StrongDecrease
Hyaluronic acid (HA)
Curcuma longa extract (CLE) → Hyaluronic acid (HA)
Curcuma longa extract (CLE) → Hyaluronic acid (HA)
Evidence profile
StrongDecreaseClinical Outcomes
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Research Summary
Analyzed using Evidence Intelligence™
Curcuma longa extract improves neuropathy symptoms in type 2 diabetes
Key finding
CLE supplementation resulted in a significant reduction in neuropathy symptom score compared with placebo (P = 0.048).
This study evaluated the effects of Curcuma longa extract on neuropathy symptoms and vascular biomarkers in adults with type 2 diabetes, finding significant improvements in several measures.
Evidence strength
Moderate confidence
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Some Concerns bias
Last updated July 5, 2026Quick read
Study at a glance
The essential study design details in one scan.
Population
Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes
Intervention
Curcuma longa extract (CLE)
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Primary outcome
Neuropathy symptom score
Comparator
Placebo group
Plain-language summary
What this paper says
A plain-language read of the study's main message and where it applies.
Study focus
This study evaluated the effects of Curcuma longa extract on neuropathy symptoms and vascular biomarkers in adults with type 2 diabetes, finding significant improvements in several measures.
Clinical relevance
These findings suggest that Curcuma longa extract could be a beneficial supplement for adults with type 2 diabetes, potentially improving their quality of life by alleviating neuropathy symptoms and reducing inflammation, which are common complications of the disease.
Keep in mind
The study may have limited generalizability due to a specific participant demographic. The sample size and duration of the study may not capture long-term effects. Potential biases in self-reported outcomes could affect the reliability of symptom scores.
Published in
Journal Reference
Publication details and source links for this paper.
Drielly RV, Alanna RM, Cristina AS, Maria DCF. Effects of Curcuma longa extract supplementation on vascular, redox-inflammatory biomarkers, and neuropathy symptoms in adults with type 2 diabetes mellitus: A randomized double-blind placebo-controlled trial. European Journal of Nutrition. 2026;65(3):116. doi:10.1007/s00394-026-03963-3
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Main Effects
Curcuma longa extract reduced neuropathy symptom score by 1.5 points (P = 0.048).
Curcuma longa extract significantly decreased Syndecan-1 levels by 46.5 ng/mL (P = 0.001).
Curcuma longa extract significantly reduced Hyaluronic acid levels by 68.1 ng/mL (P = 0.002).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Curcuma longa extract (CLE) and Hyaluronic acid (HA), Matrix metalloproteinase-2 (MMP-2), Matrix metalloproteinase-9 (MMP-9), and 8 more.
This study contributes evidence to
Primary intervention
Curcuma longa extract (CLE)
Primary outcomes
- Hyaluronic acid (HA)
- Matrix metalloproteinase-2 (MMP-2)
- Matrix metalloproteinase-9 (MMP-9)
Primary intervention
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
11
Evidence pairs
11
Relationships
0
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 54
0
Related topics
11
Evidence pairs
0
Related studies
Why it is useful
- Contributes to 11 evidence relationships
- Includes primary outcome data
- Linked to 0 direct semantic evidence topics
Core evidence
Study findings
The primary outcomes reported in this study.
StrongDecrease
Matrix metalloproteinase-2 (MMP-2)
Curcuma longa extract (CLE) → Matrix metalloproteinase-2 (MMP-2)
Curcuma longa extract (CLE) → Matrix metalloproteinase-2 (MMP-2)
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
StrongDecrease
Matrix metalloproteinase-9 (MMP-9)
Curcuma longa extract (CLE) → Matrix metalloproteinase-9 (MMP-9)
Curcuma longa extract (CLE) → Matrix metalloproteinase-9 (MMP-9)
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
StrongDecrease
Neuropathy symptom score
Curcuma longa extract (CLE) → Neuropathy symptom score
Curcuma longa extract (CLE) → Neuropathy symptom score
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
StrongIncrease
Nuclear factor erythroid 2-related factor 2 (Nrf2)
Curcuma longa extract (CLE) → Nuclear factor erythroid 2-related factor 2 (Nrf2)
Curcuma longa extract (CLE) → Nuclear factor erythroid 2-related factor 2 (Nrf2)
Evidence profile
StrongIncreaseMetabolic Health
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StrongDecrease
Nuclear factor kappa B (NF-κB p65)
Curcuma longa extract (CLE) → Nuclear factor kappa B (NF-κB p65)
Curcuma longa extract (CLE) → Nuclear factor kappa B (NF-κB p65)
Evidence profile
StrongDecreaseMetabolic Health
Unlock full evidence details
StrongIncrease
Sirtuin-1 (SIRT1)
Curcuma longa extract (CLE) → Sirtuin-1 (SIRT1)
Curcuma longa extract (CLE) → Sirtuin-1 (SIRT1)
Evidence profile
StrongIncreaseClinical Outcomes
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StrongDecrease
Syndecan-1 (SDC1)
Curcuma longa extract (CLE) → Syndecan-1 (SDC1)
Curcuma longa extract (CLE) → Syndecan-1 (SDC1)
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
StrongDecrease
Syndecan-4 (SDC4)
Curcuma longa extract (CLE) → Syndecan-4 (SDC4)
Curcuma longa extract (CLE) → Syndecan-4 (SDC4)
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
StrongIncrease
Thioredoxin-1 (Trx1)
Curcuma longa extract (CLE) → Thioredoxin-1 (Trx1)
Curcuma longa extract (CLE) → Thioredoxin-1 (Trx1)
Evidence profile
StrongIncreaseClinical Outcomes
Unlock full evidence details
StrongDecrease
Thioredoxin-binding protein-2 (TBP2)
Curcuma longa extract (CLE) → Thioredoxin-binding protein-2 (TBP2)
Curcuma longa extract (CLE) → Thioredoxin-binding protein-2 (TBP2)
Evidence profile
StrongDecreaseClinical Outcomes
Unlock full evidence details
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Evidence Suggest
- Curcuma longa extract reduced Syndecan-4 levels by 46 pg/mL (P = 0.040).
