Research Summary

Analyzed using Evidence Intelligence™

Curcumin-Piperine May Improve Oxidative Stress in Diabetic Retinopathy

Key finding

Curcumin-piperine significantly increased total antioxidant capacity (0.86 ± 0.66 vs. 0.45 ± 0.89; P = 0.022)

The study evaluated the effects of curcumin-piperine supplementation on oxidative stress and kidney function in diabetic retinopathy patients, finding significant improvements in antioxidant capacity and creatinine levels.

Evidence strength

Moderate confidence

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Some Concerns bias

Last updated July 6, 2026

Quick read

Study at a glance

The essential study design details in one scan.

Population

Young Adult (19–39), Middle Aged (40-64), Male, Female, Asia-Pacific (APAC), with T2 Diabetes

Intervention

Curcumin-piperine

Study type

RCTs

Follow-up

Medium-Term (3–12 mo)

Primary outcome

Total antioxidant capacity

Comparator

Placebo Group

Plain-language summary

What this paper says

A plain-language read of the study's main message and where it applies.

Study focus

Clinical relevance

These findings are significant as they highlight a potential therapeutic role for curcumin-piperine in reducing oxidative stress and improving kidney function in patients with diabetic retinopathy. Given the increasing prevalence of diabetes and its complications, such as retinopathy, identifying effective dietary supplements could enhance patient care and outcomes.

Keep in mind

Limited sample size may affect generalizability. Short duration of the intervention might not capture long-term effects. No significant effects observed on several other health markers.

Published in

Journal Reference

Publication details and source links for this paper.

Sepide A, Alireza D, Amirhossein S, et al. Curcumin-Piperine Supplementation Improves Oxidative Stress and Reduces Creatinine in Diabetic Retinopathy. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences. 2024;29:64. doi:10.4103/jrms.jrms_174_24

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Main Effects

Curcumin-piperine significantly increased total antioxidant capacity (0.86 ± 0.66 vs. 0.45 ± 0.89; P = 0.022)

Curcumin-piperine significantly increased superoxide dismutase levels (0.77 ± 2.11 vs. -0.45 ± 3.08; P = 0.031)

Curcumin-piperine decreased serum creatinine levels (-0.04 ± 0.16 vs. 0.03 ± 0.05; P = 0.042)

Evidence network

How this study fits

Understand where this research contributes within the broader evidence network.

Evidence Context

This study contributes evidence to Curcumin plus piperine and Blood urea nitrogen (BUN), C-reactive protein, Fasting Plasma Glucose (FPG), and 7 more.

This study contributes evidence to

Intervention

Curcumin plus piperine

Outcome

Blood urea nitrogen (BUN)

Evidence topic

Supplements and Nutraceuticals

Primary intervention

Curcumin plus piperine

Primary outcomes

Blood urea nitrogen (BUN)
C-reactive protein
Fasting Plasma Glucose (FPG)

Evidence topics

Supplements and Nutraceuticals Inflammatory and Vascular Markers Glycemic Control

Primary intervention

Curcumin plus piperine

Primary outcomes

Blood urea nitrogen (BUN)C-reactive protein Fasting Plasma Glucose (FPG)

Evidence relationships

Intervention and outcome relationships this study adds to the evidence network.

Evidence pairs

Relationships

Evidence topics

contributes_evidence

Editorial context

Why this study matters

See why this paper is useful beyond its individual results.

Evidence network role

This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.

Moderate contributionModerate confidenceNetwork score: 68

Why it is useful

Contributes to 10 evidence relationships
Includes primary outcome data
Linked to 3 direct semantic evidence topics

Topic contributions

Evidence topic

Contributes evidence

Evidence topic

Contributes evidence

Evidence topic

Curcumin plus piperine → Triglycerides

Evidence profile

NoneNo ChangeMetabolic Health

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Evidence Suggest

Total antioxidant capacity increased by 0.86 nmol Trolox equivalent/mL (P = 0.022).
Superoxide dismutase activity improved by 0.77 U SOD activity/mL (P = 0.031).
Serum creatinine decreased by -0.04 mg/dL (P = 0.042).

Who this applies to

Adults diagnosed with diabetic retinopathy.
Individuals experiencing oxidative stress related to diabetes.

Keep in Mind

Results may not apply to populations outside the study group.
Further research is needed to confirm long-term benefits.
Effects on other health markers were not significant.

Between the Lines

Limited sample size may affect generalizability.
Short duration of the intervention might not capture long-term effects.
No significant effects observed on several other health markers.

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Connected Evidence

Explore related studies, evidence collections, and research questions.

Relationships organized using the Dediabetes Evidence Intelligence™ framework.

This study contributes to evidence on Curcumin Supplements and Oxidative Stress Markers, Curcumin Supplements and Kidney Function.

Related evidence relationships

Explore in Evidence Archive

This study contributes to the evidence on the following intervention-outcome relationships.

Curcumin SupplementsOxidative Stress Markers

Supplements

1 studies

Detailed evidence

Curcumin SupplementsKidney Function

Supplements

Latest published studies

recency_collection

Published within the last 2 years.

Generated from the study's connected evidence using Evidence Intelligence™.

Does Curcumin Supplements improve kidney function?

Emerging Evidence

Curcumin Supplements appears to improve Kidney Function.

ConsensusScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Serum creatinine
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study

Why this answer: This answer is based on a single supporting study.

Limitations

Only one supporting study is available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Curcumin Supplements improve oxidative stress markers?

Emerging Evidence

Curcumin Supplements appears to improve Oxidative Stress Markers.

ConsensusScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Malondialdehyde (MDA)
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study

Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.

Limitations

Only a small number of supporting studies are available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Curcumin Supplements improve adipokine and angiogenic markers?

Emerging Evidence

Curcumin Supplements appears to improve Adipokine and Angiogenic Markers.

ConsensusScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
Total Antioxidant Capacity (TAC)
EvidenceScore™ Emerging | EvidenceScore™ 51.7 | strong positive | ConsensusScore™ Unclear | 1 study
2
Triglycerides
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study

Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.

Limitations

Only a small number of supporting studies are available.
Consistency cannot yet be determined.
Population details are unavailable.

View Full Evidence

Does Curcumin Supplements improve inflammatory markers?

Emerging Evidence

Current evidence does not show a clear benefit of Curcumin Supplements for Inflammatory Markers.

ConsensusScore™: Consistency cannot yet be determined from the available evidence.

Ranked evidence signals

1
C-reactive protein
EvidenceScore™ Limited | EvidenceScore™ 34.2 | neutral | ConsensusScore™ Unclear | 1 study

Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.

Limitations

Only a small number of supporting studies are available.
Consistency cannot yet be determined.
Population details are unavailable.

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Next steps

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Evidence topics

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Supplements and Nutraceuticals Evidence Hub Inflammatory and Vascular Markers Evidence Hub Glycemic Control Evidence Hub

Explore in archive

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All studies on Curcumin plus piperine and Malondialdehyde (MDA)All studies on Curcumin plus piperine and Serum creatinine All studies on Curcumin plus piperine and Superoxide Dismutase (SOD)All studies on Curcumin plus piperine and Total Antioxidant Capacity (TAC)

Related research

Read related research summaries.

Curcumin-Piperine Improves Mental Health and Sleep in Diabetic Retinopathy Curcumin may improve inflammation and glycemic control in diabetes EWP supplementation improves nutrition and oxidative stress in diabetes.HRS-7535 improves glycemic control in adults with type 2 diabetes Coriander Seed Improves Glycemic Control in Type 2 Diabetes

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