Last updated July 6, 2026
Key finding
The dapagliflozin group showed significant decreases in BMI.
This study compared the effects of dapagliflozin and vitamin E in patients with metabolic dysfunction-associated steatotic liver disease and type 2 diabetes, finding significant improvements in several metabolic parameters with dapagliflozin.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Medium-Term (3–12 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study compared the effects of dapagliflozin and vitamin E in patients with metabolic dysfunction-associated steatotic liver disease and type 2 diabetes, finding significant improvements in several metabolic parameters with dapagliflozin.
This study highlights the potential of dapagliflozin as a more effective treatment option for patients with metabolic dysfunction-associated steatotic liver disease and type 2 diabetes, which could lead to better management of these conditions and improved patient outcomes.
Intergroup differences in liver enzyme reductions were not significant. No changes were observed in type IV collagen levels. The study may have limited generalizability due to specific population characteristics.
Published in
Publication details and source links for this paper.
Hiroo F, Kazuyoshi K, Reiko Y, et al. Dapagliflozin versus Vitamin E in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes: A Randomized Controlled Trial. Frontiers in Medicine. 2025;12:1542741. doi:10.3389/fmed.2025.1542741
Dapagliflozin group showed significant decreases in BMI.
Dapagliflozin group showed significant decreases in HbA1c.
Dapagliflozin group showed significant decreases in LDL cholesterol.
Both groups demonstrated significant reductions in serum AST and ALT levels.
Evidence network
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This study contributes evidence to Dapagliflozin and AST, Alanine Aminotransferase (ALT), BMI, and 8 more.
This study contributes evidence to
Primary intervention
Dapagliflozin
Primary outcomes
Evidence topics
Primary intervention
Primary outcomes
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
3
Related topics
11
Evidence pairs
685
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Contributes evidence
Evidence topic
Contributes evidence
Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence relationship
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Core evidence
The primary outcomes reported in this study.
Dapagliflozin → Alanine Aminotransferase (ALT)
Dapagliflozin → Alanine Aminotransferase (ALT)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on SGLT2 Inhibitors and HbA1c, SGLT2 Inhibitors and Body Mass Index.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring HbA1c
Measures HbA1c as a key outcome.
All studies on SGLT2 Inhibitors
Contributes to SGLT2 Inhibitors evidence base.
All studies measuring Body Mass Index
Measures Body Mass Index as a key outcome.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
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Published within the last 2 years.
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7 results
3 results
7 results
7 results
3 results
Generated from the study's connected evidence using Evidence Intelligence™.
SGLT2 Inhibitors may improve HbA1c.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
HbA1c
EvidenceScore™ Strong | EvidenceScore™ 79.4 | moderate positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 19 supporting studies with consistent results and a positive effect signal.
Limitations
SGLT2 Inhibitors may improve Adipokine and Angiogenic Markers.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Alanine Aminotransferase (ALT)
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | moderate positive | ConsistencyScore™ Mixed | 1 study
LDL cholesterol
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 9 supporting studies with consistent results and a positive effect signal.
Limitations
SGLT2 Inhibitors appears to improve Body Mass Index.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
BMI
EvidenceScore™ Moderate | EvidenceScore™ 73.1 | strong positive | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on 6 supporting studies with consistent results and a positive effect signal.
Limitations
SGLT2 Inhibitors appears to improve Body Composition.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Body fat mass
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a small number of supporting studies and should be interpreted cautiously.
Limitations
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