Last updated July 6, 2026
Key finding
Curcumin-piperine significantly increased total antioxidant capacity (0.86 ± 0.66 vs. 0.45 ± 0.89; P = 0.022)
The study evaluated the effects of curcumin-piperine supplementation on oxidative stress and kidney function in diabetic retinopathy patients, finding significant improvements in antioxidant capacity and creatinine levels.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
Save research, organize studies, and quickly find important evidence again.
Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
The study evaluated the effects of curcumin-piperine supplementation on oxidative stress and kidney function in diabetic retinopathy patients, finding significant improvements in antioxidant capacity and creatinine levels.
These findings are significant as they highlight a potential therapeutic role for curcumin-piperine in reducing oxidative stress and improving kidney function in patients with diabetic retinopathy. Given the increasing prevalence of diabetes and its complications, such as retinopathy, identifying effective dietary supplements could enhance patient care and outcomes.
Limited sample size may affect generalizability. Short duration of the intervention might not capture long-term effects. No significant effects observed on several other health markers.
Published in
Publication details and source links for this paper.
Sepide A, Alireza D, Amirhossein S, et al. Curcumin-Piperine Supplementation Improves Oxidative Stress and Reduces Creatinine in Diabetic Retinopathy. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences. 2024;29:64. doi:10.4103/jrms.jrms_174_24
Curcumin-piperine significantly increased total antioxidant capacity (0.86 ± 0.66 vs. 0.45 ± 0.89; P = 0.022)
Curcumin-piperine significantly increased superoxide dismutase levels (0.77 ± 2.11 vs. -0.45 ± 3.08; P = 0.031)
Curcumin-piperine decreased serum creatinine levels (-0.04 ± 0.16 vs. 0.03 ± 0.05; P = 0.042)
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Curcumin plus piperine and Blood urea nitrogen (BUN), C-reactive protein, Fasting Plasma Glucose (FPG), and 7 more.
This study contributes evidence to
Primary intervention
Curcumin plus piperine
Primary outcomes
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
See why this paper is useful beyond its individual results.
Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
10
Evidence pairs
923
Related studies
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
Save studies and evidence pages, organize your personal Evidence Tracker, and keep the research you care about in one place.
Primary evidence
Evidence relationship
Related evidence
Evidence relationship
Save evidence
Evidence relationship
Save evidence
Core evidence
The primary outcomes reported in this study.
Curcumin plus piperine → Blood urea nitrogen (BUN)
Curcumin plus piperine → Blood urea nitrogen (BUN)
Curcumin plus piperine → C-reactive protein
Curcumin plus piperine → C-reactive protein
Curcumin plus piperine → Fasting Plasma Glucose (FPG)
Curcumin plus piperine → Fasting Plasma Glucose (FPG)
Curcumin plus piperine → Malondialdehyde (MDA)
Curcumin plus piperine → Malondialdehyde (MDA)
Curcumin plus piperine → Optical coherence tomography
Curcumin plus piperine → Optical coherence tomography
Curcumin plus piperine → Optical coherence tomography angiography
Curcumin plus piperine → Optical coherence tomography angiography
Curcumin plus piperine → Superoxide Dismutase (SOD)
Curcumin plus piperine → Superoxide Dismutase (SOD)
Curcumin plus piperine → Total Antioxidant Capacity (TAC)
Curcumin plus piperine → Total Antioxidant Capacity (TAC)
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Evidence Library
Save research, organize studies, and quickly find important evidence again.
Explore related studies, evidence collections, and research questions.
Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Curcumin Supplements and Blood urea nitrogen (BUN), Curcumin Supplements and Inflammatory Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Supplements
Curated evidence collections and hubs this study is part of.
All studies measuring Blood urea nitrogen (BUN)
Measures Blood urea nitrogen (BUN) as a key outcome.
All studies on Curcumin Supplements
Contributes to Curcumin Supplements evidence base.
All studies measuring Inflammatory Markers
Measures Inflammatory Markers as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
Curcumin Supplements appears to improve Inflammatory Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
C-reactive protein
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements appears to improve Oxidative Stress Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Malondialdehyde (MDA)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements appears to improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Superoxide Dismutase (SOD)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Total Antioxidant Capacity (TAC)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Triglycerides
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 4 supporting studies with consistent results and a positive effect signal.
Limitations
Curcumin Supplements may improve Fasting Glucose.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Fasting Plasma Glucose (FPG)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 3 supporting studies with generally consistent results and a positive effect signal.
Limitations
Next steps
Choose a next path through related evidence topics, Evidence Explorer views, and research summaries.
Follow the topics this study contributes to.
Open broader Evidence Explorer views for this relationship.
Read related research summaries.
Focused on evidence, not advertising.
Your data is always protected.
New studies added every day.
