Last updated September 9, 2026
Key finding
Average scores decreased more rapidly in the case group than in the control group.
This study evaluated the effectiveness of topical aloe vera extract in improving the healing of diabetic foot ulcers compared to standard care.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study evaluated the effectiveness of topical aloe vera extract in improving the healing of diabetic foot ulcers compared to standard care.
Diabetic foot ulcers are a common and serious complication for individuals with diabetes, often leading to severe outcomes. The findings suggest that incorporating topical aloe vera extract into treatment protocols could enhance healing and reduce the burden of these ulcers, ultimately improving patient outcomes and quality of life.
The study did not specify the sample size, which may affect the generalizability of the results. The effectiveness of aloe vera was assessed only over a limited time frame. Potential confounding factors were not fully addressed.
Published in
Publication details and source links for this paper.
Alexander M, John RA, Sandhiya T, et al. Topical Aloe Vera Extract Significantly Improves Healing of Diabetic Foot Ulcers Compared to Standard Care. Cureus. 2025;17(7):e88956. doi:10.7759/cureus.88956
Average BWAT scores decreased more rapidly in the aloe vera group than in the control group.
On Day 14, the case group's average BWAT score was 31 ± 2.16 compared to 35 ± 2.61 in the control group.
On Day 28, the case group's average score was 19 ± 2.17, while the control group had 25 ± 2.17.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Topical aloe vera extract and High improvement in BWAT score, Wound healing rate measured by reduction in ulcer size, Wound severity measured by Bates-Jensen Wound Assessment Tool.
This study contributes evidence to
Primary intervention
Topical aloe vera extract
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Related topics
3
Evidence pairs
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Related studies
Core evidence
The primary outcomes reported in this study.
Topical aloe vera extract → High improvement in BWAT score
Topical aloe vera extract → High improvement in BWAT score
Topical aloe vera extract → Wound healing rate measured by reduction in ulcer size
Topical aloe vera extract → Wound healing rate measured by reduction in ulcer size
Topical aloe vera extract → Wound severity measured by Bates-Jensen Wound Assessment Tool
Topical aloe vera extract → Wound severity measured by Bates-Jensen Wound Assessment Tool
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Topical aloe vera extract and High improvement in BWAT score, Topical aloe vera extract and Wound healing rate measured by reduction in ulcer size.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring High improvement in BWAT score
Measures High improvement in BWAT score as a key outcome.
All studies on Topical aloe vera extract
Contributes to Topical aloe vera extract evidence base.
All studies measuring Wound healing rate measured by reduction in ulcer size
Measures Wound healing rate measured by reduction in ulcer size as a key outcome.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Topical aloe vera extract appears to improve high improvement in bwat score.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
High improvement in BWAT score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Topical aloe vera extract appears to improve wound severity measured by bates-jensen wound assessment tool.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Wound severity measured by Bates-Jensen Wound Assessment Tool
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear reduction in wound healing rate measured by reduction in ulcer size with Topical aloe vera extract.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Wound healing rate measured by reduction in ulcer size
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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