- Curcuma longa extract reduced Matrix metalloproteinase-2 levels by 34.9 ng/mL (P < 0.001).
- Curcuma longa extract increased Thioredoxin-1 levels (all P < 0.05).
Who this applies to
- Adults diagnosed with type 2 diabetes.
- Individuals experiencing neuropathy symptoms related to diabetes.
Keep in Mind
- Results may not apply to all populations, as the study had specific inclusion criteria.
- Further research is needed to confirm long-term effects and safety.
- The study did not assess potential interactions with other diabetes medications.
Between the Lines
- The study may have limited generalizability due to a specific participant demographic.
- The sample size and duration of the study may not capture long-term effects.
- Potential biases in self-reported outcomes could affect the reliability of symptom scores.
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Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcuma longa extract (CLE) and Hyaluronic acid (HA), Curcuma longa extract (CLE) and Matrix metalloproteinase-2 (MMP-2).
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention-outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Curcuma longa extract (CLE) Evidence Hub
All studies on Curcuma longa extract (CLE)
1 studies
intervention_hubContributes to Curcuma longa extract (CLE) evidence base.
Hyaluronic acid (HA) Evidence Hub
All studies measuring Hyaluronic acid (HA)
1 studies
outcome_hubMeasures Hyaluronic acid (HA) as a key outcome.
Matrix metalloproteinase-2 (MMP-2) Evidence Hub
All studies measuring Matrix metalloproteinase-2 (MMP-2)
1 studies
outcome_hubMeasures Matrix metalloproteinase-2 (MMP-2) as a key outcome.
Recent Diabetes Research
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Published within the last 2 years.
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All studies on Curcuma longa extract (CLE) and Hyaluronic acid (HA)
Intervention: Curcuma longa extract (CLE)Outcome: Hyaluronic acid (HA)
1 results
All studies on Curcuma longa extract (CLE) and Matrix metalloproteinase-2 (MMP-2)
Intervention: Curcuma longa extract (CLE)Outcome: Matrix metalloproteinase-2 (MMP-2)
1 results
All studies on Curcuma longa extract (CLE)
Intervention: Curcuma longa extract (CLE)
1 results
All studies measuring Hyaluronic acid (HA)
Outcome: Hyaluronic acid (HA)
1 results
All studies measuring Matrix metalloproteinase-2 (MMP-2)
Outcome: Matrix metalloproteinase-2 (MMP-2)
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Curcuma longa extract (CLE) improve hyaluronic acid (ha)?
Emerging Evidence
Curcuma longa extract (CLE) appears to improve Hyaluronic acid (HA).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Hyaluronic acid (HA)
EvidenceScore™ Emerging | EvidenceScore™ 54.5 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Curcuma longa extract (CLE) improve matrix metalloproteinase-2 (mmp-2)?
Emerging Evidence
Curcuma longa extract (CLE) appears to improve Matrix metalloproteinase-2 (MMP-2).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Matrix metalloproteinase-2 (MMP-2)
EvidenceScore™ Emerging | EvidenceScore™ 54.5 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Curcuma longa extract (CLE) improve matrix metalloproteinase-9 (mmp-9)?
Emerging Evidence
Curcuma longa extract (CLE) appears to improve Matrix metalloproteinase-9 (MMP-9).
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Matrix metalloproteinase-9 (MMP-9)
EvidenceScore™ Emerging | EvidenceScore™ 54.5 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Curcuma longa extract (CLE) improve neuropathy symptom score?
Emerging Evidence
Curcuma longa extract (CLE) appears to improve Neuropathy symptom score.
ConsensusScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Neuropathy symptom score
EvidenceScore™ Emerging | EvidenceScore™ 54.5 | strong positive | ConsensusScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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All studies on Curcuma longa extract (CLE) and Hyaluronic acid (HA)All studies on Curcuma longa extract (CLE) and Matrix metalloproteinase-2 (MMP-2)All studies on Curcuma longa extract (CLE) and Matrix metalloproteinase-9 (MMP-9)All studies on Curcuma longa extract (CLE) and Neuropathy symptom score
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