Last updated August 25, 2026
Key finding
HRQOL score increased from baseline value (0.88±0.9) to post-intervention (0.90±0.87, P<0.001).
A community-based lifestyle intervention program improved health-related quality of life in participants at risk for type 2 diabetes.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
A community-based lifestyle intervention program improved health-related quality of life in participants at risk for type 2 diabetes.
Improving health-related quality of life is crucial for individuals at risk of type 2 diabetes, as it can enhance overall well-being and potentially reduce the risk of developing diabetes. The weight loss observed suggests that lifestyle interventions can be effective in managing health risks associated with diabetes.
The study had a single-arm design, limiting comparisons. The population was heterogeneous, which may affect generalizability. No significant changes were noted in several metabolic outcomes.
Published in
Publication details and source links for this paper.
Georgios K, Bernardo C, Aleksandra G, et al. A community-based lifestyle intervention programme aiming at T2D prevention, applied on a heterogeneous population and with varied methods, was shown to improve overall health-related quality of life to a clinically meaningful degree. PLOS ONE. 2019;14(10):e0221467. doi:10.1371/journal.pone.0221467
Health-related quality of life score increased from 0.88±0.9 to 0.90±0.87 (P<0.001).
Weight decreased by 0.8±4.0 kg (P<0.001).
No significant changes were observed in blood pressure or cholesterol levels.
Evidence network
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This study contributes evidence to Intensive lifestyle intervention for type 2 diabetes remission and Diastolic blood pressure, Fasting Plasma Glucose (FPG), HDL cholesterol, and 6 more.
This study contributes evidence to
Primary intervention
Intensive lifestyle intervention for type 2 diabetes remission
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
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Evidence pairs
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Contributes evidence
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Contributes evidence
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Contributes evidence
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Primary evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Intensive lifestyle intervention for type 2 diabetes remission → Diastolic blood pressure
Intensive lifestyle intervention for type 2 diabetes remission → Diastolic blood pressure
Intensive lifestyle intervention for type 2 diabetes remission → Fasting Plasma Glucose (FPG)
Intensive lifestyle intervention for type 2 diabetes remission → Fasting Plasma Glucose (FPG)
Intensive lifestyle intervention for type 2 diabetes remission → HDL cholesterol
Intensive lifestyle intervention for type 2 diabetes remission → HDL cholesterol
Intensive lifestyle intervention for type 2 diabetes remission → Health-related quality of life
Intensive lifestyle intervention for type 2 diabetes remission → Health-related quality of life
Intensive lifestyle intervention for type 2 diabetes remission → LDL cholesterol
Intensive lifestyle intervention for type 2 diabetes remission → LDL cholesterol
Intensive lifestyle intervention for type 2 diabetes remission → Systolic blood pressure
Intensive lifestyle intervention for type 2 diabetes remission → Systolic blood pressure
Intensive lifestyle intervention for type 2 diabetes remission → Total cholesterol
Intensive lifestyle intervention for type 2 diabetes remission → Total cholesterol
Intensive lifestyle intervention for type 2 diabetes remission → Triglycerides
Intensive lifestyle intervention for type 2 diabetes remission → Triglycerides
Intensive lifestyle intervention for type 2 diabetes remission → Weight change
Intensive lifestyle intervention for type 2 diabetes remission → Weight change
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Diabetes Self-Management Education and Support (DSMES) Programs and Blood Pressure, Diabetes Self-Management Education and Support (DSMES) Programs and Adipokine and Angiogenic Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies measuring Blood Pressure
Measures Blood Pressure as a key outcome.
All studies on Diabetes Self-Management Education and Support (DSMES) Programs
Contributes to Diabetes Self-Management Education and Support (DSMES) Programs evidence base.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
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3 results
2 results
3 results
3 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Diabetes Self-Management Education and Support (DSMES) Programs may improve Fasting Glucose.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Diabetes Self-Management Education and Support (DSMES) Programs may improve Blood Pressure.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Ranked evidence signals
Systolic blood pressure
EvidenceScore™ Strong | EvidenceScore™ 79.0 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Diastolic blood pressure
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
Diabetes Self-Management Education and Support (DSMES) Programs may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Triglycerides
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
HDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 11 supporting studies with generally consistent results and a positive effect signal.
Limitations
Diabetes Self-Management Education and Support (DSMES) Programs appears to improve Body Weight.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Weight change
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 13 supporting studies with consistent results and a positive effect signal.
Limitations
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