Last updated July 6, 2026
Key finding
Trabecular thickness was significantly higher in the dapagliflozin group (0.230 ± 0.02 vs 0.218 ± 0.01, p=0.003).
This study investigated the effects of dapagliflozin on bone metabolism in post-menopausal women with type 2 diabetes, finding significant improvements in trabecular and cortical thickness.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Long-Term (1–5 y)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study investigated the effects of dapagliflozin on bone metabolism in post-menopausal women with type 2 diabetes, finding significant improvements in trabecular and cortical thickness.
Understanding the impact of dapagliflozin on bone metabolism is crucial for managing the health of post-menopausal women with type 2 diabetes, a group at increased risk for osteoporosis. The findings suggest that dapagliflozin may offer additional benefits beyond glucose control, potentially improving bone health and reducing fracture risk in this population.
The study did not measure long-term effects on fracture risk. Sample size and demographic characteristics may limit generalizability. The study design does not allow for causal conclusions.
Published in
Publication details and source links for this paper.
Sanjay KB, Liza D, Mintu B, et al. Effects of Dapagliflozin on Bone Metabolism in Post-Menopausal Women with Type 2 Diabetes. Journal of the Endocrine Society. 2024;8(Suppl 1):bvae163.370. doi:10.1210/jendso/bvae163.370
Trabecular thickness was significantly higher in the dapagliflozin group (0.230 ± 0.02 vs 0.218 ± 0.01, p=0.003).
Cortical thickness was significantly higher in the dapagliflozin group (1.104 ± 0.2 vs 0.998 ± 0.2, p=0.04).
Intra-cortical porosity was significantly higher in the dapagliflozin group (0.008 ± 0.005 vs 0.005 ± 0.003, p=0.020).
Evidence network
Understand where this research contributes within the broader evidence network.
This study contributes evidence to Dapagliflozin and Bone mineral density (BMD), Bone mineral density (BMD) at distal radius, Bone mineral density (BMD) at femoral neck, and 7 more.
This study contributes evidence to
Primary intervention
Dapagliflozin
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
10
Evidence pairs
33
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Evidence topic
Contributes evidence
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Primary evidence
Evidence relationship
Related evidence
Evidence relationship
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Evidence topic
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Core evidence
The primary outcomes reported in this study.
Dapagliflozin → Bone mineral density (BMD)
Dapagliflozin → Bone mineral density (BMD)
Dapagliflozin → Bone mineral density (BMD) at distal radius
Dapagliflozin → Bone mineral density (BMD) at distal radius
Dapagliflozin → Bone mineral density (BMD) at femoral neck
Dapagliflozin → Bone mineral density (BMD) at femoral neck
Dapagliflozin → Cortical pore diameter (Ct.Po.Dm) at radius
Dapagliflozin → Cortical pore diameter (Ct.Po.Dm) at radius
Dapagliflozin → Cortical pore diameter (Ct.Po.Dm) at tibia
Dapagliflozin → Cortical pore diameter (Ct.Po.Dm) at tibia
Dapagliflozin → Cortical thickness (Co.Th)
Dapagliflozin → Cortical thickness (Co.Th)
Dapagliflozin → Intra-cortical porosity (Ct.Po)
Dapagliflozin → Intra-cortical porosity (Ct.Po)
Dapagliflozin → Trabecular thickness (Tb.Th)
Dapagliflozin → Trabecular thickness (Tb.Th)
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on SGLT2 Inhibitors and Bone Mineral Density, SGLT2 Inhibitors and Bone Mineral Density.
This study contributes to the evidence on the following intervention-outcome relationships.
Medications
Medications
Curated evidence collections and hubs this study is part of.
All studies measuring Bone Mineral Density
Measures Bone Mineral Density as a key outcome.
All studies on SGLT2 Inhibitors
Contributes to SGLT2 Inhibitors evidence base.
Latest published studies
Published within the last 2 years.
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1 results
1 results
1 results
1 results
1 results
Generated from the study's connected evidence using Evidence Intelligence™.
SGLT2 Inhibitors may improve Kidney Function.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
Serum CTX-1
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on 10 supporting studies with consistent results and a positive effect signal.
Limitations
Current evidence does not show a clear benefit of SGLT2 Inhibitors for Bone Mineral Density.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Bone mineral density (BMD)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Bone mineral density (BMD) at distal radius
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Bone mineral density (BMD) at femoral neck
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Dapagliflozin appears to improve Cortical pore diameter (Ct.Po.Dm) at radius.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Cortical pore diameter (Ct.Po.Dm) at radius
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Dapagliflozin appears to improve Cortical pore diameter (Ct.Po.Dm) at tibia.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Cortical pore diameter (Ct.Po.Dm) at tibia
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | strong positive | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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