Last updated September 9, 2026
Key finding
Symptomatic women had a higher level of anxiety based on the STAI-6 questionnaire (14.5 ± 3.6 vs. 11.2 ± 2.6, p < 0.001).
This study examined the relationship between depressive symptoms and metabolic profiles in women with prior gestational diabetes mellitus, finding significant associations with anxiety and metabolic syndrome.
Quick read
The essential study design details in one scan.
EvidenceScore™
Moderate
Study type
RCTs
Follow-up
Short-Term (≤3 mo)
Risk of bias
Some Concerns
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Plain-language summary
A plain-language read of the study’s main message and where it applies.
Study focus
This study examined the relationship between depressive symptoms and metabolic profiles in women with prior gestational diabetes mellitus, finding significant associations with anxiety and metabolic syndrome.
Understanding the link between depressive symptoms and metabolic health is crucial for clinicians working with women who have had gestational diabetes. Addressing mental health may improve overall health outcomes, as these women are at higher risk for both psychological and metabolic disorders.
The study may not be generalizable due to a specific population focus. Effectiveness of the interventions was unclear based on the results. Potential confounding factors were not fully explored.
Published in
Publication details and source links for this paper.
Yana V, Caro M, Karolijn VDK, et al. Association between Depressive Symptoms and Metabolic Profile in Women with Prior Gestational Diabetes Mellitus. Journal of Clinical Medicine. 2025;14(10):3592. doi:10.3390/jcm14103592
Women with depressive symptoms had a higher prevalence of metabolic syndrome (38.6% vs. 21.9%, p = 0.044).
Symptomatic women exhibited higher LDL-cholesterol levels (3.2 ± 0.8 vs. 2.8 ± 0.8 mmol/L, p = 0.009).
Women with depressive symptoms reported higher anxiety levels (14.5 ± 3.6 vs. 11.2 ± 2.6, p < 0.001).
Evidence network
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This study contributes evidence to Lifestyle intervention for prediabetes and Anxiety level (STAI-6 scores), Depressive symptoms prevalence, LDL cholesterol, and 2 more.
This study contributes evidence to
Primary intervention
Lifestyle intervention for prediabetes
Primary outcomes
Evidence topics
Primary intervention
Intervention and outcome relationships this study adds to the evidence network.
Editorial context
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Evidence network role
This section describes how the study fits into the current evidence network. It does not determine whether an intervention works on its own.
1
Related topics
5
Evidence pairs
123
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Evidence topic
Contributes evidence
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Primary evidence
Evidence topic
matched_outcome
Core evidence
The primary outcomes reported in this study.
Lifestyle intervention for prediabetes → Anxiety level (STAI-6 scores)
Lifestyle intervention for prediabetes → Anxiety level (STAI-6 scores)
Lifestyle intervention for prediabetes → Depressive symptoms prevalence
Lifestyle intervention for prediabetes → Depressive symptoms prevalence
Lifestyle intervention for prediabetes → LDL cholesterol
Lifestyle intervention for prediabetes → LDL cholesterol
Lifestyle intervention for prediabetes → Postoperative Sleep Conditions Monitored by Sleep Bracelets
Lifestyle intervention for prediabetes → Postoperative Sleep Conditions Monitored by Sleep Bracelets
Lifestyle intervention for prediabetes → Quality of life
Lifestyle intervention for prediabetes → Quality of life
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Relationships organized using the Dediabetes Evidence Intelligence™ framework.
This study contributes to evidence on Lifestyle intervention for prediabetes and Quality of Life Outcomes, Lifestyle intervention for prediabetes and Adipokine and Angiogenic Markers.
This study contributes to the evidence on the following intervention-outcome relationships.
Behavioral & Lifestyle
Behavioral & Lifestyle
Behavioral & Lifestyle
Curated evidence collections and hubs this study is part of.
All studies on Lifestyle intervention for prediabetes
Contributes to Lifestyle intervention for prediabetes evidence base.
All studies measuring Quality of Life Outcomes
Measures Quality of Life Outcomes as a key outcome.
All studies measuring Adipokine and Angiogenic Markers
Measures Adipokine and Angiogenic Markers as a key outcome.
All studies measuring Anxiety level (STAI-6 scores)
Measures Anxiety level (STAI-6 scores) as a key outcome.
Latest published studies
Published within the last 2 years.
Jump to pre-filtered views in Evidence Explorer.
3 results
2 results
3 results
3 results
2 results
Generated from the study's connected evidence using Evidence Intelligence™.
Lifestyle intervention for prediabetes may improve quality of life.
ConsistencyScore™: Results are generally consistent across studies.
Ranked evidence signals
Quality of life
EvidenceScore™ Strong | EvidenceScore™ 75.4 | weak positive | ConsistencyScore™ Generally Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lifestyle intervention for prediabetes for ldl cholesterol.
ConsistencyScore™: Results are consistent across studies.
Ranked evidence signals
LDL cholesterol
EvidenceScore™ Moderate | EvidenceScore™ 69.0 | neutral | ConsistencyScore™ Consistent | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lifestyle intervention for prediabetes for anxiety level (stai-6 scores).
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Anxiety level (STAI-6 scores)
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
Current evidence does not show a clear benefit of Lifestyle intervention for prediabetes for depressive symptoms prevalence.
ConsistencyScore™: Consistency cannot yet be determined from the available evidence.
Ranked evidence signals
Depressive symptoms prevalence
EvidenceScore™ Emerging | EvidenceScore™ 59.0 | neutral | ConsistencyScore™ Unclear | 1 study
Why this answer: This answer is based on a single supporting study.
Limitations
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