Last updated July 18, 2026
Key finding
Bates-Jensen scores decreased (22.3 ± 4.5 vs. 26.1 ± 4.9, p < 0.001, Cohen's d = 0.67)
Topical ozonated olive oil significantly improved wound healing and quality of life in diabetic foot ulcer patients compared to standard care.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
Topical ozonated olive oil significantly improved wound healing and quality of life in diabetic foot ulcer patients compared to standard care.
This study highlights the potential of topical ozonated olive oil as an effective treatment for diabetic foot ulcers, which are common complications in diabetes. Improved wound healing and quality of life can lead to better patient outcomes and reduced healthcare costs, making this treatment a valuable addition to standard care practices.
Limited sample size may affect generalizability Short follow-up period may not capture long-term effects No significant changes in inflammatory markers were observed
Published in
Publication details and source links for this paper.
Solmaz V, Masome R, Tayebeh SS, et al. Topical ozonated olive oil significantly enhances wound healing, quality of life, glycemic control, and reduces inflammation in DFU patients. Lipids in Health and Disease. 2025;24:291. doi:10.1186/s12944-025-02726-z
Wound severity decreased significantly (Bates-Jensen scores: 22.3 ± 4.5 vs. 26.1 ± 4.9, p < 0.001)
Quality of life improved (scores: 50.1 ± 9.5 vs. 57.8 ± 10.0, p < 0.001)
HbA1c levels reduced (7.1 ± 1.0% vs. 7.7 ± 1.1%, p = 0.005)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Standard care with capillary blood glucose monitoring, Topical ozonated olive oil and Quality of life, Wound severity measured by Bates-Jensen Wound Assessment Tool, C-reactive protein, and 5 more.
This study contributes evidence to
Primary intervention
Standard care with capillary blood glucose monitoring
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
10
Evidence pairs
613
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Related evidence
Evidence topic
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Core evidence
The primary outcomes reported in this study.
Standard care with capillary blood glucose monitoring → Quality of life
Standard care with capillary blood glucose monitoring → Quality of life
Standard care with capillary blood glucose monitoring → Wound severity measured by Bates-Jensen Wound Assessment Tool
Standard care with capillary blood glucose monitoring → Wound severity measured by Bates-Jensen Wound Assessment Tool
Topical ozonated olive oil → C-reactive protein
Topical ozonated olive oil → C-reactive protein
Topical ozonated olive oil → Fasting blood sugar (FBS)
Topical ozonated olive oil → Fasting blood sugar (FBS)
Topical ozonated olive oil → Interleukin-6 (IL-6)
Topical ozonated olive oil → Interleukin-6 (IL-6)
Topical ozonated olive oil → Postprandial blood glucose
Topical ozonated olive oil → Postprandial blood glucose
Topical ozonated olive oil → Quality of life
Topical ozonated olive oil → Quality of life
Topical ozonated olive oil → Tumor Necrosis Factor-alpha (TNF-α)
Topical ozonated olive oil → Tumor Necrosis Factor-alpha (TNF-α)
Topical ozonated olive oil → Wound severity measured by Bates-Jensen Wound Assessment Tool
Topical ozonated olive oil → Wound severity measured by Bates-Jensen Wound Assessment Tool
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Standard care with capillary blood glucose monitoring and HbA1c, Standard care with capillary blood glucose monitoring and Quality of Life Outcomes.
This study contributes to the evidence on the following intervention-outcome relationships.
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on Standard care with capillary blood glucose monitoring
Contributes to Standard care with capillary blood glucose monitoring evidence base.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
Latest published studies
Published within the last 2 years.
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3 results
2 results
3 results
3 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Current evidence does not show a clear benefit of Standard care with capillary blood glucose monitoring for Quality of life.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Quality of life
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Topical ozonated olive oil appears to improve C-reactive protein.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Topical ozonated olive oil appears to improve Fasting blood sugar (FBS).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Fasting blood sugar (FBS)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Topical ozonated olive oil appears to improve HbA1c.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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