Research Summary
Curcumin-Piperine Improves Mental Health and Sleep in Diabetic Retinopathy
Moderate confidence
Low bias
Last updated June 19, 2026Key Takeaway:
The study evaluated the effects of a curcumin-piperine combination on mental health and physical factors in diabetic retinopathy patients, showing significant improvements in various outcomes.
Study at a Glance
What was studied
Curcumin-piperine combination on mental health status and anthropometric indices in patients with diabetic retinopathy.
Participants
Young Adult (19–39), Middle Aged (40-64)
Male, Female
with T2 Diabetes
Intervention
Curcumin-piperine combination, Placebo
Outcomes
Quality of sleep, Depression, Anxiety, Stress, Body Mass Index (BMI), Waist Circumference (WC), Quality of sleep (Placebo), Depression (Placebo), Anxiety (Placebo), Stress (Placebo), Body Mass Index (BMI) (Placebo), Waist Circumference (WC) (Placebo)
Funding
Non-Industry Sponsored
Save this study and add notes to your research library.
Main Effects
Quality of sleep improved, decreasing by 0.91 ± 1.28 (p=0.025)
Depression decreased by 1.61 ± 2.23 (p=0.001)
Anxiety decreased by 1.31 ± 2.23 (p=0.005)
Body Mass Index (BMI) decreased by 0.08 ± 0.15 (p=0.003)
Evidence Summary
| Intervention | Outcome | Measured Change | Study Effect |
|---|---|---|---|
 Curcumin plus piperine (Supplements) |  Anxiety score (Patient-Reported) | Decrease | Strong |
Curcumin plus piperine (Supplements) |  BMI (Weight & Anthropometrics) | Decrease | Strong |
Curcumin plus piperine (Supplements) | Depression score (Patient-Reported) | Decrease | Strong |
Curcumin plus piperine (Supplements) | Sleep quality (Patient-Reported) | Decrease | Strong |
Curcumin plus piperine (Supplements) | Stress score (Patient-Reported) | Decrease | Strong |
Curcumin plus piperine (Supplements) | Waist circumference (Weight & Anthropometrics) | Decrease | Strong |
 Placebo (Medications) | Anxiety (Placebo) (Patient-Reported) | No Change | Unclear |
Placebo (Medications) | BMI (Weight & Anthropometrics) | No Change | Unclear |
Placebo (Medications) | Depression (Placebo) (Patient-Reported) | No Change | Unclear |
Placebo (Medications) | Sleep quality (Patient-Reported) | No Change | Unclear |
Placebo (Medications) | Stress (Placebo) (Patient-Reported) | No Change | Unclear |
Placebo (Medications) | Waist circumference (Weight & Anthropometrics) | No Change | Unclear |
Unlock Full Evidence Analysis
Create a free account to access effectiveness ratings, evidence strength and depth scores, consistency analysis, and direct links to all supporting studies.
Evidence Suggest
- Quality of sleep improved significantly with a decrease of 0.91 points.
- Depression levels decreased significantly by 1.61 points.
- Anxiety levels decreased significantly by 1.31 points.
Who this applies to
- Adults diagnosed with diabetic retinopathy
- Patients experiencing mental health issues such as depression and anxiety
Keep in Mind
- Results may not be applicable to all diabetic retinopathy patients.
- Further research is needed to confirm long-term effects.
- The study did not assess other potential confounding factors.
Between the Lines
- Limited sample size may affect generalizability
- Short duration of the study may not capture long-term effects
- Potential for unmeasured confounders impacting results
Unlock Full Analysis
Create a free account to unlock the bias score, detailed effectiveness analysis, and clinical outcomes for this study.
Already have an account?
Journal Reference
Sepide A, Alireza D, Amirhossein S, et al. The Effect of Curcumin-Piperine Combination on Mental Health and Anthropometric Indices in Patients with Diabetic Retinopathy: A Randomized Controlled Trial. International Journal of Preventive Medicine. 2026;17:14. doi:10.4103/ijpvm.ijpvm_276_23
Connected Evidence
Discover how this study fits into the broader diabetes evidence landscape.
This study contributes to evidence on Botanical Supplements and Mental Health, Botanical Supplements and Body Weight.
Related evidence relationships
Explore in Evidence ArchiveThis study contributes to the evidence on the following intervention–outcome relationships.
Included in these evidence collections
Curated evidence collections and hubs this study is part of.
Body Weight Evidence Hub
All studies measuring Body Weight
1 studies
outcome_hubMeasures Body Weight as a key outcome.
Botanical Supplements Evidence Hub
All studies on Botanical Supplements
1 studies
intervention_hubContributes to Botanical Supplements evidence base.
Mental Health Evidence Hub
All studies measuring Mental Health
1 studies
outcome_hubMeasures Mental Health as a key outcome.
Quality of Life Evidence Hub
All studies measuring Quality of Life
1 studies
outcome_hubMeasures Quality of Life as a key outcome.
Recent Diabetes Research
Latest published studies
recency_collection
Published within the last 2 years.
Explore more in the evidence archive
Jump to pre-filtered views in the evidence archive.
All studies on Curcumin plus piperine and Anxiety score
Intervention: Curcumin plus piperineOutcome: Anxiety score
1 results
All studies on Curcumin plus piperine and BMI
Intervention: Curcumin plus piperineOutcome: BMI
1 results
All studies on Curcumin plus piperine
Intervention: Curcumin plus piperine
1 results
All studies measuring Anxiety score
Outcome: Anxiety score
1 results
All studies measuring BMI
Outcome: BMI
1 results
Questions this evidence helps answer
Key clinical and research questions this study contributes to.
Does curcumin plus piperine improve Anxiety score?
Based on connected evidence for Curcumin plus piperine and Anxiety score.
Does curcumin plus piperine affect BMI in people with diabetes?
Exploring evidence on Curcumin plus piperine and BMI outcomes.
What does the evidence say about curcumin plus piperine and Sleep quality?
Review of studies examining Curcumin plus piperine and Sleep quality.
No ads. No tracking.
Focused on evidence, not advertising.
Secure & private
Your data is always protected.
Always up to date
New studies added every day.