Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Akkermansia MucT May Improve Insulin Sensitivity
Last updated August 27, 2026
Key finding
3-months intake of pasteurized A. muciniphila MucT improved HOMA-based hepatic insulin sensitivity in prediabetic (12%; p = 0.05).
This study evaluated the effects of pasteurized Akkermansia muciniphila MucT on insulin sensitivity in adults with metabolic syndrome, finding improvements in certain subgroups.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
High Risk
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effects of pasteurized Akkermansia muciniphila MucT on insulin sensitivity in adults with metabolic syndrome, finding improvements in certain subgroups.
Clinical relevance
Improving insulin sensitivity is crucial for managing metabolic syndrome, which is linked to increased risk of diabetes and cardiovascular diseases. This study suggests that pasteurized Akkermansia muciniphila MucT could be a novel therapeutic approach for enhancing metabolic health, particularly in vulnerable populations.
Keep in mind
The primary endpoint of whole-body insulin sensitivity showed no significant difference. Effectiveness of interventions remains unclear for several outcomes. Sample size and demographic diversity may limit generalizability.
Published in
Journal Reference
Publication details and source links for this paper.
Peter S, Anneleen S, Leen R, et al. Pasteurized Akkermansia muciniphila MucT Improves Insulin Sensitivity in Adults with Metabolic Syndrome. Gut Microbes. 2026;18(1):2690689. doi:10.1080/19490976.2026.2690689
Main Effects
HOMA-based hepatic insulin sensitivity improved by 12% in prediabetic and older subgroups (p = 0.05).
GLP-1 excursion increased significantly compared to placebo (p < 0.01).
Trunk fat decreased significantly (p < 0.05).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Akkermansia muciniphila and Body weight, Insulin sensitivity, Post-OGTT GLP-1 excursion, and 1 more.
This study contributes evidence to
Primary intervention
Akkermansia muciniphila
Primary outcomes
- Body weight
- Insulin sensitivity
- Post-OGTT GLP-1 excursion
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
4
Evidence pairs
4
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 63
1
Related topics
4
Evidence pairs
376
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 4 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Weight Loss
matched_outcome
Core evidence
Study findings
The primary outcomes reported in this study.
Insulin sensitivity
Akkermansia muciniphila → Insulin sensitivity
Akkermansia muciniphila → Insulin sensitivity
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerPost-OGTT GLP-1 excursion
Akkermansia muciniphila → Post-OGTT GLP-1 excursion
Akkermansia muciniphila → Post-OGTT GLP-1 excursion
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
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Evidence Suggest
- 12% improvement in hepatic insulin sensitivity in prediabetic individuals.
- Significant increase in GLP-1 levels post-OGTT (p < 0.01).
- Reduction in trunk fat (p < 0.05).
Who this applies to
- Adults with metabolic syndrome.
- Prediabetic individuals.
- Individuals aged 63 years or older.
Keep in Mind
- The study did not find significant changes in overall insulin sensitivity.
- Results may not apply to younger populations or those without metabolic syndrome.
- Further research is needed to confirm long-term effects and mechanisms.
Between the Lines
- The primary endpoint of whole-body insulin sensitivity showed no significant difference.
- Effectiveness of interventions remains unclear for several outcomes.
- Sample size and demographic diversity may limit generalizability.
Evidence Library
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Akkermansia muciniphila and Body Weight, Akkermansia muciniphila and Post-OGTT GLP-1 excursion.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Akkermansia muciniphila → Body Weight
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 50
- Neutral
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Akkermansia muciniphila Evidence Hub
All studies on Akkermansia muciniphila
1 studies
intervention_hubContributes to Akkermansia muciniphila evidence base.
Body Weight Evidence Hub
All studies measuring Body Weight
1 studies
outcome_hubMeasures Body Weight as a key outcome.
Post-OGTT GLP-1 excursion Evidence Hub
All studies measuring Post-OGTT GLP-1 excursion
1 studies
outcome_hubMeasures Post-OGTT GLP-1 excursion as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Akkermansia muciniphila and Body weight
Intervention: Akkermansia muciniphilaOutcome: Body weight
1 results
All studies on Akkermansia muciniphila and Post-OGTT GLP-1 excursion
Intervention: Akkermansia muciniphilaOutcome: Post-OGTT GLP-1 excursion
1 results
All studies on Akkermansia muciniphila
Intervention: Akkermansia muciniphila
1 results
All studies measuring Body weight
Outcome: Body weight
1 results
All studies measuring Post-OGTT GLP-1 excursion
Outcome: Post-OGTT GLP-1 excursion
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Akkermansia muciniphila improve post-ogtt glp-1 excursion?
Emerging Evidence
Akkermansia muciniphila appears to improve post-ogtt glp-1 excursion.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Post-OGTT GLP-1 excursion
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Akkermansia muciniphila improve trunk fat?
Emerging Evidence
Akkermansia muciniphila appears to improve trunk fat.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Trunk fat
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Akkermansia muciniphila affect body weight?
Emerging Evidence
Current evidence does not show a clear effect of Akkermansia muciniphila on body weight.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Does Akkermansia muciniphila improve insulin sensitivity?
Emerging Evidence
Current evidence does not show a clear benefit of Akkermansia muciniphila for insulin sensitivity.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Insulin sensitivity
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
Next steps
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