Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Bariatric surgery improves type 2 diabetes remission through gut microbiota changes
Last updated July 15, 2026
Key finding
Participants who underwent RYGB lost more weight compared to those who underwent SG.
This study investigated the effects of bariatric surgery on gut microbiota and type 2 diabetes remission, finding that Roux-en-Y gastric bypass (RYGB) led to greater weight loss and higher diabetes remission rates compared to sleeve gastrectomy (SG).
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Extended (5–20+ y)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of bariatric surgery on gut microbiota and type 2 diabetes remission, finding that Roux-en-Y gastric bypass (RYGB) led to greater weight loss and higher diabetes remission rates compared to sleeve gastrectomy (SG).
Clinical relevance
These findings highlight the potential of Roux-en-Y gastric bypass as a more effective surgical intervention for patients with obesity and type 2 diabetes, suggesting that it may lead to better long-term health outcomes. Understanding the differential impacts of these surgical options can help clinicians make informed decisions when recommending treatments for patients struggling with obesity and diabetes.
Keep in mind
The study's sample size may limit the generalizability of the findings. Potential confounding variables were not fully controlled for in the analysis. The long-term effects beyond 12 months were not assessed.
Published in
Journal Reference
Publication details and source links for this paper.
Lisa MO, Heidi B, Rima MC, et al. Bariatric surgery alters gut microbiota and influences type 2 diabetes remission. Nature Metabolism. 2026;8(5):1212-1228. doi:10.1038/s42255-026-01525-9
Main Effects
RYGB resulted in a weight loss of -10.5 kg (p=0.001) compared to SG, which resulted in -8 kg (p=0.01).
Fasting plasma glucose decreased by -1.5 mmol/L (p=0.046) after RYGB, showing greater improvement than SG.
Diabetes remission was achieved in 74% of RYGB patients compared to 52% of SG patients (p=0.046).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Gastric bypass, Sleeve gastrectomy and Diabetes remission, Fasting Plasma Glucose (FPG), Insulin secretion levels after Roux-en-Y gastric bypass surgery, and 1 more.
This study contributes evidence to
Primary intervention
Gastric bypass
Primary outcomes
- Diabetes remission
- Fasting Plasma Glucose (FPG)
- Insulin secretion levels after Roux-en-Y gastric bypass surgery
Evidence topics
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
7
Evidence pairs
7
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 68
2
Related topics
7
Evidence pairs
244
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 7 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Bariatric Procedures and Fasting Glucose
Related evidence
Evidence topic
Glycemic Control
Save evidence
Evidence topic
Bariatric Procedures
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Fasting Plasma Glucose (FPG)
Gastric bypass → Fasting Plasma Glucose (FPG)
Gastric bypass → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerInsulin secretion levels after Roux-en-Y gastric bypass surgery
Gastric bypass → Insulin secretion levels after Roux-en-Y gastric bypass surgery
Gastric bypass → Insulin secretion levels after Roux-en-Y gastric bypass surgery
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerWeight loss of 10% or more at 52 weeks
Gastric bypass → Weight loss of 10% or more at 52 weeks
Gastric bypass → Weight loss of 10% or more at 52 weeks
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerFasting Plasma Glucose (FPG)
Sleeve gastrectomy → Fasting Plasma Glucose (FPG)
Sleeve gastrectomy → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerWeight loss of 10% or more at 52 weeks
Sleeve gastrectomy → Weight loss of 10% or more at 52 weeks
Sleeve gastrectomy → Weight loss of 10% or more at 52 weeks
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
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Evidence Suggest
- RYGB led to a significant weight loss of -10.5 kg compared to -8 kg for SG.
- Fasting plasma glucose improved more with RYGB, decreasing by -1.5 mmol/L.
- Diabetes remission rates were higher with RYGB at 74% versus 52% for SG.
Who this applies to
- Adults with obesity and type 2 diabetes.
- Patients considering bariatric surgery for weight management.
Keep in Mind
- Results may not be applicable to all demographic groups due to sample characteristics.
- The study focused on short-term outcomes; long-term effects remain uncertain.
- Variability in individual responses to surgery may affect outcomes.
Between the Lines
- The study's sample size may limit the generalizability of the findings.
- Potential confounding variables were not fully controlled for in the analysis.
- The long-term effects beyond 12 months were not assessed.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Bariatric Procedures and Diabetes remission, Bariatric Procedures and Fasting Glucose.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Procedures
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceProcedures
Bariatric Procedures → Fasting Glucose
Procedures
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceProcedures
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Bariatric Procedures Evidence Hub
All studies on Bariatric Procedures
1 studies
intervention_hubContributes to Bariatric Procedures evidence base.
Diabetes remission Evidence Hub
All studies measuring Diabetes remission
1 studies
outcome_hubMeasures Diabetes remission as a key outcome.
Fasting Glucose Evidence Hub
All studies measuring Fasting Glucose
1 studies
outcome_hubMeasures Fasting Glucose as a key outcome.
Weight loss of 10% or more at 52 weeks Evidence Hub
All studies measuring Weight loss of 10% or more at 52 weeks
1 studies
outcome_hubMeasures Weight loss of 10% or more at 52 weeks as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Gastric bypass and Diabetes remission
Intervention: Gastric bypassOutcome: Diabetes remission
1 results
All studies on Gastric bypass and Fasting Plasma Glucose (FPG)
Intervention: Gastric bypassOutcome: Fasting Plasma Glucose (FPG)
1 results
All studies on Gastric bypass
Intervention: Gastric bypass
1 results
All studies measuring Diabetes remission
Outcome: Diabetes remission
1 results
All studies measuring Fasting Plasma Glucose (FPG)
Outcome: Fasting Plasma Glucose (FPG)
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Bariatric Procedures improve fasting glucose?
Moderate Evidence
Bariatric Procedures appears to improve Fasting Glucose.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
- 1
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
- Only a small number of supporting studies are available.
- Population details are unavailable.
Does Gastric bypass improve diabetes remission?
Emerging Evidence
Gastric bypass appears to improve Diabetes remission.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Diabetes remission
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Gastric bypass improve insulin secretion levels after roux-en-y gastric bypass surgery?
Emerging Evidence
Gastric bypass appears to improve Insulin secretion levels after Roux-en-Y gastric bypass surgery.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Insulin secretion levels after Roux-en-Y gastric bypass surgery
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Gastric bypass affect weight loss of 10% or more at 52 weeks?
Emerging Evidence
Gastric bypass appears to improve Weight loss of 10% or more at 52 weeks.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Weight loss of 10% or more at 52 weeks
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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