Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerResearch Summary
Analyzed using Evidence Intelligence™
Curcumin-Piperine Improves Mental Health and Sleep in Diabetic Retinopathy
Last updated June 19, 2026
Key finding
Quality of sleep decreased by 0.91 ± 1.28
The study evaluated the effects of a curcumin-piperine combination on mental health and physical factors in diabetic retinopathy patients, showing significant improvements in various outcomes.
Quick read
Study at a glance
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
What this paper says
A plain-language read of the study’s main message and where it applies.
Study focus
The study evaluated the effects of a curcumin-piperine combination on mental health and physical factors in diabetic retinopathy patients, showing significant improvements in various outcomes.
Clinical relevance
These findings suggest that curcumin and piperine may offer a complementary approach to managing mental health and physical health issues in patients with diabetic retinopathy, potentially enhancing their overall quality of life. Given the prevalence of mental health issues in chronic disease populations, this combination could be a valuable addition to treatment protocols.
Keep in mind
Limited sample size may affect generalizability Short duration of the study may not capture long-term effects Potential for unmeasured confounders impacting results
Published in
Journal Reference
Publication details and source links for this paper.
Sepide A, Alireza D, Amirhossein S, et al. The Effect of Curcumin-Piperine Combination on Mental Health and Anthropometric Indices in Patients with Diabetic Retinopathy: A Randomized Controlled Trial. International Journal of Preventive Medicine. 2026;17:14. doi:10.4103/ijpvm.ijpvm_276_23
Main Effects
Quality of sleep improved, decreasing by 0.91 ± 1.28 (p=0.025)
Depression decreased by 1.61 ± 2.23 (p=0.001)
Anxiety decreased by 1.31 ± 2.23 (p=0.005)
Body Mass Index (BMI) decreased by 0.08 ± 0.15 (p=0.003)
Evidence network
How this study fits
Understand where this research contributes within the broader evidence network.
Evidence Context
This study contributes evidence to Curcumin plus piperine and Anxiety score, BMI, Depression score, and 3 more.
This study contributes evidence to
Primary intervention
Curcumin plus piperine
Primary outcomes
- Anxiety score
- BMI
- Depression score
Evidence topics
Primary intervention
Primary outcomes
Evidence relationships
Intervention and outcome relationships this study adds to the evidence network.
6
Evidence pairs
6
Relationships
1
Evidence topics
contributes_evidence
Editorial context
Why this study matters
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
Moderate contributionModerate confidenceNetwork score: 63
1
Related topics
6
Evidence pairs
177
Related studies
High relevance in at least one topic
Why it is useful
- Contributes to 6 evidence relationships
- Includes primary outcome data
- Linked to 1 direct semantic evidence topic
Topic contributions
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Curcumin Supplements and Body Mass Index
Related evidence
Evidence relationship
Curcumin Supplements and Quality of Life Outcomes
Save evidence
Evidence relationship
Curcumin Supplements and Body Composition
Save evidence
Core evidence
Study findings
The primary outcomes reported in this study.
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerWaist circumference
Curcumin plus piperine → Waist circumference
Curcumin plus piperine → Waist circumference
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
Add to Evidence TrackerEvidence Library
Build your evidence library
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Evidence Suggest
- Quality of sleep improved significantly with a decrease of 0.91 points.
- Depression levels decreased significantly by 1.61 points.
- Anxiety levels decreased significantly by 1.31 points.
Who this applies to
- Adults diagnosed with diabetic retinopathy
- Patients experiencing mental health issues such as depression and anxiety
Keep in Mind
- Results may not be applicable to all diabetic retinopathy patients.
- Further research is needed to confirm long-term effects.
- The study did not assess other potential confounding factors.
Between the Lines
- Limited sample size may affect generalizability
- Short duration of the study may not capture long-term effects
- Potential for unmeasured confounders impacting results
Evidence Library
Build your evidence library
Save research, organize studies, and quickly find important evidence again.
Connected Evidence
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Mental Health, Curcumin Supplements and Body Mass Index.
Related evidence relationships
Explore in Evidence ExplorerThis study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curcumin Supplements → Mental Health
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Curcumin Supplements → Body Mass Index
Supplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceSupplements
Evidence Intelligence™
- EvidenceScore™
- Emerging
- Score 59 · Based on 1 study
- ImpactScore™
- 100
- Very Positive
- ConsistencyScore™
- unclear
- Not enough independent studies
Supporting studies: Based on 1 study
View evidenceIncluded in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Mass Index Evidence Hub
All studies measuring Body Mass Index
1 studies
outcome_hubMeasures Body Mass Index as a key outcome.
Curcumin Supplements Evidence Hub
All studies on Curcumin Supplements
1 studies
intervention_hubContributes to Curcumin Supplements evidence base.
Mental Health Evidence Hub
All studies measuring Mental Health
1 studies
outcome_hubMeasures Mental Health as a key outcome.
Quality of Life Outcomes Evidence Hub
All studies measuring Quality of Life Outcomes
1 studies
outcome_hubMeasures Quality of Life Outcomes as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in Evidence Explorer
Jump to pre-filtered views in Evidence Explorer.
All studies on Curcumin plus piperine and Anxiety score
Intervention: Curcumin plus piperineOutcome: Anxiety score
1 results
All studies on Curcumin plus piperine and BMI
Intervention: Curcumin plus piperineOutcome: BMI
1 results
All studies on Curcumin plus piperine
Intervention: Curcumin plus piperine
1 results
All studies measuring Anxiety score
Outcome: Anxiety score
1 results
All studies measuring BMI
Outcome: BMI
1 results
Questions answered by this study
Generated from the study's connected evidence using Evidence Intelligence™.
Does Curcumin Supplements improve quality of life outcomes?
Moderate Evidence
Curcumin Supplements may improve Quality of Life Outcomes.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
Sleep quality
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only a small number of supporting studies are available.
- Population details are unavailable.
Does Curcumin Supplements affect body mass index?
Moderate Evidence
Curcumin Supplements may improve Body Mass Index.
ConsistencyScore™: Results are mixed and should be interpreted cautiously.
Evidence caveat: The available evidence reports mixed findings.
Ranked evidence signals
- 1
BMI
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is cautious because the available studies report mixed findings.
Limitations
- Only a small number of supporting studies are available.
- Population details are unavailable.
Does Curcumin Supplements improve mental health?
Emerging Evidence
Curcumin Supplements appears to improve Mental Health.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Anxiety score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
- 2
Depression score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
- 3
Stress score
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Does Curcumin Supplements improve body composition?
Emerging Evidence
Curcumin Supplements appears to improve Body Composition.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
- 1
Waist circumference
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
- Only one supporting study is available.
- Consistency cannot yet be determined.
- Population details are unavailable.
Next steps
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