Last updated July 1, 2026
Key finding
An unadjusted between-group difference in HbA1c was observed (p = 0.006)
This study evaluated the safety and efficacy of Centella asiatica as a dietary supplement for glycemic control in individuals with type 2 diabetes, finding a significant reduction in HbA1c levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study's main message and where it applies.
Study focus
This study evaluated the safety and efficacy of Centella asiatica as a dietary supplement for glycemic control in individuals with type 2 diabetes, finding a significant reduction in HbA1c levels.
These findings suggest that Centella asiatica could be a beneficial dietary supplement for managing glycemic control in type 2 diabetes, potentially offering an additional strategy for patients seeking to improve their blood sugar levels and overall health.
The study's sample size may limit the generalizability of the findings. The duration of the intervention may not reflect long-term effects. The study did not measure other potential confounding factors.
Published in
Publication details and source links for this paper.
Weeratian T, Auemphon M, Tharin P, Doungkamol S. Safety and Efficacy of Centella asiatica as a Dietary Supplement for Glycemic Control in Type 2 Diabetes. Frontiers in Pharmacology. 2025;16:1680647. doi:10.3389/fphar.2025.1680647
Centella asiatica significantly reduced HbA1c levels by -0.14% (p = 0.006).
No significant differences were found in fasting plasma glucose between groups.
LDL cholesterol levels showed no significant change (p = 0.536).
Centella asiatica was well tolerated with mild gastrointestinal symptoms reported in 14.7% of participants.
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Centella asiatica (CA) extract and Adverse events incidence, Fasting Plasma Glucose (FPG), HbA1c, and 1 more.
This study contributes evidence to
Primary intervention
Centella asiatica (CA) extract
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
4
Evidence pairs
293
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Core evidence
The primary outcomes reported in this study.
Centella asiatica (CA) extract → Adverse events incidence
Centella asiatica (CA) extract → Adverse events incidence
Centella asiatica (CA) extract → Fasting Plasma Glucose (FPG)
Centella asiatica (CA) extract → Fasting Plasma Glucose (FPG)
Centella asiatica (CA) extract → LDL cholesterol
Centella asiatica (CA) extract → LDL cholesterol
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Probiotics and Synbiotics and Adverse events incidence, Probiotics and Synbiotics and Fasting Glucose.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Adverse events incidence
Measures Adverse events incidence as a key outcome.
All studies measuring Fasting Glucose
Measures Fasting Glucose as a key outcome.
All studies on Probiotics and Synbiotics
Contributes to Probiotics and Synbiotics evidence base.
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Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Probiotics and Synbiotics may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 9 supporting studies with generally consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics appears to improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
Limitations
Probiotics and Synbiotics may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Centella asiatica (CA) extract appears to improve Adverse events incidence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Adverse events incidence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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