervention-outcome relationships.
Devices & Technology
Devices & Technology
Curated evidence collections and hubs this study is part of.
All studies on 10 kHz Spinal Cord Stimulation (SCS)
Contributes to 10 kHz Spinal Cord Stimulation (SCS) evidence base.
All studies measuring Pain Intensity Score
Measures Pain Intensity Score as a key outcome.
All studies measuring Body Weight
Measures Body Weight as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
2 results
1 results
2 results
2 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
10 kHz Spinal Cord Stimulation (SCS) appears to improve Pain Intensity Score.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Pain Intensity Score
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
10 kHz Spinal Cord Stimulation (SCS) appears to improve Body weight.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
10 kHz Spinal Cord Stimulation (SCS) appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
10 kHz Spinal Cord Stimulation (SCS) appears to improve Mean Reduction in Pain Interference with Sleep.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Mean Reduction in Pain Interference with Sleep
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Follow the topics this study contributes to.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Focused on evidence, not advertising.
Your data is always protected.
New studies added every day.
