Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Probiotic Lactobacillus casei 01 improves glycemic control in type 2 diabetes
Last updated August 22, 2026
Key finding
Total energy intake decreased significantly (p = 0.001).
This study investigated the effects of Lactobacillus casei 01 on dietary intake, body weight, and glycemic control in patients with type 2 diabetes mellitus (T2DM). The findings indicated significant reductions in energy and macronutrient intake, body weight, and glycemic markers.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of Lactobacillus casei 01 on dietary intake, body weight, and glycemic control in patients with type 2 diabetes mellitus (T2DM). The findings indicated significant reductions in energy and macronutrient intake, body weight, and glycemic markers.
Clinical relevance
These findings suggest that Lactobacillus casei 01 could be a beneficial adjunct therapy for managing dietary habits and glycemic control in patients with T2DM. By improving these parameters, it may help reduce the risk of diabetes-related complications and improve overall health outcomes.
Keep in mind
The sample size may limit the generalizability of the findings. The study duration may not be sufficient to assess long-term effects. Potential biases in self-reported dietary intake could affect accuracy.
Published in
Journal Reference
Publication details and source links for this paper.
Leila K, Beitullah A, Mohammad AJ, Tohid H, Mehran MA, Ismail F. The effect of Lactobacillus casei 01 on dietary intake, body weight, and glycemic control in patients with T2DM. Diabetology & Metabolic Syndrome. 2019;11:5. doi:10.1186/s13098-019-0400-7
Main Effects
Total energy intake decreased significantly by 54.32 kcal (p = 0.001).
Body weight decreased significantly by 1.52 kg (p < 0.001).
Fasting plasma glucose levels decreased significantly (p = 0.013).
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Lactobacillus casei 01 supplementation and BMI, Body weight, Carbohydrate intake, and 9 more.
This study contributes evidence to
Primary intervention
Lactobacillus casei 01 supplementation
Primary outcomes
- BMI
- Body weight
- Carbohydrate intake
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
12
Evidence pairs
12
Relationships
2
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 64
2
Related topics
12
Evidence pairs
579
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 12 evidence relationships
- Includes primary outcome data
- Linked to 2 direct semantic evidence topics
Topic contributions
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
Weight Loss
matched_outcome
Related evidence
Evidence topic
Glycemic Control
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Body weight
Lactobacillus casei 01 supplementation → Body weight
Lactobacillus casei 01 supplementation → Body weight
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerDaily intake of saturated fat in grams
Lactobacillus casei 01 supplementation → Daily intake of saturated fat in grams
Lactobacillus casei 01 supplementation → Daily intake of saturated fat in grams
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerFasting Plasma Glucose (FPG)
Lactobacillus casei 01 supplementation → Fasting Plasma Glucose (FPG)
Lactobacillus casei 01 supplementation → Fasting Plasma Glucose (FPG)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerInsulin
Lactobacillus casei 01 supplementation → Insulin
Lactobacillus casei 01 supplementation → Insulin
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerInsulin resistance
Lactobacillus casei 01 supplementation → Insulin resistance
Lactobacillus casei 01 supplementation → Insulin resistance
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerPercentage contribution of ultra-processed foods to total energy intake
Lactobacillus casei 01 supplementation → Percentage contribution of ultra-processed foods to total energy intake
Lactobacillus casei 01 supplementation → Percentage contribution of ultra-processed foods to total energy intake
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 25
- Negative
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerProtein intake change
Lactobacillus casei 01 supplementation → Protein intake change
Lactobacillus casei 01 supplementation → Protein intake change
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 25
- Negative
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerSerum fetuin-A levels
Lactobacillus casei 01 supplementation → Serum fetuin-A levels
Lactobacillus casei 01 supplementation → Serum fetuin-A levels
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerSirtuin-1 (SIRT1)
Lactobacillus casei 01 supplementation → Sirtuin-1 (SIRT1)
Lactobacillus casei 01 supplementation → Sirtuin-1 (SIRT1)
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerWaist circumference
Lactobacillus casei 01 supplementation → Waist circumference
Lactobacillus casei 01 supplementation → Waist circumference
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerCarbohydrate intake
Lactobacillus casei 01 supplementation → Carbohydrate intake
Lactobacillus casei 01 supplementation → Carbohydrate intake
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
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Evidence Suggest
- Total energy intake decreased by 54.32 kcal (p = 0.001).
- Body weight reduced by 1.52 kg (p < 0.001).
- Fasting plasma glucose levels significantly decreased (p = 0.013).
Who this applies to
- Adults diagnosed with type 2 diabetes mellitus.
- Individuals looking to improve dietary habits and glycemic control.
Keep in Mind
- Results may not apply to all populations with diabetes.
- Further research is needed to confirm long-term benefits.
- The study focused on a specific probiotic strain, limiting broader applicability.
Between the Lines
- The sample size may limit the generalizability of the findings.
- The study duration may not be sufficient to assess long-term effects.
- Potential biases in self-reported dietary intake could affect accuracy.
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lactobacillus casei 01 supplementation and Body Mass Index, Lactobacillus casei 01 supplementation and Body Weight.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
1 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Body Weight Evidence Hub
All studies measuring Body Weight
1 studies
outcome_hubMeasures Body Weight as a key outcome.
Lactobacillus casei 01 supplementation Evidence Hub
All studies on Lactobacillus casei 01 supplementation
1 studies
intervention_hubContributes to Lactobacillus casei 01 supplementation evidence base.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Lactobacillus casei 01 supplementation and BMI
Intervention: Lactobacillus casei 01 supplementationOutcome: BMI
1 results
All studies on Lactobacillus casei 01 supplementation and Body weight
Intervention: Lactobacillus casei 01 supplementationOutcome: Body weight
1 results
All studies on Lactobacillus casei 01 supplementation
Intervention: Lactobacillus casei 01 supplementation
1 results
All studies measuring BMI
Outcome: BMI
1 results
All studies measuring Body weight
Outcome: Body weight
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Lactobacillus casei 01 supplementation affect bmi?
Emerging Evidence
Lactobacillus casei 01 supplementation appears to improve BMI.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Lactobacillus casei 01 supplementation affect body weight?
Emerging Evidence
Lactobacillus casei 01 supplementation appears to improve Body weight.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Body weight
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Lactobacillus casei 01 supplementation improve carbohydrate intake?
Emerging Evidence
Lactobacillus casei 01 supplementation appears to improve Carbohydrate intake.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Carbohydrate intake
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Lactobacillus casei 01 supplementation improve daily intake of saturated fat in grams?
Emerging Evidence
Lactobacillus casei 01 supplementation appears to improve Daily intake of saturated fat in grams.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Daily intake of saturated fat in grams
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
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All studies on Lactobacillus casei 01 supplementation and BMIAll studies on Lactobacillus casei 01 supplementation and Body weightAll studies on Lactobacillus casei 01 supplementation and Carbohydrate intakeAll studies on Lactobacillus casei 01 supplementation and Daily intake of saturated fat in grams
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