Last updated July 17, 2026
Key finding
Total weight was −2.5 kg (95% CI −4.7 to −0.4, p = 0.023) lower in pooled intervention group.
This study investigated the effects of structured exercise programs on glucose metabolism and weight loss in participants after Roux-en-Y gastric bypass, finding significant weight and fat mass reductions.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of structured exercise programs on glucose metabolism and weight loss in participants after Roux-en-Y gastric bypass, finding significant weight and fat mass reductions.
Understanding the role of exercise in weight management post-gastric bypass is crucial for developing effective post-operative care strategies. While exercise can enhance weight loss, the lack of impact on glucose metabolism highlights the need for comprehensive approaches that also address metabolic health.
The study did not assess long-term effects of exercise on glucose metabolism. Sample size may limit the generalizability of the findings. No differences in quality of life or inflammation were detected.
Published in
Publication details and source links for this paper.
Stefanie L, Undine GL, Andreas O, et al. Effects of Structured Exercise Programs on Glucose Metabolism and Weight Loss Following Roux-en-Y Gastric Bypass. Langenbeck's Archives of Surgery. 2025;410(1):194. doi:10.1007/s00423-025-03731-7
Total weight was reduced by −2.5 kg (p = 0.023) in the pooled intervention group.
Fat mass decreased by −3.0 kg (p = 0.0037) according to bioelectrical impedance analysis.
Fat-free mass decreased by −4.2 kg with no significant difference between groups.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Control Group - Blinded Nutrition Therapy, Exercise therapy, Resistance training and 2-hour plasma glucose, Body fat mass, Inflammatory markers, and 4 more.
This study contributes evidence to
Primary intervention
Control Group - Blinded Nutrition Therapy
Primary outcomes
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
6
Related topics
21
Evidence pairs
849
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Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_intervention_and_outcome
Related evidence
Evidence topic
Save evidence
Core evidence
The primary outcomes reported in this study.
Control Group - Blinded Nutrition Therapy → 2-hour plasma glucose
Control Group - Blinded Nutrition Therapy → 2-hour plasma glucose
Control Group - Blinded Nutrition Therapy → Body fat mass
Control Group - Blinded Nutrition Therapy → Body fat mass
Control Group - Blinded Nutrition Therapy → Inflammatory markers
Control Group - Blinded Nutrition Therapy → Inflammatory markers
Control Group - Blinded Nutrition Therapy → Lean body mass
Control Group - Blinded Nutrition Therapy → Lean body mass
Control Group - Blinded Nutrition Therapy → lipid profiles
Control Group - Blinded Nutrition Therapy → lipid profiles
Control Group - Blinded Nutrition Therapy → Quality of life
Control Group - Blinded Nutrition Therapy → Quality of life
Control Group - Blinded Nutrition Therapy → Weight loss of 10% or more at 52 weeks
Control Group - Blinded Nutrition Therapy → Weight loss of 10% or more at 52 weeks
Exercise therapy → 2-hour plasma glucose
Exercise therapy → 2-hour plasma glucose
Exercise therapy → Weight loss of 10% or more at 52 weeks
Exercise therapy → Weight loss of 10% or more at 52 weeks
Resistance training → 2-hour plasma glucose
Resistance training → 2-hour plasma glucose
Resistance training → Inflammatory markers
Resistance training → Inflammatory markers
Resistance training → Weight loss of 10% or more at 52 weeks
Resistance training → Weight loss of 10% or more at 52 weeks
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Exercise therapy and Quality of Life Outcomes, Resistance training and Postprandial and OGTT Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Physical Activity
Physical Activity
Curated evidence collections and hubs this study is part of.
All studies on Exercise therapy
Contributes to Exercise therapy evidence base.
All studies measuring Postprandial and OGTT Glucose
Measures Postprandial and OGTT Glucose as a key outcome.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
All studies on Resistance training
Contributes to Resistance training evidence base.
All studies on Control Group - Blinded Nutrition Therapy
Contributes to Control Group - Blinded Nutrition Therapy evidence base.
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3 results
3 results
3 results
3 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
Exercise therapy may improve Quality of life.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Quality of life
EvidenceScore™ Strong | EvidenceScore™ 79.0 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Resistance training for 2-hour plasma glucose.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
2-hour plasma glucose
EvidenceScore™ Moderate | EvidenceScore™ 75.0 | neutral | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Resistance training may improve Lean body mass.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Lean body mass
EvidenceScore™ Moderate | EvidenceScore™ 73.6 | moderate positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Exercise therapy appears to improve Body fat mass.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Body fat mass
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Mixed | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
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